SH-4-54
|
- $32 - $1900
- Product name: SH-4-54
- CAS: 1456632-40-8
- MF: C29H27F5N2O5S
- MW: 610.59
- EINECS:
- MDL Number:MFCD28143917
- Synonyms:4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-Benzoic Acid SH-4-54;SH-4-54;4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-benzoic acid;Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-;CS-1773;SH-4-54 USP/EP/BP;SH 4 54,Inhibitor,SH454,inhibit,STAT
25 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Arctom
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 2mg
- 2.5mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2716AH
- Product descriptionSH-4-54
- Packaging5mg
- Price$177
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2716AH
- Product descriptionSH-4-54
- Packaging250mg
- Price$1262
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004689
- Product descriptionSH-4-54 95.00%
- Packaging5MG
- Price$505.7
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60120
- Product descriptionSH-4-54
- Packaging10mg
- Price$478
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number25982
- Product descriptionSH-4-54 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25982
- Product descriptionSH-4-54 ≥98%
- Packaging5mg
- Price$109
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25982
- Product descriptionSH-4-54 ≥98%
- Packaging10mg
- Price$199
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25982
- Product descriptionSH-4-54 ≥98%
- Packaging25mg
- Price$381
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-4597
- Product descriptionSH-4-54 99.59%
- Packaging2mg
- Price$114
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4597
- Product descriptionSH-4-54 99.59%
- Packaging5mg
- Price$168
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4597
- Product descriptionSH-4-54 99.59%
- Packaging10mg
- Price$264
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4597
- Product descriptionSH-4-54 99.59%
- Packaging25mg
- Price$528
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4597
- Product descriptionSH-4-54 99.59%
- Packaging50mg
- Price$780
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4597
- Product descriptionSH-4-54 99.59%
- Packaging100mg
- Price$1092
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003422
- Product descriptionSH-4-54 98+%
- Packaging10mg
- Price$226
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003422
- Product descriptionSH-4-54 98+%
- Packaging25mg
- Price$451
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2716AH | SH-4-54 | 5mg | $177 | 2021-12-16 | Buy |
| AK Scientific | 2716AH | SH-4-54 | 250mg | $1262 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004689 | SH-4-54 95.00% | 5MG | $505.7 | 2021-12-16 | Buy |
| Arctom | CFN60120 | SH-4-54 | 10mg | $478 | 2021-12-16 | Buy |
| Cayman Chemical | 25982 | SH-4-54 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 25982 | SH-4-54 ≥98% | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 25982 | SH-4-54 ≥98% | 10mg | $199 | 2024-03-01 | Buy |
| Cayman Chemical | 25982 | SH-4-54 ≥98% | 25mg | $381 | 2024-03-01 | Buy |
| ChemScene | CS-4597 | SH-4-54 99.59% | 2mg | $114 | 2021-12-16 | Buy |
| ChemScene | CS-4597 | SH-4-54 99.59% | 5mg | $168 | 2021-12-16 | Buy |
| ChemScene | CS-4597 | SH-4-54 99.59% | 10mg | $264 | 2021-12-16 | Buy |
| ChemScene | CS-4597 | SH-4-54 99.59% | 25mg | $528 | 2021-12-16 | Buy |
| ChemScene | CS-4597 | SH-4-54 99.59% | 50mg | $780 | 2021-12-16 | Buy |
| ChemScene | CS-4597 | SH-4-54 99.59% | 100mg | $1092 | 2021-12-16 | Buy |
| Crysdot | CD31003422 | SH-4-54 98+% | 10mg | $226 | 2021-12-16 | Buy |
| Crysdot | CD31003422 | SH-4-54 98+% | 25mg | $451 | 2021-12-16 | Buy |
Properties
Boiling point :717.2±70.0 °C(Predicted)
Density :1.431±0.06 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml
form :A crystalline solid
pka :4.29±0.10(Predicted)
color :White to off-white
Density :1.431±0.06 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml
form :A crystalline solid
pka :4.29±0.10(Predicted)
color :White to off-white
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
SH-4-54 is an inhibitor of signal transducer and activator of transcription 3 (STAT3; IC50 = 4.7 μM for STAT3 homodimer DNA binding activity). It selectively inhibits STAT3 homodimer over STAT1 and STAT5 homodimer and STAT3:STAT1 heterodimer DNA binding in EGF-stimulated NIH3T3/hEGFR nuclear extracts containing activated STAT1, STAT3, and STAT5 and decreases STAT3 iNOS, Survivin, and Bcl-2 promoter occupancy in MDA-MB-231 cells. SH-4-54 inhibits growth of glioma, breast, and prostate cancer cell lines that express constitutively active STAT3 (IC50s = 1-7.4, 3.8-4.5, and 5.3-5.8 μM, respectively). In vivo, SH-4-54 (3 mg/kg per day) inhibits tumor growth in the U251MG glioma and MDA-MB-231 breast cancer mouse xenograft models.Related product price
- 936091-26-8
$28-3250 - HO-3867
$57-2395.3 - EW-7197
$70-7560
