Tolvaptan
- $32 - $2600
- Product name: Tolvaptan
- CAS: 150683-30-0
- MF: C26H25ClN2O3
- MW: 448.94
- EINECS:691-537-5
- MDL Number:MFCD09838782
- Synonyms:N-[4-(9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide;Tolvaptan;N-[4-[(5R)-7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]-3-methylphenyl]-2-methylbenzamide;N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-Methylphenyl)-2-MethylbenzaMide;OPC 41061;OPC-41061;SaMsca;Tolvaptan Tablets
35 prices
Selected condition:
Brand
- Abosyn
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- AvaChem
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Chemtos
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Oakwood
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 10MG
- 50
- 25mg
- 50mg
- 100mg
- 1g
- 5g
- 10g
- ManufacturerAbosyn
- Product number61-2904
- Product descriptionN-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 95%-98%
- Packaging1g
- Price$576
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ20620
- Product descriptionTolvaptan
- Packaging10g
- Price$447
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberB720
- Product descriptionTolvaptan
- Packaging25mg
- Price$152
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0024498
- Product descriptionTOLVAPTAN 95.00%
- Packaging10MG
- Price$190.05
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2300
- Product descriptionTolvaptan
- Packaging50mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2634
- Product descriptionTolvaptan
- Packaging10mg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2634
- Product descriptionTolvaptan
- Packaging100mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2634
- Product descriptionTolvaptan
- Packaging1g
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBT164486
- Product descriptionTolvaptan
- Packaging50mg
- Price$338
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBT164486
- Product descriptionTolvaptan
- Packaging10mg
- Price$126
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19691
- Product descriptionTolvaptan ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19691
- Product descriptionTolvaptan ≥98%
- Packaging5mg
- Price$86
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19691
- Product descriptionTolvaptan ≥98%
- Packaging10mg
- Price$153
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19691
- Product descriptionTolvaptan ≥98%
- Packaging25mg
- Price$335
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM158523
- Product descriptionN-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]-azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 98%
- Packaging10mg
- Price$117
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM158523
- Product descriptionN-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]-azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 98%
- Packaging50mg
- Price$358
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Abosyn | 61-2904 | N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 95%-98% | 1g | $576 | 2021-12-16 | Buy |
AK Scientific | J20620 | Tolvaptan | 10g | $447 | 2021-12-16 | Buy |
AK Scientific | B720 | Tolvaptan | 25mg | $152 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0024498 | TOLVAPTAN 95.00% | 10MG | $190.05 | 2021-12-16 | Buy |
ApexBio Technology | B2300 | Tolvaptan | 50mg | $330 | 2021-12-16 | Buy |
AvaChem | 2634 | Tolvaptan | 10mg | $35 | 2021-12-16 | Buy |
AvaChem | 2634 | Tolvaptan | 100mg | $75 | 2021-12-16 | Buy |
AvaChem | 2634 | Tolvaptan | 1g | $185 | 2021-12-16 | Buy |
Biosynth Carbosynth | BT164486 | Tolvaptan | 50mg | $338 | 2021-12-16 | Buy |
Biosynth Carbosynth | BT164486 | Tolvaptan | 10mg | $126 | 2021-12-16 | Buy |
Cayman Chemical | 19691 | Tolvaptan ≥98% | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 19691 | Tolvaptan ≥98% | 5mg | $86 | 2024-03-01 | Buy |
Cayman Chemical | 19691 | Tolvaptan ≥98% | 10mg | $153 | 2024-03-01 | Buy |
Cayman Chemical | 19691 | Tolvaptan ≥98% | 25mg | $335 | 2024-03-01 | Buy |
Chemenu | CM158523 | N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]-azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 98% | 10mg | $117 | 2021-12-16 | Buy |
Chemenu | CM158523 | N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]-azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 98% | 50mg | $358 | 2021-12-16 | Buy |
Properties
Melting point :219-222°C
Boiling point :594.4±50.0 °C(Predicted)
Density :1.311±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥15mg/mL
form :powder
pka :13.00±0.70(Predicted)
color :white to tan
InChIKey :GYHCTFXIZSNGJT-UHFFFAOYSA-N
SMILES :C(NC1=CC=C(C(N2C3=CC=C(Cl)C=C3C(O)CCC2)=O)C(C)=C1)(=O)C1=CC=CC=C1C
Boiling point :594.4±50.0 °C(Predicted)
Density :1.311±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥15mg/mL
form :powder
pka :13.00±0.70(Predicted)
color :white to tan
InChIKey :GYHCTFXIZSNGJT-UHFFFAOYSA-N
SMILES :C(NC1=CC=C(C(N2C3=CC=C(Cl)C=C3C(O)CCC2)=O)C(C)=C1)(=O)C1=CC=CC=C1C
Safety Information
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Signal word: | Warning | ||||||||||||||||||||||
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Description
Tolvaptan(trade names Samsca and Jinarc) is an oral selective vasopressin antagonist developed by Otsuka for the treatment of hyponatremia, and it is a non-peptide selective antidiuretic hormone receptor antagonist. The drug can increase the concentration of sodium ions in the plasma, and help the excess water discharge from the urine. The drug could enhance the ability of the kidney to deal with water, and significantly reduce the weight and edema of patients while not accompanied by increased electrolyte excretion, without destroying the blood electrolyte balance. The drug can be used to treat hyponatremia caused by congestive heart failure, various edematous diseases, cirrhosis and antidiuretic hormone deficiency syndrome. The study found that, when the plasma sodium concentration decreased, in order to maintain the balance of sodium concentration inside and outside the cell, extracellular fluid will enter the cell, so the cells will swell. When the brain cells swell, it will lead to a variety of hyponatremia symptoms, including dizziness, weakness, headache, nausea, confusion, consciousness and convulsions. Severe hyponatremia can lead to coma and death. There is no corresponding study of tolvaptan tablets in patients with severe hyponatremia.Related product price
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Suppliers and manufacturers
Beijing Cooperate Pharmaceutical Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
SHANDONG ZHI SHANG CHEMICAL CO.LTD
Shenzhen Nexconn Pharmatechs Ltd