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ChemicalBook >> CAS DataBase List >> WYE-354

WYE-354

WYE-354 price.
  • $36 - $1963.5
  • Product name: WYE-354
  • CAS: 1062169-56-5
  • MF: C24H29N7O5
  • MW: 495.53
  • EINECS:-0
  • MDL Number:MFCD18074514
  • Synonyms:WYE-354;4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid methyl ester;methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate;WYE-354 (Degrasyn);WYE-354;WYE 354; WYE354;Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pip;CS-441;1-Piperidinecarboxylic acid, 4-[6-[4-[(methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, methyl ester
38 prices
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Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberX7422
  • Product descriptionmethyl-4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
  • Packaging250mg
  • Price$1091
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA121661
  • Product descriptionWye-354 98+%
  • Packaging5mg
  • Price$36
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA121661
  • Product descriptionWye-354 98+%
  • Packaging10mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA121661
  • Product descriptionWye-354 98+%
  • Packaging25mg
  • Price$136
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA121661
  • Product descriptionWye-354 98+%
  • Packaging50mg
  • Price$220
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA121661
  • Product descriptionWye-354 98+%
  • Packaging100mg
  • Price$369
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA121661
  • Product descriptionWye-354 98+%
  • Packaging250mg
  • Price$764
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000840
  • Product descriptionWYE-354 95.00%
  • Packaging5MG
  • Price$545
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000840
  • Product descriptionWYE-354 95.00%
  • Packaging10MG
  • Price$750.75
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000840
  • Product descriptionWYE-354 95.00%
  • Packaging100MG
  • Price$1963.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1266
  • Product descriptionWYE-354
  • Packaging5mg
  • Price$104
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1266
  • Product descriptionWYE-354
  • Packaging10mg
  • Price$198
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1266
  • Product descriptionWYE-354
  • Packaging25mg
  • Price$469
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1266
  • Product descriptionWYE-354
  • Packaging50mg
  • Price$832
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60432
  • Product descriptionWYE-354 ≥98%
  • Packaging10mg
  • Price$238
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13604
  • Product descriptionWYE-354 ≥98%
  • Packaging5mg
  • Price$93
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7422 methyl-4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate 250mg $1091 2021-12-16 Buy
Ambeed A121661 Wye-354 98+% 5mg $36 2021-12-16 Buy
Ambeed A121661 Wye-354 98+% 10mg $65 2021-12-16 Buy
Ambeed A121661 Wye-354 98+% 25mg $136 2021-12-16 Buy
Ambeed A121661 Wye-354 98+% 50mg $220 2021-12-16 Buy
Ambeed A121661 Wye-354 98+% 100mg $369 2021-12-16 Buy
Ambeed A121661 Wye-354 98+% 250mg $764 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000840 WYE-354 95.00% 5MG $545 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000840 WYE-354 95.00% 10MG $750.75 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000840 WYE-354 95.00% 100MG $1963.5 2021-12-16 Buy
ApexBio Technology A1266 WYE-354 5mg $104 2021-12-16 Buy
ApexBio Technology A1266 WYE-354 10mg $198 2021-12-16 Buy
ApexBio Technology A1266 WYE-354 25mg $469 2021-12-16 Buy
ApexBio Technology A1266 WYE-354 50mg $832 2021-12-16 Buy
Arctom CFN60432 WYE-354 ≥98% 10mg $238 2021-12-16 Buy
Cayman Chemical 13604 WYE-354 ≥98% 5mg $93 2024-03-01 Buy

Properties

Density :1.46
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :≥49.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :13.42±0.70(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of phosphatidylinositol 3-kinase α (IC50 = 1026 nM) and other kinases. WYE-354 induces G1 cell cycle arrest in both rapamycin-sensitive and rapamycin-resistant cancer cell lines, inhibits mTORC1 and mTORC2 in tumor-bearing mice, and reduces tumor growth in nude mice with PTEN-null tumors.

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