1-benzyl-3-(hydroxyMethyl)piperidin-4-ol synthesis
- Product Name:1-benzyl-3-(hydroxyMethyl)piperidin-4-ol
- CAS Number:886-46-4
- Molecular formula:C13H19NO2
- Molecular Weight:221.3
1454-53-1
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Yield:886-46-4 61%
Reaction Conditions:
Stage #1: ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloridewith sodium hydroxide;water in methanol at 20;
Stage #2: with sodium tetrahydroborate in methanol at 0 - 20;
Steps:
A.9.1
The title compound was prepared as provided in Synthesis 1999,1937- 1943.
References:
WO2005/26145,2005,A2 Location in patent:Page/Page column 84; 107
41276-30-6
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956010-25-6
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