lifitegrast
|
- $32 - $1400
- Product name: lifitegrast
- CAS: 1025967-78-5
- MF: C29H24Cl2N2O7S
- MW: 615.48
- EINECS:813-044-8
- MDL Number:MFCD28502439
- Synonyms:lifitegrast;Lifitegrast, SAR 1118;L-Phenylalanine,N-[[2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-;N-[[2-(6-Benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-L-phenylalanine;SAR 1118;(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic;Lifitegrast（API）;SAR-1118;SAR1118
27 prices
Selected condition：
Brand
- Activate Scientific
- AK Scientific
- Alichem
- Biosynth Carbosynth
- Cayman Chemical
- Chemcia Scientific
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 2.5mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 0.25G
- 1g
- ManufacturerActivate Scientific
- Product numberAS59476
- Product descriptionLifitegrast 95+%
- Packaging1mg
- Price$59
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS59476
- Product descriptionLifitegrast 95+%
- Packaging5mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS59476
- Product descriptionLifitegrast 95+%
- Packaging25mg
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS59476
- Product descriptionLifitegrast 95+%
- Packaging100mg
- Price$216
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS59476
- Product descriptionLifitegrast 95+%
- Packaging250mg
- Price$437
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number1840CT
- Product descriptionLifitegrast
- Packaging10mg
- Price$164
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number1025967785
- Product description(S)-2-(2-(Benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoicacid
- Packaging250mg
- Price$521.36
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number1025967785
- Product description(S)-2-(2-(Benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoicacid
- Packaging1g
- Price$1396.5
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB146398
- Product descriptionLifitegrast
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB146398
- Product descriptionLifitegrast
- Packaging50mg
- Price$275
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22588
- Product descriptionLifitegrast ≥98%
- Packaging5mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22588
- Product descriptionLifitegrast ≥98%
- Packaging10mg
- Price$61
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22588
- Product descriptionLifitegrast ≥98%
- Packaging25mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22588
- Product descriptionLifitegrast ≥98%
- Packaging50mg
- Price$243
- Updated2024-03-01
- Buy
- ManufacturerChemcia Scientific
- Product numberCC00-8804
- Product descriptionLIFITEGRAST ＞95%
- Packaging0.25G
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM144186
- Product description(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoicacid 97%
- Packaging1g
- Price$514
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Activate Scientific | AS59476 | Lifitegrast 95+% | 1mg | $59 | 2021-12-16 | Buy |
| Activate Scientific | AS59476 | Lifitegrast 95+% | 5mg | $105 | 2021-12-16 | Buy |
| Activate Scientific | AS59476 | Lifitegrast 95+% | 25mg | $189 | 2021-12-16 | Buy |
| Activate Scientific | AS59476 | Lifitegrast 95+% | 100mg | $216 | 2021-12-16 | Buy |
| Activate Scientific | AS59476 | Lifitegrast 95+% | 250mg | $437 | 2021-12-16 | Buy |
| AK Scientific | 1840CT | Lifitegrast | 10mg | $164 | 2021-12-16 | Buy |
| Alichem | 1025967785 | (S)-2-(2-(Benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoicacid | 250mg | $521.36 | 2021-12-16 | Buy |
| Alichem | 1025967785 | (S)-2-(2-(Benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoicacid | 1g | $1396.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB146398 | Lifitegrast | 10mg | $125 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB146398 | Lifitegrast | 50mg | $275 | 2021-12-16 | Buy |
| Cayman Chemical | 22588 | Lifitegrast ≥98% | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 22588 | Lifitegrast ≥98% | 10mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 22588 | Lifitegrast ≥98% | 25mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 22588 | Lifitegrast ≥98% | 50mg | $243 | 2024-03-01 | Buy |
| Chemcia Scientific | CC00-8804 | LIFITEGRAST ＞95% | 0.25G | $350 | 2021-12-16 | Buy |
| Chemenu | CM144186 | (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoicacid 97% | 1g | $514 | 2021-12-16 | Buy |
Properties
Melting point :>163°C (dec.)
Boiling point :811.9±65.0 °C(Predicted)
Density :1.479±0.06 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Sonicated)
form :Solid
pka :3.14±0.10(Predicted)
color :White to Off-White
Stability :Hygroscopic
InChIKey :JFOZKMSJYSPYLN-QHCPKHFHSA-N
SMILES :C(O)(=O)[C@H](CC1=CC=CC(S(C)(=O)=O)=C1)NC(C1C(Cl)=CC2=C(C=1Cl)CCN(C(C1C=C3OC=CC3=CC=1)=O)C2)=O
Boiling point :811.9±65.0 °C(Predicted)
Density :1.479±0.06 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Sonicated)
form :Solid
pka :3.14±0.10(Predicted)
color :White to Off-White
Stability :Hygroscopic
InChIKey :JFOZKMSJYSPYLN-QHCPKHFHSA-N
SMILES :C(O)(=O)[C@H](CC1=CC=CC(S(C)(=O)=O)=C1)NC(C1C(Cl)=CC2=C(C=1Cl)CCN(C(C1C=C3OC=CC3=CC=1)=O)C2)=O
Safety Information
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Description
Lifitegrast (Xiidra; lifitegrast sodium; SAR1118; SHP606; SPD606) is a lymphocyte functionassociated antigen-1 (LFA-1) antagonist. It inhibits T-cell inflammation by blocking the binding of two key surface proteins (LFA-1 and ICAM-1) that mediate the chronic inflammatory cascade associated with dry eye disease. In a phase III clinical trial, lifitegrast 5% ophthalmic solution (50 mg/mL) is administered as a single 0.2mL eye drop twice a day into each eye for an 84 day treatment period.
Lifitegrast does not currently have Marketing Authorisation in the EU for any indication. Lifitegrast is licensed for use in the USA for treatment of the signs and symptoms of dry eye disease. The most common adverse reactions (incidence 5-25%) reported following the use of lifitegrast are instillation site irritation, dysgeusia, and decreased visual acuity.
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Suppliers and manufacturers
PharmOrgSyn Laboratories Co., Ltd.
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ATK CHEMICAL COMPANY LIMITED
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