Structure of Roflumilast
CAS No.: 162401-32-3
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Roflumilast is a selective and long-acting inhibitor of PDE-4 with IC50 of 0.8 nM.
Synonyms: APTA-2217; BYK 20869; Daliresp
4.5
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Sohn, Jeferson ;
Abstract: Fear memory retrieval is at the core of signs and symptoms of post-traumatic stress disorder (PTSD) a psychiatric disease induced by extreme life-threatening events. Short RET induces reconsolidation, which upholds the original fear memory, while long retrieval triggers extinction, inhibiting the original fear memory expression. These processes engage neural circuits involving the dorsal hippocampus (DH) and medial prefrontal cortex regions like the pre-limbic cortex (PL). Additionally, these processes activate intracellular signaling pathways, such as those involving cyclic adenosine monophosphate (cAMP). Phosphodiesterase 4 (PDE4) regulates this pathway by degrading cAMP. Inhibiting PDE4 has been suggested as a strategy to alter memory processing. However, the role of PDE4 after a short fear memory retrieval remains unknown. Advancing this knowledge may contribute to the development of novel treatments for PTSD aimed at modifying memory reconsolidation or extinction. This study aimed to evaluate whether PDE4 inhibition after a short retrieval alters the behavioral outcomes induced by retrieval. For this purpose, adult male Wistar rats were exposed to contextual fear conditioning. After a short retrieval session, the animals were treated with roflumilast (ROF; a PDE4 inhibitor) i.p. at doses of 0.01, 0.03, 0.1, or 0.3 mg/kg 5, 30 min, or 3 h after memory retrieval. After 1 and 10 days, the animals were re-exposed (3 min) to the conditioned context for Tests A1 and A2, respectively. Whereas no changes were observed during Test A1, the treatment with ROF 0.1 i.p. 5 min after retrieval significantly reduced freezing behavior in Test A2 suggesting a specific long-term effect. The expression of cAMP-response element binding (CREB), Brain-derived neurotrophic factor (BDNF), Zinc finger 268 (Zif268), or protein kinase Mζ (PKMζ) in the DH and the PL after retrieval, Test A1, and A2 were evaluated to assess the role of these proteins in memory regulation. The treatment with ROF 0.1 5 min after retrieval increased the expression of proBDNF (16 kDa) in the DH after Test A1 and reduced Zif268 expression in the PL after Test A2. To understand the role of the DH and the PL in the observed effects, ROF (9 ng/0.5 or 0.2 μL) was administered 5 min after retrieval directly into these regions. Accordingly, PDE4 inhibition (both involving PDE4B and PDE4D subtypes) in the DH significantly reduced freezing behavior in Test A2. Omitting the retrieval session or Test A1 reversed the ROF effects, indicating the effects depend on exposure to the conditioned context. Moreover, both extending the interval between retrieval and Test A1, inhibiting protein kinase A (PKA; after retrieval), or inhibiting protein synthesis (after Test A1) abolished the effects induced by ROF in the DH. The treatment with ROF in the DH induced effects sensitive to reinstatement and facilitated extinction in the day after treatment, favoring the interpretation that the effects of ROF after a short retrieval session are related to extinction but not reconsolidation. However, ROF administered directly in the PL sustained fear expression in Test A1, whereas there were no significant differences in Test A2. Therefore, it was evaluated whether ROF treatment after conditioning favors fear memory. However, treatment with 0.1 ROF i.p. impaired fear memory consolidation in weak training. To evaluate whether the same pattern of results occurred in another type of memory, the effects of ROF treatment on object recognition memory were assessed. Treatment with 0.1 ROF i.p. improved reconsolidation when administered 5 min after the retrieval and improved consolidation when administered 3 h after training. The results suggest that inhibiting PDE4 after a short retrieval induces, upon re-exposure to the conditioned context, memory extinction at a time that typically leads to reconsolidation. This effect is PKA-dependent and related to increased proBDNF in the DH. The results of this study suggest that after a short fear memory retrieval, it is possible to modify the memory fate from reconsolidation to extinction, a mechanism that involves PDE4 inhibition.
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CAS No. : | 162401-32-3 |
Formula : | C17H14Cl2F2N2O3 |
M.W : | 403.21 |
SMILES Code : | O=C(NC1=C(Cl)C=NC=C1Cl)C2=CC=C(OC(F)F)C(OCC3CC3)=C2 |
Synonyms : |
