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ChemicalBook >> CAS DataBase List >> Tiotropium bromide

Tiotropium bromide

Tiotropium bromide price.
  • $27 - $12308
  • Product name: Tiotropium bromide
  • CAS: 136310-93-5
  • MF: C19H22BrNO4S2
  • MW: 472.42
  • EINECS:680-665-7
  • MDL Number:MFCD00867027
  • Synonyms:Anhydrous Tiotropium Bromide;3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide (1:1), (1α,2β,4β,5α,7β)-;(1α，2β，4β，5α，7β-7-[(Hydroxydi-2-thienylacetyl)oxy]-9，9-dimethyl-3-oxa-9-azoniatricyclo[3．3．1．0^<2,4>^]nonane bromide;Ba-679;Ba-679 BR;otropiuM broMide;(1R,2S,4R,5S,7R)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-diMethyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-9-iuM broMide;TiotropiuM BroMide(Spiriva, BA 679BR)
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  • AHH
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
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  • 100g
  • 10mM(in 1mL DMSO)
  • ManufacturerAHH
  • Product numberMT-59531
  • Product descriptionTiotropium Bromide 99%
  • Packaging0.5g
  • Price$680
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberA626
  • Product descriptionTiotropium Bromide
  • Packaging25mg
  • Price$34
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA166270
  • Product descriptionrel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide 98+%
  • Packaging10mg
  • Price$27
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA166270
  • Product descriptionrel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide 98+%
  • Packaging25mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA166270
  • Product descriptionrel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide 98+%
  • Packaging50mg
  • Price$79
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA166270
  • Product descriptionrel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide 98+%
  • Packaging100mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA166270
  • Product descriptionrel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide 98+%
  • Packaging250mg
  • Price$177
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA166270
  • Product descriptionrel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide 98+%
  • Packaging1g
  • Price$400
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0006410
  • Product descriptionTIOTROPIUM BROMIDE 95.00%
  • Packaging1MG
  • Price$177.45
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0006410
  • Product descriptionTIOTROPIUM BROMIDE 95.00%
  • Packaging5MG
  • Price$234.3
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3874
  • Product descriptionTiotropium Bromide
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3874
  • Product descriptionTiotropium Bromide
  • Packaging100mg
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS460840
  • Product descriptionrel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide ≥98%
  • Packaging100mg
  • Price$309
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS460840
  • Product descriptionrel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide ≥98%
  • Packaging250mg
  • Price$463
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS460840
  • Product descriptionrel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide ≥98%
  • Packaging1g
  • Price$1157
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2984
  • Product descriptionTiotropium Bromide
  • Packaging5g
  • Price$1190
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH MT-59531 Tiotropium Bromide 99% 0.5g $680 2021-12-16 Buy
AK Scientific A626 Tiotropium Bromide 25mg $34 2021-12-16 Buy
Ambeed A166270 rel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide 98+% 10mg $27 2021-12-16 Buy
Ambeed A166270 rel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide 98+% 25mg $49 2021-12-16 Buy
Ambeed A166270 rel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide 98+% 50mg $79 2021-12-16 Buy
Ambeed A166270 rel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide 98+% 100mg $110 2021-12-16 Buy
Ambeed A166270 rel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide 98+% 250mg $177 2021-12-16 Buy
Ambeed A166270 rel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide 98+% 1g $400 2021-12-16 Buy
American Custom Chemicals Corporation API0006410 TIOTROPIUM BROMIDE 95.00% 1MG $177.45 2021-12-16 Buy
American Custom Chemicals Corporation API0006410 TIOTROPIUM BROMIDE 95.00% 5MG $234.3 2021-12-16 Buy
ApexBio Technology A3874 Tiotropium Bromide 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology A3874 Tiotropium Bromide 100mg $133 2021-12-16 Buy
Arctom AS460840 rel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide ≥98% 100mg $309 2021-12-16 Buy
Arctom AS460840 rel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide ≥98% 250mg $463 2021-12-16 Buy
Arctom AS460840 rel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumbromide ≥98% 1g $1157 2021-12-16 Buy
AvaChem 2984 Tiotropium Bromide 5g $1190 2021-12-16 Buy

Properties

Melting point :218-2200C
storage temp. :Inert atmosphere,2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White to Off-White
λmax :240nm(lit.)
Merck :14,9454
CAS DataBase Reference :136310-93-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Tiotropium is a long-acting muscarinic receptor antagonist used as a bronchodilator in the treatment of chronic obstructive pulmonary disease. It binds equally to human muscarinic M1, M2, and M3 receptors (Kds = 0.04, 0.02, and 0.01 nM, respectively), dissociating slowly from M1 and M3 receptors, which are located on bronchial smooth muscle and submucosal glands, and more rapidly from M2 receptors (t? = 14.6 and 34.7 versus 3.6 hours, respectively).

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