ChemicalBook CAS DataBase List 1-(5-CHLORO-2-NITROPHENYL)-1-ETHANONE

1-(5-CHLORO-2-NITROPHENYL)-1-ETHANONE synthesis

6synthesis methods

Product Name:1-(5-CHLORO-2-NITROPHENYL)-1-ETHANONE
CAS Number:18640-60-3
Molecular formula:C8H6ClNO3
Molecular Weight:199.59

99-02-5 Synthesis

99-02-5
294 suppliers
$9.00/1g

18640-60-3
94 suppliers
inquiry

Yield: 85%

Reaction Conditions:

with sulfuric acid;nitric acid at -18;

Steps:

2.1 Synthesis of 2-nitro-5-chloroacetophenone
100 g of m-chloroacetophenone was slowly added dropwise to 500 ml of sulfuric acid nitric acid mixture (volume ratio 1: 6.5, minus 18 degrees), and the temperature was stirred overnight. Was added to ice water and filtered to give 110 g of 2-nitro-5-chloroacetophenone as a yellow solid in 85% yield.

References:

shanghai Bide pharmatech co. ltd;Wang, Chao;Li, Ronghao;Huang, Dongrui;Liu, Han CN102898374, 2016, B Location in patent:Paragraph 0035-0038

99-02-5 Synthesis

99-02-5
294 suppliers
$9.00/1g

18640-60-3
94 suppliers
inquiry