APTA-2217; BYK 20869; Daliresp
|
MDL No. : | MFCD00938270 |
InChI Key : | MNDBXUUTURYVHR-UHFFFAOYSA-N |
Pubchem ID : | 449193 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Target |
|
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03762330 | Chronic Obstructive Pulmonary ... More >>Disease Less << | Not Applicable | Not yet recruiting | January 2021 | - |
NCT02835716 | - | Recruiting | September 2020 | United States, Connecticut ... More >> Millennium Magnetic Technologies, LLC Recruiting Westport, Connecticut, United States, 06880 Contact: Steve Levy, MD ?? 203-423-9494 ?? SL@MilMag.net ?? Contact: Donald H Marks, MD PhD ?? 9733070364 ?? DHM@MilMag.net Less << | |
NCT01730404 | COPD | Phase 2 | Completed | - | Ireland ... More >> Celerion Belfast, Ireland United Kingdom Parexel, early phases Harrow, United Kingdom Medicines Evaluation Unit Ltd Manchester, United Kingdom Freeman Hospital Newcastle, United Kingdom Nottingham University Hospitals NHS Trust Nottingham, United Kingdom Less << |
NCT00613587 | - | Completed | - | United States, Nebraska ... More >> Creighton University Medical Center Omaha, Nebraska, United States, 68131 Less << | |
NCT02363335 | Healthy Volunteers | Phase 1 | Completed | - | United States, Maryland ... More >> National Institute of Aging, Clinical Research Unit Baltimore, Maryland, United States, 21224 Less << |
NCT01580748 | Symptomatic Bronchiectasis | PHASE2 | UNKNOWN | 2025-01-13 | Seoul National University Bund... More >>ang Hospital, Seongnam, Gyeongi-do, 463-707, Korea, Republic of Less << |
NCT02340520 | - | Completed | - | - | |
NCT00242294 | Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << | PHASE2|PHASE3 | COMPLETED | 2025-03-07 | Nycomed Japan and Mitsubishi T... More >>anabe Oharma Corporation, Osaka, Japan Less << |
NCT02340520 | COPD | Phase 3 | Completed | - | United States, Connecticut ... More >> UConnHealth Farmington, Connecticut, United States, 06032 Less << |
NCT00108823 | Chronic Obstructive Pulmonary ... More >>Disease, COPD Less << | PHASE3 | COMPLETED | - | ALTANA Pharma, Cities in Calif... More >>ornia, California, United States|ALTANA Pharma, Cities in Colorado, Colorado, United States|ALTANA Pharma, Cities in Florida, Florida, United States|ALTANA Pharma, Cities in Missouri, Missouri, United States|ALTANA Pharma, Cities in New Mexico, New Mexico, United States|ALTANA Pharma, Cities in New York, New York, United States|ALTANA Pharma, Cities in Oregeon, Oregon, United States|ALTANA Pharma, Cities in South Carolina, South Carolina, United States|ALTANA Pharma, Cities in Texas, Texas, United States|ALTANA Pharma, Cities in Washington, Washington, United States|ALTANA Pharma, Cities in Canada, Canada|ALTANA Pharma, Cities in France, France|ALTANA Pharma, Cities in Poland, Poland|ALTANA Pharma, Cities in South Africa, South Africa|ALTANA Pharma, Cities in Spain, Spain|ALTANA Pharma, Cities in the United Kingdom, United Kingdom Less << |
NCT01285180 | - | Completed | - | - | |
NCT01285167 | Chronic Obstructive Pulmonary ... More >>Disease Less << | COMPLETED | 2025-02-12 | Nycomed Deutschland GmbH, Ahle... More >>n, 59227, Germany|Nycomed Deutschland GmbH, Ahlen, 59229, Germany|Nycomed Deutschland GmbH, Allendorf, 35108, Germany|Nycomed Deutschland GmbH, Allersberg, 90584, Germany|Nycomed Deutschland GmbH, Alpenrod, 57642, Germany|Nycomed Deutschland GmbH, Altena, 58762, Germany|Nycomed Deutschland GmbH, Altenburg, 04600, Germany|Nycomed Deutschland GmbH, Alzenau, 63755, Germany|Nycomed Deutschland GmbH, Alzey, 55232, Germany|Nycomed Deutschland GmbH, Amberg, 92224, Germany|Nycomed Deutschland GmbH, Anklam, 17389, Germany|Nycomed Deutschland GmbH, Annaberg-Buchholz, 09456, Germany|Nycomed Deutschland GmbH, Arnsberg, 59821, Germany|Nycomed Deutschland GmbH, Aschaffenburg, 63739, Germany|Nycomed Deutschland GmbH, Aschaffenburg, 63743, Germany|Nycomed Deutschland GmbH, Attendorn, 57439, Germany|Nycomed Deutschland GmbH, Attenkirchen, 85395, Germany|Nycomed Deutschland GmbH, Auerbach, 08209, Germany|Nycomed Deutschland GmbH, Augsburg, 86150, Germany|Nycomed Deutschland GmbH, Augsburg, 86156, Germany|Nycomed Deutschland GmbH, Backnang, 71522, Germany|Nycomed Deutschland GmbH, Bad Doberan, 18209, Germany|Nycomed Deutschland GmbH, Bad Endorf, 83093, Germany|Nycomed Deutschland GmbH, Bad Essen, 49152, Germany|Nycomed Deutschland GmbH, Bad Freienwalde, 16259, Germany|Nycomed Deutschland GmbH, Bad Füssing, 94072, Germany|Nycomed Deutschland GmbH, Bad Honnef, 53604, Germany|Nycomed Deutschland GmbH, Bad Langensalza, 99947, Germany|Nycomed Deutschland GmbH, Bad Lippspringe, 33175, Germany|Nycomed Deutschland GmbH, Bad Reichenhall, 83435, Germany|Nycomed