ChemicalBook CAS DataBase List 1,4-DINITROBENZENE

1,4-DINITROBENZENE synthesis

13synthesis methods

Product Name:1,4-DINITROBENZENE
CAS Number:100-25-4
Molecular formula:C6H4N2O4
Molecular Weight:168.11

106-50-3 Synthesis

106-50-3
609 suppliers
$19.00/25g

100-25-4
6 suppliers
$46.00/5g

Yield:100-25-4 77%

Reaction Conditions:

with trifluoroacetyl peroxide in dichloromethane at -5 - 5; for 1 h;

Steps:

2
Add a peroxytrifluoroacetic acid solution to the reaction vessel, lower the temperature to -5 to 5 ° C, add 381.7g (3.53mol) of p-aminoaniline, keep the temperature at -5 to 5 ° C, and stir the reaction for 1 hour. After the reaction, add 2L of water and stir , The layers were left to stand, and the organic layer was washed with 2L saturated sodium bisulfite solution, 2L saturated sodium bicarbonate solution, and water to pH 7-8, and the solvent was distilled off under reduced pressure. Dichloromethane and methanol (dichloromethane and The volume ratio of methanol was 1: 2) The solution was recrystallized to obtain 456.9 g (yield 77%) of the product as a yellow solid p-nitronitrobenzene

References:

Chongqing Pharmaceutical College;Liu Dianqing;He Dongxian;Wang Kun;Guo Shengchao;Wang Guangming CN110330432, 2019, A Location in patent:Paragraph 0025; 0029

FullText