UMI-77
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- $32 - $1125
- Product name: UMI-77
- CAS: 518303-20-3
- MF: C18H14BrNO5S2
- MW: 468.34
- EINECS:
- MDL Number:MFCD03471890
- Synonyms:2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid;UMI-77;2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid;2-[4-[(4-Bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid UMI-77;Acetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-;UMI 77;UMI77;CS-1799;UMI-77 USP/EP/BP
13 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 100mg
- 10mM(in 1mL DMSO)
- 50mg
- ManufacturerAK Scientific
- Product number2780AH
- Product description2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)aceticacid
- Packaging50mg
- Price$517
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004698
- Product descriptionUMI-77 95.00%
- Packaging5MG
- Price$500.67
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4881
- Product descriptionUMI-77
- Packaging5mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4881
- Product descriptionUMI-77
- Packaging10mM(in 1mL DMSO)
- Price$115
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4881
- Product descriptionUMI-77
- Packaging25mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19148
- Product descriptionUMI-77 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19148
- Product descriptionUMI-77 ≥98%
- Packaging5mg
- Price$93
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19148
- Product descriptionUMI-77 ≥98%
- Packaging10mg
- Price$169
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD31001659
- Product descriptionUMI-77 98+%
- Packaging50mg
- Price$513
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7950
- Product descriptionUMI-77 >98%
- Packaging100mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number62524
- Product descriptionUMI-77
- Packaging25mg
- Price$1125
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberU700850
- Product descriptionUMI-77
- Packaging1mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number468454
- Product descriptionUMI-77
- Packaging1mg
- Price$382
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2780AH | 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)aceticacid | 50mg | $517 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004698 | UMI-77 95.00% | 5MG | $500.67 | 2021-12-16 | Buy |
| ApexBio Technology | B4881 | UMI-77 | 5mg | $100 | 2021-12-16 | Buy |
| ApexBio Technology | B4881 | UMI-77 | 10mM(in 1mL DMSO) | $115 | 2021-12-16 | Buy |
| ApexBio Technology | B4881 | UMI-77 | 25mg | $360 | 2021-12-16 | Buy |
| Cayman Chemical | 19148 | UMI-77 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19148 | UMI-77 ≥98% | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 19148 | UMI-77 ≥98% | 10mg | $169 | 2024-03-01 | Buy |
| Crysdot | CD31001659 | UMI-77 98+% | 50mg | $513 | 2021-12-16 | Buy |
| DC Chemicals | DC7950 | UMI-77 >98% | 100mg | $450 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 62524 | UMI-77 | 25mg | $1125 | 2021-12-16 | Buy |
| TRC | U700850 | UMI-77 | 1mg | $100 | 2021-12-16 | Buy |
| Usbiological | 468454 | UMI-77 | 1mg | $382 | 2021-12-16 | Buy |
Properties
Boiling point :661.2±65.0 °C(Predicted)
Density :1.79±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23.4 mg/mL in DMSO; insoluble in H2O; ≥7.2 mg/mL in EtOH
form :solid
pka :2.41±0.30(Predicted)
color :White to off-white
Density :1.79±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23.4 mg/mL in DMSO; insoluble in H2O; ≥7.2 mg/mL in EtOH
form :solid
pka :2.41±0.30(Predicted)
color :White to off-white
Safety Information
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Description
Myeloid cell leukemia-1 (Mcl-1) is a potent anti-apoptotic protein and a member of the pro-survival Bcl-2 family. UMI-77 is a selective Mcl-1 inhibitor with a Ki value of 490 nM and exhibits selectivity over other members of the Bcl-2 family (Kis = 5.3, 23.8, 33.0, and 8.2 μM) for A1/Bfl-1, Bcl-2, Bcl-xL, and Bcl-W, respectively). It has been shown to disrupt the heterodimerization of Mcl-1/Bax and Mcl-1/Bak, thus antagonizing Mcl-1 function. UMI-77 inhibits the growth of various pancreatic cancer cell lines with IC50s values ranging from 3.4-16.1 μM, inducing apoptosis through activation of the intrinsic apoptotic pathway and/or Bax conformational change. In a BxPC-3 xenograft mouse model, 60 mg/kg UMI-77 demonstrated antitumor activity without damaging normal tissues.Related product price
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Suppliers and manufacturers
career henan chemical co
![Acetic acid, 2-?[[4-?[[(4-?bromophenyl)?sulfonyl]?amino]?-?1-?hydroxy-?2-?naphthalenyl]?thio]?-](https://img.chemicalbook.com/ProductImageEN/2020-1/small/f2f66fd1-6cd5-49ae-b920-b37f4c89c17a.png)
Nanjing ChemLin Chemical Industry Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Dideu Industries Group Limited
Shenzhen Shengda Pharma Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Hangzhou MolCore BioPharmatech Co.,Ltd.
TargetMol Chemicals Inc.
$1.00 /1KG
Acetic acid, 2-?[[4-?[[(4-?bromophenyl)?sulfonyl]?amino]?-?1-?hydroxy-?2-?naphthalenyl]?thio]?- CAS:518303-20-3
Acetic acid, 2-?[[4-?[[(4-?bromophenyl)?sulfonyl]?amino]?-?1-?hydroxy-?2-?naphthalenyl]?thio]?- CAS:518303-20-3