Deutschland GmbH, Bad Salzuflen, 32105, Germany|Nycomed Deutschland GmbH, Bad Salzuflen, 32108, Germany|Nycomed Deutschland GmbH, Bad Salzungen, 36433, Germany|Nycomed Deutschland GmbH, Bad Soden-Salmünster, 63628, Germany|Nycomed Deutschland GmbH, Bad Soden, 65812, Germany|Nycomed Deutschland GmbH, Bad Tennstedt, 99955, Germany|Nycomed Deutschland GmbH, Bad W?rishofen, 86825, Germany|Nycomed Deutschland GmbH, Badel, 39624, Germany|Nycomed Deutschland GmbH, Baden-Baden, 76530, Germany|Nycomed Deutschland GmbH, Bamberg, 96047, Germany|Nycomed Deutschland GmbH, Bamberg, 96049, Germany|Nycomed Deutschland GmbH, Bargteheide, 22941, Germany|Nycomed Deutschland GmbH, Baunatal, 34225, Germany|Nycomed Deutschland GmbH, Bausendorf, 54538, Germany|Nycomed Deutschland GmbH, Bautzen, 02625, Germany|Nycomed Deutschland GmbH, Beelitz, 14547, Germany|Nycomed Deutschland GmbH, Bensheim, 64625, Germany|Nycomed Deutschland GmbH, Bergisch Gladbach, 51429, Germany|Nycomed Deutschland GmbH, Bergisch Gladbach, 51465, Germany|Nycomed Deutschland GmbH, Bergkamen, 59192, Germany|Nycomed Deutschland GmbH, Bergneustadt, 51702, Germany|Nycomed Deutschland GmbH, Berlin, 10117, Germany|Nycomed Deutschland GmbH, Berlin, 10247, Germany|Nycomed Deutschland GmbH, Berlin, 10318, Germany|Nycomed Deutschland GmbH, Berlin, 10365, Germany|Nycomed Deutschland GmbH, Berlin, 10367, Germany|Nycomed Deutschland GmbH, Berlin, 10559, Germany|Nycomed Deutschland GmbH, Berlin, 10625, Germany|Nycomed Deutschland GmbH, Berlin, 10627, Germany|Nycomed Deutschland GmbH, Berlin, 10711, Germany|Nycomed Deutschland GmbH, Berlin, 10717, Germany|Nycomed Deutschland GmbH, Berlin, 10789, Germany|Nycomed Deutschland GmbH, Berlin, 10961, Germany|Nycomed Deutschland GmbH, Berlin, 12043, Germany|Nycomed Deutschland GmbH, Berlin, 12099, Germany|Nycomed Deutschland GmbH, Berlin, 12157, Germany|Nycomed Deutschland GmbH, Berlin, 12165, Germany|Nycomed Deutschland GmbH, Berlin, 12203, Germany|Nycomed Deutschland GmbH, Berlin, 12279, Germany|Nycomed Deutschland GmbH, Berlin, 12555, Germany|Nycomed Deutschland GmbH, Berlin, 12627, Germany|Nycomed Deutschland GmbH, Berlin, 12679, Germany|Nycomed Deutschland GmbH, Berlin, 12687, Germany|Nycomed Deutschland GmbH, Berlin, 13055, Germany|Nycomed Deutschland GmbH, Berlin, 13057, Germany|Nycomed Deutschland GmbH, Berlin, 13156, Germany|Nycomed Deutschland GmbH, Berlin, 13187, Germany|Nycomed Deutschland GmbH, Berlin, 13353, Germany|Nycomed Deutschland GmbH, Berlin, 13405, Germany|Nycomed Deutschland GmbH, Berlin, 13465, Germany|Nycomed Deutschland GmbH, Berlin, 13507, Germany|Nycomed Deutschland GmbH, Berlin, 13581, Germany|Nycomed Deutschland GmbH, Berlin, 14052, Germany|Nycomed Deutschland GmbH, Berlin, 14059, Germany|Nycomed Deutschland GmbH, Bernau, 16321, Germany|Nycomed Deutschland GmbH, Biedenkopf, 35216, Germany|Nycomed Deutschland GmbH, Bielefeld, 33647, Germany|Nycomed Deutschland GmbH, Bietigheim-Bissingen, 74321, Germany|Nycomed Deutschland GmbH, Bitterfeld, 06749, Germany|Nycomed Deutschland GmbH, Blankenhain, 99444, Germany|Nycomed Deutschland GmbH, Bochum, 44866, Germany|Nycomed Deutschland GmbH, Bochum, 44879, Germany|Nycomed Deutschland GmbH, Bondorf, 71149, Germany|Nycomed Deutschland GmbH, Bonndorf, 79848, Germany|Nycomed Deutschland GmbH, Bonn, 53111, Germany|Nycomed Deutschland GmbH, Bonn, 53113, Germany|Nycomed Deutschland GmbH, Bonn, 53119, Germany|Nycomed Deutschland GmbH, Bonn, 53123, Germany|Nycomed Deutschland GmbH, Bonn, 53225, Germany|Nycomed Deutschland GmbH, Bottrop, 46236, Germany|Nycomed Deutschland GmbH, Bottrop, 46240, Germany|Nycomed Deutschland GmbH, Bovenden, 37120, Germany|Nycomed Deutschland GmbH, Braunfels, 35619, Germany|Nycomed Deutschland GmbH, Braunsbedra, 06242, Germany|Nycomed Deutschland GmbH, Braunschweig, 38100, Germany|Nycomed Deutschland GmbH, Braunschweig, 38106, Germany|Nycomed Deutschland GmbH, Bredstedt, 25821, Germany|Nycomed Deutschland GmbH, Breitengü?bach, 96149, Germany|Nycomed Deutschland GmbH, Bremerhaven, 27570, Germany|Nycomed Deutschland GmbH, Bremerhaven, 27578, Germany|Nycomed Deutschland GmbH, Bremerhaven, 27580, Germany|Nycomed Deutschland GmbH, Brilon, 59929, Germany|Nycomed Deutschland GmbH, Bruchsal, 76646, Germany|Nycomed Deutschland GmbH, Brunsbüttel, 25541, Germany|Nycomed Deutschland GmbH, Buckow, 15377, Germany|Nycomed Deutschland GmbH, Bunde, 26831, Germany|Nycomed Deutschland GmbH, Burgau, 89331, Germany|Nycomed Deutschland GmbH, Burgst?dt, 09217, Germany|Nycomed Deutschland GmbH, Burgwedel, 30938, Germany|Nycomed Deutschland GmbH, Büchen, 21514, Germany|Nycomed Deutschland GmbH, Büddenstedt, 38372, Germany|Nycomed Deutschland GmbH, Bünde, 32257, Germany|Nycomed