1-(6-CHLORO-PYRIDIN-2-YL)-PIPERAZINE synthesis
- Product Name:1-(6-CHLORO-PYRIDIN-2-YL)-PIPERAZINE
- CAS Number:87394-54-5
- Molecular formula:C9H12ClN3
- Molecular Weight:197.66
110-85-0
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2402-78-0
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584-08-7
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87394-54-5
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Yield:87394-54-5 90%
Reaction Conditions:
in water;acetonitrile;
Steps:
4 1-(6-Chloro-2-pyridinyl)piperazine
EXAMPLE 4 1-(6-Chloro-2-pyridinyl)piperazine A mixture of 2.6-dichloropyridine (4.0 g), anhydrous piperazine (6.97 g), and micropulverized anhydrous K2 CO3 (7.45 g) in acetonitrile (50 ml) was heated at reflux with stirring while under N2 atmosphere for 20 h. The excess acetonitrile was removed under reduced pressure and water (15 mL) added to the concentrate. The aqueous phase was extracted with CH2 Cl2 (3*50 mL). The combined CH2 Cl2 extracts were washed with sat. NaCl solution, dried with anhydrous MgSO4, are concentrated under reduced pressure. Silica gel chromatc,graphy (CH2 Cl2 /MeOH/NH4 OH; 94:6:0.6) of the residue yielded 1-(6-chloro-2-pyridinyl)piperazine (4.80 g; 90%).
References:
US4954502,1990,A
854159-19-6
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87394-54-5
49 suppliers
$60.00/50mg
110-85-0
583 suppliers
$5.00/5G
2402-78-0
522 suppliers
$6.00/25g
87394-54-5
49 suppliers
$60.00/50mg
2402-78-0
522 suppliers
$6.00/25g
120-43-4
287 suppliers
$6.00/5g
87394-54-5
49 suppliers
$60.00/50mg
854159-11-8
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87394-54-5
49 suppliers
$60.00/50mg