ChemicalBook CAS DataBase List 1-(4-FLUORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE

1-(4-FLUORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE synthesis

6synthesis methods

Product Name:1-(4-FLUORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE
CAS Number:192997-23-2
Molecular formula:C16H12FNO
Molecular Weight:253.27

487-89-8 Synthesis

487-89-8
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1-(4-FLUORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE

192997-23-2
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$95.00/500mg

Yield:192997-23-2 86%

Reaction Conditions:

Stage #1: Indole-3-carboxaldehydewith sodium hydride at 0;
Stage #2: with water for 2 h;Cooling with ice;

Steps:

General procedure for preparation of N-benzyl indole aldehydes

General procedure: In a typical experimental procedure, indole aldehyde (1 mmol) and sodium hydride (3 mmol) were stirred at zero degree for 15 min; to it corresponding benzyl halide (1.5 mmol) was added, and the reaction mixture was stirred for 5-6 h. After completion of the reaction (monitored using TLC), the mixture was cooled, poured in crushed ice, 200 ml water was added and stirred for 2 h to separate out product, and filtered product was washed and recrystallized by petroleum ether.

References:

Survase, Dattatray N.;Karhale, Shrikrishna S.;Khedkar, Vijay M.;Helavi, Vasant B. [Synthetic Communications,2019,vol. 49,# 24,p. 3486 - 3497] Location in patent:supporting information

487-89-8 Synthesis

487-89-8
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$6.00/10g

352-11-4 Synthesis