Deutschland GmbH, Calau, 03205, Germany|Nycomed Deutschland GmbH, Callenberg, 09337, Germany|Nycomed Deutschland GmbH, Camburg, 07774, Germany|Nycomed Deutschland GmbH, Celle, 29221, Germany|Nycomed Deutschland GmbH, Chemnitz, 09126, Germany|Nycomed Deutschland GmbH, Coburg, 96450, Germany|Nycomed Deutschland GmbH, Cottbus, 03050, Germany|Nycomed Deutschland GmbH, Crimmitschau, 08451, Germany|Nycomed Deutschland GmbH, Darmstadt, 64287, Germany|Nycomed Deutschland GmbH, Deggendorf, 94469, Germany|Nycomed Deutschland GmbH, Deggingen, 73326, Germany|Nycomed Deutschland GmbH, Dessau, 06844, Germany|Nycomed Deutschland GmbH, Dessau, 06846, Germany|Nycomed Deutschland GmbH, Dillingen, 66763, Germany|Nycomed Deutschland GmbH, Dillingen, 89407, Germany|Nycomed Deutschland GmbH, Dinslaken, 46535, Germany|Nycomed Deutschland GmbH, Dommitzsch, 04880, Germany|Nycomed Deutschland GmbH, Dornstetten, 72280, Germany|Nycomed Deutschland GmbH, Dorsten, 46284, Germany|Nycomed Deutschland GmbH, Dortmund, 44135, Germany|Nycomed Deutschland GmbH, Dortmund, 44388, Germany|Nycomed Deutschland GmbH, Dresden, 01099, Germany|Nycomed Deutschland GmbH, Dresden, 01187, Germany|Nycomed Deutschland GmbH, Dresden, 01307, Germany|Nycomed Deutschland GmbH, Duisburg, 47137, Germany|Nycomed Deutschland GmbH, Duisburg, 47198, Germany|Nycomed Deutschland GmbH, D?rentrup, 32694, Germany|Nycomed Deutschland GmbH, Düren, 52349, Germany|Nycomed Deutschland GmbH, Düsseldorf, 40211, Germany|Nycomed Deutschland GmbH, Düsseldorf, 40217, Germany|Nycomed Deutschland GmbH, Düsseldorf, 40231, Germany|Nycomed Deutschland GmbH, Düsseldorf, 40237, Germany|Nycomed Deutschland GmbH, Düsseldorf, 40489, Germany|Nycomed Deutschland GmbH, Eberswalde, 16225, Germany|Nycomed Deutschland GmbH, Eggenfelden, 84307, Germany|Nycomed Deutschland GmbH, Ehra-Lessien, 38468, Germany|Nycomed Deutschland GmbH, Ehrenkirchen, 79238, Germany|Nycomed Deutschland GmbH, Einbeck, 37574, Germany|Nycomed Deutschland GmbH, Eisenach, 99817, Germany|Nycomed Deutschland GmbH, Ellerstadt, 67158, Germany|Nycomed Deutschland GmbH, Ellrich, 99755, Germany|Nycomed Deutschland GmbH, Ellwangen (Jagst), 73479, Germany|Nycomed Deutschland GmbH, Emsdetten, 48282, Germany|Nycomed Deutschland GmbH, Emskirchen, 91448, Germany|Nycomed Deutschland GmbH, Ennepetal, 58256, Germany|Nycomed Deutschland GmbH, Erfde, 24803, Germany|Nycomed Deutschland GmbH, Erfurt, 99084, Germany|Nycomed Deutschland GmbH, Erfurt, 99086, Germany|Nycomed Deutschland GmbH, Erfurt, 99089, Germany|Nycomed Deutschland GmbH, Erfurt, 99099, Germany|Nycomed Deutschland GmbH, Erlangen, 91052, Germany|Nycomed Deutschland GmbH, Eschau, 63863, Germany|Nycomed Deutschland GmbH, Eschwege, 37269, Germany|Nycomed Deutschland GmbH, Eschweiler, 52249, Germany|Nycomed Deutschland GmbH, Essenheim, 55270, Germany|Nycomed Deutschland GmbH, Essen, 45127, Germany|Nycomed Deutschland GmbH, Essen, 45131, Germany|Nycomed Deutschland GmbH, Essen, 45279, Germany|Nycomed Deutschland GmbH, Essen, 45307, Germany|Nycomed Deutschland GmbH, Essen, 45329, Germany|Nycomed Deutschland GmbH, Essen, 45355, Germany|Nycomed Deutschland GmbH, Essen, 45357, Germany|Nycomed Deutschland GmbH, Esslingen, 73734, Germany|Nycomed Deutschland GmbH, Ettlingen, 76275, Germany|Nycomed Deutschland GmbH, Eutin, 23701, Germany|Nycomed Deutschland GmbH, Falkensee, 14612, Germany|Nycomed Deutschland GmbH, Feldberger Seenlandschaft, 17258, Germany|Nycomed Deutschland GmbH, Flensburg, 24937, Germany|Nycomed Deutschland GmbH, Fl?ha, 09557, Germany|Nycomed Deutschland GmbH, Frankenthal, 67227, Germany|Nycomed Deutschland GmbH, Frankfurt am Main, 60596, Germany|Nycomed Deutschland GmbH, Frankfurt, 15230, Germany|Nycomed Deutschland GmbH, Frankfurt, 15232, Germany|Nycomed Deutschland GmbH, Frankfurt, 60389, Germany|Nycomed Deutschland GmbH, Frankfurt, 60487, Germany|Nycomed Deutschland GmbH, Frankfurt, 60528, Germany|Nycomed Deutschland GmbH, Freising, 85354, Germany|Nycomed Deutschland GmbH, Friedrichshafen, 88046, Germany|Nycomed Deutschland GmbH, Friedrichshafen, 88048, Germany|Nycomed Deutschland GmbH, Fulda, 36039, Germany|Nycomed Deutschland GmbH, Fürstenfeldbruck, 82256, Germany|Nycomed Deutschland GmbH, Fürstenwalde, 15517, Germany|Nycomed Deutschland GmbH, Fürth, 90762, Germany|Nycomed Deutschland GmbH, Fürth, 90766, Germany|Nycomed Deutschland GmbH, Ganderkesee, 27777, Germany|Nycomed Deutschland GmbH, Gardelegen, 39638, Germany|Nycomed Deutschland GmbH, Garmisch-Partenkirchen, 82467, Germany|Nycomed Deutschland GmbH, Gauting, 82131, Germany|Nycomed Deutschland GmbH, Gelsenkirchen, 45879, Germany|Nycomed Deutschland GmbH, Gelsenkirchen, 45881, Germany|Nycomed Deutschland