1,3-Dibromo-2,2-dimethoxypropane synthesis
- Product Name:1,3-Dibromo-2,2-dimethoxypropane
- CAS Number:22094-18-4
- Molecular formula:C5H10Br2O2
- Molecular Weight:261.94
Yield:22094-18-4 60%
Reaction Conditions:
with bromine at 0 - 20; for 15 h;
Steps:
29 1,3-dibromo-2,2-dimethoxypropane (29.2)
To a stirring solutionof compound 29.1(157g, 2.7 mol) in CH30H (1.6 L) at 0°Cwas added Br2 (950 g, 5.9 moL) dropwise, and the reactionwas stirred with warming tort for 15 hr. The precipitate was collected by filtration and was washed with cold methanol to yield5 compound29.2 (450 g, 60%) as a white solid.
References:
ACHAOGEN, INC.;LINSELL, Martin Sheringham;AGGEN, James Bradley;DOZZO, Paola;HILDEBRANDT, Darin James;COHEN, Frederick;KASAR, Ramesh Annasaheb;KANE, Timothy Robert;GLIEDT, Micah James;MCENROE, Glenn A. WO2014/165075, 2014, A1 Location in patent:Page/Page column 86; 87
67-56-1
757 suppliers
$7.29/5ml-f
816-39-7
143 suppliers
$75.00/250 mg
22094-18-4
322 suppliers
$5.00/1g
67-56-1
757 suppliers
$7.29/5ml-f
77-76-9
397 suppliers
$9.00/5ml
22094-18-4
322 suppliers
$5.00/1g
126-38-5
133 suppliers
$12.00/1g