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ChemicalBook >> CAS DataBase List >> Roflumilast

Roflumilast

Roflumilast price.
  • $5 - $1789
  • Product name: Roflumilast
  • CAS: 162401-32-3
  • MF: C17H14Cl2F2N2O3
  • MW: 403.21
  • EINECS:685-382-2
  • MDL Number:MFCD00938270
  • Synonyms:ROFLUMILAST;3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide;B 9302-107;BY 217;BYK 20869;Daxas;Roflumilast / 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide;3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
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  • AK Scientific
  • Ambeed
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  • ApexBio Technology
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  • Cayman Chemical
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Package
  • 5mg
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  • 1mg
  • 10mM(in 1mL DMSO)
  • 10mg
  • 50
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  • 250mg
  • 1g
  • 5g
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  • ManufacturerAK Scientific
  • Product numberJ11524
  • Product descriptionRoflumilast
  • Packaging25mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ11524
  • Product descriptionRoflumilast
  • Packaging100mg
  • Price$98
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ90119
  • Product descriptionRoflumilast
  • Packaging5g
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA168666
  • Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
  • Packaging5mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA168666
  • Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
  • Packaging10mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA168666
  • Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
  • Packaging50mg
  • Price$8
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA168666
  • Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
  • Packaging250mg
  • Price$13
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA168666
  • Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
  • Packaging1g
  • Price$34
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA168666
  • Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
  • Packaging5g
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA168666
  • Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
  • Packaging25g
  • Price$542
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA168666
  • Product description3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+%
  • Packaging100g
  • Price$1789
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004090
  • Product descriptionROFLUMILAST 95.00%
  • Packaging1G
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4319
  • Product descriptionRoflumilast
  • Packaging5mg
  • Price$63
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4319
  • Product descriptionRoflumilast
  • Packaging10mM(in 1mL DMSO)
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4319
  • Product descriptionRoflumilast
  • Packaging10mg
  • Price$119
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4319
  • Product descriptionRoflumilast
  • Packaging25mg
  • Price$259
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J11524 Roflumilast 25mg $49 2021-12-16 Buy
AK Scientific J11524 Roflumilast 100mg $98 2021-12-16 Buy
AK Scientific J90119 Roflumilast 5g $120 2021-12-16 Buy
Ambeed A168666 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% 5mg $5 2021-12-16 Buy
Ambeed A168666 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% 10mg $6 2021-12-16 Buy
Ambeed A168666 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% 50mg $8 2021-12-16 Buy
Ambeed A168666 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% 250mg $13 2021-12-16 Buy
Ambeed A168666 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% 1g $34 2021-12-16 Buy
Ambeed A168666 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% 5g $133 2021-12-16 Buy
Ambeed A168666 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% 25g $542 2021-12-16 Buy
Ambeed A168666 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 99+% 100g $1789 2021-12-16 Buy
American Custom Chemicals Corporation API0004090 ROFLUMILAST 95.00% 1G $210 2021-12-16 Buy
ApexBio Technology A4319 Roflumilast 5mg $63 2021-12-16 Buy
ApexBio Technology A4319 Roflumilast 10mM(in 1mL DMSO) $80 2021-12-16 Buy
ApexBio Technology A4319 Roflumilast 10mg $119 2021-12-16 Buy
ApexBio Technology A4319 Roflumilast 25mg $259 2021-12-16 Buy

Properties

Melting point :158°C
Boiling point :430.6±45.0 °C(Predicted)
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
pka :9.89±0.70(Predicted)
form :powder
color :white to beige
Merck :14,8249
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
InChIKey :MNDBXUUTURYVHR-UHFFFAOYSA-N
SMILES :C(NC1C(Cl)=CN=CC=1Cl)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
CAS DataBase Reference :162401-32-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Type 4 cyclic nucleotide phosphodiesterase (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. Roflumilast is a potent, cell-permeable inhibitor of PDE4 (IC50 = < 1 nM for both human PDE4B and PDE4D). It is selective for PDE4, with IC50 values against other PDE forms being greater than 10 μM. Roflumilast demonstrates good bioavailability and has applications in respiratory diseases, including asthma and chronic obstructive pulmonary disease.

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