GmbH, Gelsenkirchen, 45891, Germany|Nycomed Deutschland GmbH, Gelsenkirchen, 45894, Germany|Nycomed Deutschland GmbH, Gelsenkirchen, 45897, Germany|Nycomed Deutschland GmbH, Gemünden, 97737, Germany|Nycomed Deutschland GmbH, Germering, 82110, Germany|Nycomed Deutschland GmbH, Gifhorn, 38518, Germany|Nycomed Deutschland GmbH, Gladbeck, 45966, Germany|Nycomed Deutschland GmbH, Gladbeck, 45968, Germany|Nycomed Deutschland GmbH, Glauchau, 08371, Germany|Nycomed Deutschland GmbH, Goch, 47574, Germany|Nycomed Deutschland GmbH, Gotha, 99867, Germany|Nycomed Deutschland GmbH, Grebenstein, 34393, Germany|Nycomed Deutschland GmbH, Grefrath, 47929, Germany|Nycomed Deutschland GmbH, Greiz, 07973, Germany|Nycomed Deutschland GmbH, Grimmen, 18507, Germany|Nycomed Deutschland GmbH, Gro? Kreutz, 14550, Germany|Nycomed Deutschland GmbH, Gro?aitingen, 86845, Germany|Nycomed Deutschland GmbH, Gro?efehn, 26629, Germany|Nycomed Deutschland GmbH, Gro?korbetha, 06688, Germany|Nycomed Deutschland GmbH, Gro?schirma, 09603, Germany|Nycomed Deutschland GmbH, Gr?fenhainichen, 06773, Germany|Nycomed Deutschland GmbH, Gr?mitz, 23743, Germany|Nycomed Deutschland GmbH, Gütersloh, 33330, Germany|Nycomed Deutschland GmbH, Hagen, 58089, Germany|Nycomed Deutschland GmbH, Hagen, 58095, Germany|Nycomed Deutschland GmbH, Hagen, 58135, Germany|Nycomed Deutschland GmbH, Haibach, 63808, Germany|Nycomed Deutschland GmbH, Halberstadt, 38820, Germany|Nycomed Deutschland GmbH, Halbe, 15757, Germany|Nycomed Deutschland GmbH, Halle (Saale), 06114, Germany|Nycomed Deutschland GmbH, Halle, 06108, Germany|Nycomed Deutschland GmbH, Halle, 06110, Germany|Nycomed Deutschland GmbH, Halle, 06132, Germany|Nycomed Deutschland GmbH, Halle, 33790, Germany|Nycomed Deutschland GmbH, Halstenbek, 25469, Germany|Nycomed Deutschland GmbH, Hamburg, 20255, Germany|Nycomed Deutschland GmbH, Hamburg, 20354, Germany|Nycomed Deutschland GmbH, Hamburg, 20359, Germany|Nycomed Deutschland GmbH, Hamburg, 20537, Germany|Nycomed Deutschland GmbH, Hamburg, 21029, Germany|Nycomed Deutschland GmbH, Hamburg, 22041, Germany|Nycomed Deutschland GmbH, Hamburg, 22299, Germany|Nycomed Deutschland GmbH, Hamburg, 22527, Germany|Nycomed Deutschland GmbH, Hamburg, 22767, Germany|Nycomed Deutschland GmbH, Hammelburg, 97762, Germany|Nycomed Deutschland GmbH, Hann. Münden, 34346, Germany|Nycomed Deutschland GmbH, Hannover, 30161, Germany|Nycomed Deutschland GmbH, Hannover, 30163, Germany|Nycomed Deutschland GmbH, Hannover, 30173, Germany|Nycomed Deutschland GmbH, Hannover, 30449, Germany|Nycomed Deutschland GmbH, Hannover, 30625, Germany|Nycomed Deutschland GmbH, Haren, 49733, Germany|Nycomed Deutschland GmbH, Hartha, 04746, Germany|Nycomed Deutschland GmbH, Haselünne, 49740, Germany|Nycomed Deutschland GmbH, Ha?loch, 67454, Germany|Nycomed Deutschland GmbH, Heidelberg, 69115, Germany|Nycomed Deutschland GmbH, Heilbronn, 74072, Germany|Nycomed Deutschland GmbH, Heilbronn, 74080, Germany|Nycomed Deutschland GmbH, Heiligenhafen, 23774, Germany|Nycomed Deutschland GmbH, Heiligenhaus, 42579, Germany|Nycomed Deutschland GmbH, Heimbuchenthal, 63872, Germany|Nycomed Deutschland GmbH, Hemmingen, 30966, Germany|Nycomed Deutschland GmbH, Herbsleben, 99955, Germany|Nycomed Deutschland GmbH, Herne, 44623, Germany|Nycomed Deutschland GmbH, Herne, 44629, Germany|Nycomed Deutschland GmbH, Herne, 44649, Germany|Nycomed Deutschland GmbH, Herne, 44651, Germany|Nycomed Deutschland GmbH, Herzlake, 49770, Germany|Nycomed Deutschland GmbH, Hettstedt, 06333, Germany|Nycomed Deutschland GmbH, Hille, 32429, Germany|Nycomed Deutschland GmbH, Hohenm?lsen, 06679, Germany|Nycomed Deutschland GmbH, Homberg, 34576, Germany|Nycomed Deutschland GmbH, Homburg, 66424, Germany|Nycomed Deutschland GmbH, Horb, 72160, Germany|Nycomed Deutschland GmbH, Hoyerswerda, 02977, Germany|Nycomed Deutschland GmbH, H?chstadt, 91315, Germany|Nycomed Deutschland GmbH, Ibbenbüren, 49477, Germany|Nycomed Deutschland GmbH, Idstein, 65510, Germany|Nycomed Deutschland GmbH, Illerrieden, 89186, Germany|Nycomed Deutschland GmbH, Iserlohn, 58636, Germany|Nycomed Deutschland GmbH, Issum, 47661, Germany|Nycomed Deutschland GmbH, Itzehoe, 25524, Germany|Nycomed Deutschland GmbH, Jessen, 06917, Germany|Nycomed Deutschland GmbH, Jettingen, 71131, Germany|Nycomed Deutschland GmbH, Johannesberg, 63867, Germany|Nycomed Deutschland GmbH, Jübek, 24855, Germany|Nycomed Deutschland GmbH, Kaiserslautern, 67655, Germany|Nycomed Deutschland GmbH, Kamenz, 01917, Germany|Nycomed Deutschland GmbH, Kamen, 59174, Germany|Nycomed Deutschland GmbH, Kandern, 79400, Germany|Nycomed Deutschland GmbH, Karlsruhe, 76227, Germany|Nycomed Deutschland GmbH, Kempten, 87435, Germany|Nycomed