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ChemicalBook >> CAS DataBase List >> Zoledronic acid hydrate

Zoledronic acid hydrate

Zoledronic acid hydrate price.
  • $6 - $486
  • Product name: Zoledronic acid hydrate
  • CAS: 165800-06-6
  • MF: C5H12N2O8P2
  • MW: 290.1
  • EINECS:
  • MDL Number:MFCD08448695
  • Synonyms:[1-HYDROXY-(1H-IMIDAZOL-1-YL)-PHOSPHONOETHYL] PHOSPHONIC ACID MONOHYDRATE;(1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl)phosphonic acid hydrate;(1-hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid monohydrate;PHOSPHONIC ACID, [1-HYDROXY-2-(1H-IMIDAZOL-1-YL)ETHYLIDENE]BIS-, MONOHYDRATE;zoledronic acid hydrate;ZoledronicacidforInjection;[1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate;P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate
37 prices
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  • Abosyn
  • AHH
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • Arctom
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Chem-Impex
  • Crysdot
  • CSNpharm
  • DC Chemicals
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Package
  • 10MG
  • 25mg
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  • 0.1g
  • 150mg
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  • 1g
  • 5g
  • 25g
  • ManufacturerAbosyn
  • Product number61-10991
  • Product description(1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonicacidhydrate 95-98%
  • Packaging1g
  • Price$54
  • Updated2021-12-16
  • Buy
  • ManufacturerAbosyn
  • Product number61-10991
  • Product description(1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonicacidhydrate 95-98%
  • Packaging5g
  • Price$486
  • Updated2021-12-16
  • Buy
  • ManufacturerAHH
  • Product numberMT-21417
  • Product descriptionPhosphonicacid,[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-,monohydrate 98%
  • Packaging0.1g
  • Price$475
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH683
  • Product descriptionZoledronic Acid Monohydrate
  • Packaging5g
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA211103
  • Product description(1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonicacidhydrate 98%
  • Packaging50mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA211103
  • Product description(1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonicacidhydrate 98%
  • Packaging100mg
  • Price$11
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA211103
  • Product description(1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonicacidhydrate 98%
  • Packaging250mg
  • Price$16
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA211103
  • Product description(1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonicacidhydrate 98%
  • Packaging1g
  • Price$41
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA211103
  • Product description(1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonicacidhydrate 98%
  • Packaging5g
  • Price$109
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0015608
  • Product descriptionZOLEDRONIC ACID MONOHYDRATE 95.00%
  • Packaging10MG
  • Price$139.65
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS025691
  • Product descriptionZoledronic Acid Monohydrate 98%
  • Packaging50mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS025691
  • Product descriptionZoledronic Acid Monohydrate 98%
  • Packaging100mg
  • Price$11
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS025691
  • Product descriptionZoledronic Acid Monohydrate 98%
  • Packaging250mg
  • Price$16
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS025691
  • Product descriptionZoledronic Acid Monohydrate 98%
  • Packaging1g
  • Price$41
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS025691
  • Product descriptionZoledronic Acid Monohydrate 98%
  • Packaging5g
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number1715H
  • Product descriptionZoledronic Acid Hydrate
  • Packaging100mg
  • Price$39
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Abosyn 61-10991 (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonicacidhydrate 95-98% 1g $54 2021-12-16 Buy
Abosyn 61-10991 (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonicacidhydrate 95-98% 5g $486 2021-12-16 Buy
AHH MT-21417 Phosphonicacid,[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-,monohydrate 98% 0.1g $475 2021-12-16 Buy
AK Scientific H683 Zoledronic Acid Monohydrate 5g $300 2021-12-16 Buy
Ambeed A211103 (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonicacidhydrate 98% 50mg $6 2021-12-16 Buy
Ambeed A211103 (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonicacidhydrate 98% 100mg $11 2021-12-16 Buy
Ambeed A211103 (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonicacidhydrate 98% 250mg $16 2021-12-16 Buy
Ambeed A211103 (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonicacidhydrate 98% 1g $41 2021-12-16 Buy
Ambeed A211103 (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonicacidhydrate 98% 5g $109 2021-12-16 Buy
American Custom Chemicals Corporation API0015608 ZOLEDRONIC ACID MONOHYDRATE 95.00% 10MG $139.65 2021-12-16 Buy
Arctom AS025691 Zoledronic Acid Monohydrate 98% 50mg $6 2021-12-16 Buy
Arctom AS025691 Zoledronic Acid Monohydrate 98% 100mg $11 2021-12-16 Buy
Arctom AS025691 Zoledronic Acid Monohydrate 98% 250mg $16 2021-12-16 Buy
Arctom AS025691 Zoledronic Acid Monohydrate 98% 1g $41 2021-12-16 Buy
Arctom AS025691 Zoledronic Acid Monohydrate 98% 5g $108 2021-12-16 Buy
AvaChem 1715H Zoledronic Acid Hydrate 100mg $39 2021-12-16 Buy

Properties

Melting point :245 °C(dec.)
storage temp. :2-8°C
solubility :H2O: ≥2mg/mL
form :powder
color :white to beige
Merck :14,10187
InChIKey :FUXFIVRTGHOMSO-UHFFFAOYSA-N
CAS DataBase Reference :165800-06-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Zoledronic acid is a third-generation heterocyclic nitrogen-containing bisphosphonate that inhibits the prenylation of GTPases critical to the signaling events related to osteoclast-mediated bone resorption. It has a high affinity for hydroxyapatite (Ki = 3.47 μM) and binds directly to mineralized bone where it decreases bone resorption by inhibiting osteoclast proliferation and inducing osteoclast apoptosis. At μM concentrations, zoledronic acid demonstrates antitumor effects in vitro against breast, prostate, and myeloma cancer cells by inducing cytostasis and prevents bone metastases through its inhibitory effects on adhesion molecules, tumor cell invasion, and angiogenesis. Zoledronic acid has been used in the treatment of osteoporosis, Paget’s disease, metastatic bone disease, multiple myeloma, hypercalcemia of malignancy, and skeletal-related events associated with metastatic castrate-resistant prostate cancer.

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