ChemicalBook CAS DataBase List 1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE

1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE synthesis

3synthesis methods

Product Name:1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE
CAS Number:780753-89-1
Molecular formula:C10H11FN2O
Molecular Weight:194.21

1284243-44-2 Synthesis

tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate

1284243-44-2
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780753-89-1
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$251.00/250mg

Yield:780753-89-1 77%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane;dichloromethane at 0 - 25; for 3 h;

Steps:

3.2 Step 2: 1 -(4-fluorophenyl) piperazin-2-one.

To the solution of tert-butyl 4-(4-fluorophenyl)-3-oxopiperazine- 1-carboxylate (2g, 6.80 mmol) in dichloromethane (5 ml) was added slowly hydrogenchloride in1,4-dioxane (16.99 ml, 68.0 mmol) at 0°C and reaction was stirred for 3 h at 25°C. After completion of the reaction, the solvent was evaporated under reduced pressure to obtained salt was triturated with diethyl ether (2 x 10 ml) decanted it and dried to give 1-(4-fluorophenyl)piperazin-2-one hydrochloride (1.2 g, 5.20mmol, 77 %)‘H NMR (400 MHz, DMSO-d6) 6 9.90 (bs, 1H, D20 exchangeable), 7.38-7.34 (m, 4H), 3.85-3.72 (m, 4H), 3. 55-3.50 (m, 2H).MS: m/z 195 (M+1).

References:

WO2014/9872,2014,A1 Location in patent:Page/Page column 64

5625-67-2 Synthesis