Deutschland GmbH, Kevelaer, 47623, Germany|Nycomed Deutschland GmbH, Kirchenlamitz, 95154, Germany|Nycomed Deutschland GmbH, Kirchheim, 73230, Germany|Nycomed Deutschland GmbH, Kleinostheim, 63801, Germany|Nycomed Deutschland GmbH, Klingenberg, 63911, Germany|Nycomed Deutschland GmbH, Koblenz, 56068, Germany|Nycomed Deutschland GmbH, Koblenz, 56070, Germany|Nycomed Deutschland GmbH, Konstanz, 78462, Germany|Nycomed Deutschland GmbH, Kornwestheim, 70806, Germany|Nycomed Deutschland GmbH, Krefeld, 47803, Germany|Nycomed Deutschland GmbH, Krefeld, 47805, Germany|Nycomed Deutschland GmbH, Krumbach, 86381, Germany|Nycomed Deutschland GmbH, Krummh?rn, 26736, Germany|Nycomed Deutschland GmbH, Kyritz, 16866, Germany|Nycomed Deutschland GmbH, K?ln, 50672, Germany|Nycomed Deutschland GmbH, K?ln, 50733, Germany|Nycomed Deutschland GmbH, K?ln, 50825, Germany|Nycomed Deutschland GmbH, K?ln, 50931, Germany|Nycomed Deutschland GmbH, K?ln, 50937, Germany|Nycomed Deutschland GmbH, K?ln, 50996, Germany|Nycomed Deutschland GmbH, K?ln, 51061, Germany|Nycomed Deutschland GmbH, K?ln, 51063, Germany|Nycomed Deutschland GmbH, K?nigs Wusterhausen, 15711, Germany|Nycomed Deutschland GmbH, K?then, 06366, Germany|Nycomed Deutschland GmbH, Laage, 18299, Germany|Nycomed Deutschland GmbH, Lahr, 77933, Germany|Nycomed Deutschland GmbH, Lambrecht, 67466, Germany|Nycomed Deutschland GmbH, Landshut, 84036, Germany|Nycomed Deutschland GmbH, Langenfeld, 40764, Germany|Nycomed Deutschland GmbH, Langenhagen, 30851, Germany|Nycomed Deutschland GmbH, Langwedel, 27299, Germany|Nycomed Deutschland GmbH, Lathen, 49762, Germany|Nycomed Deutschland GmbH, Laubach, 35321, Germany|Nycomed Deutschland GmbH, Lehre, 38165, Germany|Nycomed Deutschland GmbH, Leipzig, 04103, Germany|Nycomed Deutschland GmbH, Leipzig, 04107, Germany|Nycomed Deutschland GmbH, Leipzig, 04157, Germany|Nycomed Deutschland GmbH, Leipzig, 04205, Germany|Nycomed Deutschland GmbH, Leipzig, 04207, Germany|Nycomed Deutschland GmbH, Leipzig, 04275, Germany|Nycomed Deutschland GmbH, Leipzig, 04357, Germany|Nycomed Deutschland GmbH, Lensahn, 23738, Germany|Nycomed Deutschland GmbH, Leonberg, 71229, Germany|Nycomed Deutschland GmbH, Leverkusen, 51371, Germany|Nycomed Deutschland GmbH, Leverkusen, 51373, Germany|Nycomed Deutschland GmbH, Lichtenfels, 96215, Germany|Nycomed Deutschland GmbH, Limbach-Oberfrohna, 09212, Germany|Nycomed Deutschland GmbH, Limburg, 65549, Germany|Nycomed Deutschland GmbH, Lindenfels, 64678, Germany|Nycomed Deutschland GmbH, Lippetal, 59510, Germany|Nycomed Deutschland GmbH, Lippstadt, 59555, Germany|Nycomed Deutschland GmbH, Ludwigshafen, 67063, Germany|Nycomed Deutschland GmbH, Ludwigslust, 19288, Germany|Nycomed Deutschland GmbH, Lutherstadt Wittenberg, 06886, Germany|Nycomed Deutschland GmbH, L?bau, 02708, Germany|Nycomed Deutschland GmbH, L?hne, 32584, Germany|Nycomed Deutschland GmbH, Lübeck, 23552, Germany|Nycomed Deutschland GmbH, Lübeck, 23558, Germany|Nycomed Deutschland GmbH, Lühmannsdorf, 17495, Germany|Nycomed Deutschland GmbH, Lüneburg, 21335, Germany|Nycomed Deutschland GmbH, Lützen, 06686, Germany|Nycomed Deutschland GmbH, Magdeburg, 39104, Germany|Nycomed Deutschland GmbH, Magdeburg, 39112, Germany|Nycomed Deutschland GmbH, Mainz, 55122, Germany|Nycomed Deutschland GmbH, Mannheim, 68161, Germany|Nycomed Deutschland GmbH, Mannheim, 68165, Germany|Nycomed Deutschland GmbH, Mannheim, 68309, Germany|Nycomed Deutschland GmbH, Marburg, 35037, Germany|Nycomed Deutschland GmbH, Marienhafe, 26529, Germany|Nycomed Deutschland GmbH, Marienheide, 51709, Germany|Nycomed Deutschland GmbH, Marl, 45770, Germany|Nycomed Deutschland GmbH, Meckenbeuren, 88074, Germany|Nycomed Deutschland GmbH, Meckenheim, 53340, Germany|Nycomed Deutschland GmbH, Meerbusch, 40668, Germany|Nycomed Deutschland GmbH, Meisenheim, 55590, Germany|Nycomed Deutschland GmbH, Menden, 58706, Germany|Nycomed Deutschland GmbH, Mendig, 56743, Germany|Nycomed Deutschland GmbH, Merchweiler, 66589, Germany|Nycomed Deutschland GmbH, Merseburg, 06217, Germany|Nycomed Deutschland GmbH, Mertendorf, 06618, Germany|Nycomed Deutschland GmbH, Meuselwitz, 04610, Germany|Nycomed Deutschland GmbH, Miesbach, 83714, Germany|Nycomed Deutschland GmbH, Minden, 32423, Germany|Nycomed Deutschland GmbH, Minden, 32425, Germany|Nycomed Deutschland GmbH, Moers, 47441, Germany|Nycomed Deutschland GmbH, Monheim, 40789, Germany|Nycomed Deutschland GmbH, Moormerland, 26802, Germany|Nycomed Deutschland GmbH, M?nchengladbach, 41061, Germany|Nycomed Deutschland GmbH, M?nchengladbach, 41199, Germany|Nycomed Deutschland GmbH, M?nchengladbach, 41236, Germany|Nycomed Deutschland GmbH, Mülheim, 45468, Germany|Nycomed Deutschland