ChemicalBook CAS DataBase List 1-(5-CHLORO-PYRIDIN-2-YL)-PIPERAZINE

1-(5-CHLORO-PYRIDIN-2-YL)-PIPERAZINE synthesis

5synthesis methods

Product Name:1-(5-CHLORO-PYRIDIN-2-YL)-PIPERAZINE
CAS Number:87394-65-8
Molecular formula:C9H12ClN3
Molecular Weight:197.66

TERT-BUTYL 4-(5-CHLOROPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE

945422-86-6
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$904.00/5g

87394-65-8
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$21.00/250mg

Yield:87394-65-8 99%

Reaction Conditions:

Stage #1: tert-butyl 4-(5-chloropyridin-2-yl)piperazine-1-carboxylatewith trifluoroacetic acid in MC at 20; for 2 h;
Stage #2: with sodium hydrogencarbonate in water;

Steps:

85.2

Step 2: Synthesis of 1-(5-Chloropyridin-2-yl)piperazine [255] Tert-butyl 4-(5-chloropyridin-2-yl)piperazine-1-carboxylate (170 mg, 0.571 mmol) was dissolved in MC (3 ml), followed by addition of trifluoroacetic acid (3 ml), and then the resulting mixture was stirred at room temperature for 2 hours. The resulting reaction liquid was concentrated under reduced pressure, followed by addition of a saturated aqueous NaHCO₃ solution (15 ml), and extracted with MC (15 ml x 3). The organic layer was dried over anhydrous sodium sulfate, followed by filtration, concentration, and vacuum drying, to obtain 112 mg of white solid (99%).

References:

WO2011/139107,2011,A2 Location in patent:Page/Page column 39

110-85-0 Synthesis