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109859-99-6

1-Benzyl-2-oxopyrrolidine-3-carboxylic acid synthesis

5synthesis methods
3-Pyrrolidinecarboxylic acid, 2-oxo-1-(phenylmethyl)-, methyl ester

71725-74-1
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1-Benzyl-2-oxopyrrolidine-3-carboxylic acid

109859-99-6
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Yield:109859-99-6 100%

Reaction Conditions:

Stage #1: methyl 1-benzyl-2-oxo-pyrrolidine-3-carboxylatewith water;sodium hydroxide in methanol;
Stage #2: with hydrogenchloride in water;

References:

Adediran;Cabaret;Lohier;Wakselman;Pratt [Bioorganic and Medicinal Chemistry,2010,vol. 18,# 1,p. 282 - 291] Location in patent:experimental part