GmbH, München, 80336, Germany|Nycomed Deutschland GmbH, München, 80539, Germany|Nycomed Deutschland GmbH, München, 80686, Germany|Nycomed Deutschland GmbH, München, 80802, Germany|Nycomed Deutschland GmbH, München, 81241, Germany|Nycomed Deutschland GmbH, München, 81243, Germany|Nycomed Deutschland GmbH, München, 81377, Germany|Nycomed Deutschland GmbH, München, 81667, Germany|Nycomed Deutschland GmbH, München, 81677, Germany|Nycomed Deutschland GmbH, Münster, 48143, Germany|Nycomed Deutschland GmbH, Münster, 48145, Germany|Nycomed Deutschland GmbH, Münster, 48157, Germany|Nycomed Deutschland GmbH, Münzenberg, 35516, Germany|Nycomed Deutschland GmbH, Nauen, 14641, Germany|Nycomed Deutschland GmbH, Neckartailfingen, 72666, Germany|Nycomed Deutschland GmbH, Nettersheim, 53947, Germany|Nycomed Deutschland GmbH, Neuhausen, 78579, Germany|Nycomed Deutschland GmbH, Neumarkt, 92318, Germany|Nycomed Deutschland GmbH, Neunkirchen, 66538, Germany|Nycomed Deutschland GmbH, Neuss, 41460, Germany|Nycomed Deutschland GmbH, Neuss, 41466, Germany|Nycomed Deutschland GmbH, Neustadt, 07806, Germany|Nycomed Deutschland GmbH, Neustadt, 35279, Germany|Nycomed Deutschland GmbH, Neuwied, 56564, Germany|Nycomed Deutschland GmbH, Nienburg, 31582, Germany|Nycomed Deutschland GmbH, Nordstemmen, 31171, Germany|Nycomed Deutschland GmbH, Nossen, 01683, Germany|Nycomed Deutschland GmbH, Nürnberg, 90402, Germany|Nycomed Deutschland GmbH, Nürnberg, 90439, Germany|Nycomed Deutschland GmbH, Nürnberg, 90441, Germany|Nycomed Deutschland GmbH, Nürnberg, 90443, Germany|Nycomed Deutschland GmbH, Nürnberg, 90451, Germany|Nycomed Deutschland GmbH, Nürnberg, 90459, Germany|Nycomed Deutschland GmbH, Obernzenn, 91619, Germany|Nycomed Deutschland GmbH, Oberursel, 61440, Germany|Nycomed Deutschland GmbH, Oer-Erkenschwick, 45739, Germany|Nycomed Deutschland GmbH, Offenbach am Main, 63067, Germany|Nycomed Deutschland GmbH, Offenbach, 63065, Germany|Nycomed Deutschland GmbH, Offenburg, 77654, Germany|Nycomed Deutschland GmbH, Oranienburg, 16515, Germany|Nycomed Deutschland GmbH, Ornbau, 91737, Germany|Nycomed Deutschland GmbH, Oschatz, 04758, Germany|Nycomed Deutschland GmbH, Oschersleben, 39387, Germany|Nycomed Deutschland GmbH, Osnabrück, 49074, Germany|Nycomed Deutschland GmbH, Osnabrück, 49076, Germany|Nycomed Deutschland GmbH, Osterode, 37520, Germany|Nycomed Deutschland GmbH, Ostrhauderfehn, 26842, Germany|Nycomed Deutschland GmbH, Paderborn, 33100, Germany|Nycomed Deutschland GmbH, Papenburg, 26871, Germany|Nycomed Deutschland GmbH, Parchim, 19370, Germany|Nycomed Deutschland GmbH, Pforzheim, 75179, Germany|Nycomed Deutschland GmbH, Pinneberg, 25421, Germany|Nycomed Deutschland GmbH, Pirmasens, 66955, Germany|Nycomed Deutschland GmbH, Plauen, 08523, Germany|Nycomed Deutschland GmbH, Plauen, 08525, Germany|Nycomed Deutschland GmbH, Potsdam, 14467, Germany|Nycomed Deutschland GmbH, Potsdam, 14478, Germany|Nycomed Deutschland GmbH, Potsdam, 14480, Germany|Nycomed Deutschland GmbH, Pottenstein, 91278, Germany|Nycomed Deutschland GmbH, Radebeul, 01445, Germany|Nycomed Deutschland GmbH, Radevormwald, 42477, Germany|Nycomed Deutschland GmbH, Rain, 86641, Germany|Nycomed Deutschland GmbH, Rathenow, 14712, Germany|Nycomed Deutschland GmbH, Ratingen, 40878, Germany|Nycomed Deutschland GmbH, Raubach, 56316, Germany|Nycomed Deutschland GmbH, Recke, 49509, Germany|Nycomed Deutschland GmbH, Recklinghausen, 45657, Germany|Nycomed Deutschland GmbH, Regensburg, 93055, Germany|Nycomed Deutschland GmbH, Reichenbach, 08468, Germany|Nycomed Deutschland GmbH, Reichenschwand, 91244, Germany|Nycomed Deutschland GmbH, Remscheid, 42853, Germany|Nycomed Deutschland GmbH, Remse, 08373, Germany|Nycomed Deutschland GmbH, Rendsburg, 24768, Germany|Nycomed Deutschland GmbH, Rheine, 48431, Germany|Nycomed Deutschland GmbH, Rhinow, 14728, Germany|Nycomed Deutschland GmbH, Riesa, 01591, Germany|Nycomed Deutschland GmbH, Rieschweiler-Mühlbach, 66509, Germany|Nycomed Deutschland GmbH, Rodenbach, 63517, Germany|Nycomed Deutschland GmbH, Rodenbach, 67688, Germany|Nycomed Deutschland GmbH, Roetgen, 52159, Germany|Nycomed Deutschland GmbH, Roggenburg, 89297, Germany|Nycomed Deutschland GmbH, Rosenfeld, 72348, Germany|Nycomed Deutschland GmbH, Rosengarten, 21224, Germany|Nycomed Deutschland GmbH, Rostock, 18055, Germany|Nycomed Deutschland GmbH, Rostock, 18059, Germany|Nycomed Deutschland GmbH, Rostock, 18109, Germany|Nycomed Deutschland GmbH, Roth, 91154, Germany|Nycomed Deutschland GmbH, Rottach-Egern, 83700, Germany|Nycomed Deutschland GmbH, Rudolstadt, 07407, Germany|Nycomed Deutschland GmbH, R?dermark, 63322, Germany|Nycomed Deutschland GmbH, Rüsselsheim, 65428, Germany|Nycomed