SC 66
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- $15 - $1190
- Product name: SC 66
- CAS: 871361-88-5
- MF: C18H16N2O
- MW: 276.33
- EINECS:
- MDL Number:MFCD05025493
- Synonyms:SC 66;Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-;(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone;CS-2480;SC66;SC 66;(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone;Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis;2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA
36 prices
Selected condition：
Brand
- Ambeed
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Tocris
- TRC
- Usbiological
Package
- 10
- 5mg
- 10mg
- 25mg
- 50
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAmbeed
- Product numberA225521
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+%
- Packaging5mg
- Price$51
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA225521
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+%
- Packaging10mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA225521
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+%
- Packaging25mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA225521
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+%
- Packaging50mg
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA225521
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+%
- Packaging250mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA225521
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+%
- Packaging1g
- Price$1190
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5575
- Product descriptionSC66
- Packaging5mg
- Price$87
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5575
- Product descriptionSC66
- Packaging10mg
- Price$122
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5575
- Product descriptionSC66
- Packaging50mg
- Price$394
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5575
- Product descriptionSC66
- Packaging100mg
- Price$630
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS022751
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone ≥98%
- Packaging5mg
- Price$15
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS022751
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone ≥98%
- Packaging10mg
- Price$20
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS022751
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone ≥98%
- Packaging25mg
- Price$26
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS022751
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone ≥98%
- Packaging50mg
- Price$34
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS022751
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone ≥98%
- Packaging100mg
- Price$48
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS022751
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone ≥98%
- Packaging250mg
- Price$92
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Ambeed | A225521 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+% | 5mg | $51 | 2021-12-16 | Buy |
| Ambeed | A225521 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+% | 10mg | $95 | 2021-12-16 | Buy |
| Ambeed | A225521 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+% | 25mg | $160 | 2021-12-16 | Buy |
| Ambeed | A225521 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+% | 50mg | $208 | 2021-12-16 | Buy |
| Ambeed | A225521 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+% | 250mg | $350 | 2021-12-16 | Buy |
| Ambeed | A225521 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+% | 1g | $1190 | 2021-12-16 | Buy |
| ApexBio Technology | B5575 | SC66 | 5mg | $87 | 2021-12-16 | Buy |
| ApexBio Technology | B5575 | SC66 | 10mg | $122 | 2021-12-16 | Buy |
| ApexBio Technology | B5575 | SC66 | 50mg | $394 | 2021-12-16 | Buy |
| ApexBio Technology | B5575 | SC66 | 100mg | $630 | 2021-12-16 | Buy |
| Arctom | AS022751 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone ≥98% | 5mg | $15 | 2021-12-16 | Buy |
| Arctom | AS022751 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone ≥98% | 10mg | $20 | 2021-12-16 | Buy |
| Arctom | AS022751 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone ≥98% | 25mg | $26 | 2021-12-16 | Buy |
| Arctom | AS022751 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone ≥98% | 50mg | $34 | 2021-12-16 | Buy |
| Arctom | AS022751 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone ≥98% | 100mg | $48 | 2021-12-16 | Buy |
| Arctom | AS022751 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone ≥98% | 250mg | $92 | 2021-12-16 | Buy |
Properties
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥5mg/mL (warmed)
form :powder
color :faint yellow to dark yellow
solubility :DMSO: ≥5mg/mL (warmed)
form :powder
color :faint yellow to dark yellow
Safety Information
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Description
Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP3) or phosphatidylinositol-3,4-bisphosphate (PIP2). Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer. Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. At 4 μg/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death. In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth.Related product price
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