Deutschland GmbH, Saalfeld/Saale, 07318, Germany|Nycomed Deutschland GmbH, Saal, 18317, Germany|Nycomed Deutschland GmbH, Saarbrücken, 66111, Germany|Nycomed Deutschland GmbH, Saarlouis, 66740, Germany|Nycomed Deutschland GmbH, Sachsenheim, 74343, Germany|Nycomed Deutschland GmbH, Salzmünde, 06198, Germany|Nycomed Deutschland GmbH, Schieder-Schwalenberg, 32816, Germany|Nycomed Deutschland GmbH, Schlo? Holte-Stukenbrock, 33758, Germany|Nycomed Deutschland GmbH, Schlüchtern, 36381, Germany|Nycomed Deutschland GmbH, Schm?lln, 04626, Germany|Nycomed Deutschland GmbH, Schrobenhausen, 86529, Germany|Nycomed Deutschland GmbH, Schwalbach, 66773, Germany|Nycomed Deutschland GmbH, Schwalmstadt, 34613, Germany|Nycomed Deutschland GmbH, Schwanewede, 28790, Germany|Nycomed Deutschland GmbH, Schwedt, 16303, Germany|Nycomed Deutschland GmbH, Schweinfurt, 97421, Germany|Nycomed Deutschland GmbH, Schwerin, 19053, Germany|Nycomed Deutschland GmbH, Schwerin, 19057, Germany|Nycomed Deutschland GmbH, Schwetzingen, 68723, Germany|Nycomed Deutschland GmbH, Schw?bisch Gmünd, 73525, Germany|Nycomed Deutschland GmbH, Sch?nberg, 24217, Germany|Nycomed Deutschland GmbH, Sch?nebeck, 39218, Germany|Nycomed Deutschland GmbH, Sebnitz, 01855, Germany|Nycomed Deutschland GmbH, Seelow, 15306, Germany|Nycomed Deutschland GmbH, Seevetal, 21217, Germany|Nycomed Deutschland GmbH, Seewald, 72297, Germany|Nycomed Deutschland GmbH, Sendenhorst, 48324, Germany|Nycomed Deutschland GmbH, Sickte, 38173, Germany|Nycomed Deutschland GmbH, Siegen, 57072, Germany|Nycomed Deutschland GmbH, Simmern, 55469, Germany|Nycomed Deutschland GmbH, Simmertal, 55618, Germany|Nycomed Deutschland GmbH, Sinntal, 36391, Germany|Nycomed Deutschland GmbH, Sinsheim, 74889, Germany|Nycomed Deutschland GmbH, Solingen, 42651, Germany|Nycomed Deutschland GmbH, Solingen, 42655, Germany|Nycomed Deutschland GmbH, Solingen, 42657, Germany|Nycomed Deutschland GmbH, Solingen, 42697, Germany|Nycomed Deutschland GmbH, Solingen, 42699, Germany|Nycomed Deutschland GmbH, Soltau, 29614, Germany|Nycomed Deutschland GmbH, Sonneberg, 96515, Germany|Nycomed Deutschland GmbH, Speyer, 67346, Germany|Nycomed Deutschland GmbH, Sprockh?vel, 45549, Germany|Nycomed Deutschland GmbH, St. Blasien, 79837, Germany|Nycomed Deutschland GmbH, Stadtallendorf, 35260, Germany|Nycomed Deutschland GmbH, Stadthagen, 31655, Germany|Nycomed Deutschland GmbH, Staig, 89195, Germany|Nycomed Deutschland GmbH, Steimel, 57614, Germany|Nycomed Deutschland GmbH, Steinbach, 61449, Germany|Nycomed Deutschland GmbH, Steinfeld, 49439, Germany|Nycomed Deutschland GmbH, Steinhagen, 33803, Germany|Nycomed Deutschland GmbH, Stockach, 78333, Germany|Nycomed Deutschland GmbH, Straelen, 47638, Germany|Nycomed Deutschland GmbH, Stralsund, 18437, Germany|Nycomed Deutschland GmbH, Straupitz, 15913, Germany|Nycomed Deutschland GmbH, Strausberg, 15344, Germany|Nycomed Deutschland GmbH, Stuhr, 28816, Germany|Nycomed Deutschland GmbH, Stuttgart, 70173, Germany|Nycomed Deutschland GmbH, Stuttgart, 70191, Germany|Nycomed Deutschland GmbH, Stuttgart, 70372, Germany|Nycomed Deutschland GmbH, Stuttgart, 70435, Germany|Nycomed Deutschland GmbH, Stuttgart, 70565, Germany|Nycomed Deutschland GmbH, Sulz, 72172, Germany|Nycomed Deutschland GmbH, Sundern, 59846, Germany|Nycomed Deutschland GmbH, S?mmerda, 99610, Germany|Nycomed Deutschland GmbH, Sü?en, 73079, Germany|Nycomed Deutschland GmbH, Tangermünde, 39590, Germany|Nycomed Deutschland GmbH, Teltow, 14513, Germany|Nycomed Deutschland GmbH, Teterow, 17166, Germany|Nycomed Deutschland GmbH, Teuchern, 06682, Germany|Nycomed Deutschland GmbH, Teutschenthal, 06179, Germany|Nycomed Deutschland GmbH, Thurnau, 95349, Germany|Nycomed Deutschland GmbH, Tirschenreuth, 95643, Germany|Nycomed Deutschland GmbH, Tuttlingen, 78532, Germany|Nycomed Deutschland GmbH, Uchte, 31600, Germany|Nycomed Deutschland GmbH, Ueckermünde, 17373, Germany|Nycomed Deutschland GmbH, Ulm, 89073, Germany|Nycomed Deutschland GmbH, Unna, 59423, Germany|Nycomed Deutschland GmbH, Urbach, 56317, Germany|Nycomed Deutschland GmbH, Uttenreuth, 91080, Germany|Nycomed Deutschland GmbH, Vaihingen, 71665, Germany|Nycomed Deutschland GmbH, Viersen, 41751, Germany|Nycomed Deutschland GmbH, Villingen-Schwenningen, 78050, Germany|Nycomed Deutschland GmbH, Vilshofen, 94474, Germany|Nycomed Deutschland GmbH, Voerde, 46562, Germany|Nycomed Deutschland GmbH, Waiblingen, 71332, Germany|Nycomed Deutschland GmbH, Wandlitz, 16348, Germany|Nycomed Deutschland GmbH, Waren (Müritz), 17192, Germany|Nycomed Deutschland GmbH, Weidenberg, 95446, Germany|Nycomed Deutschland GmbH, Weilheim, 82362, Germany|Nycomed Deutschland GmbH, Wei?enfels, 06667, Germany|Nycomed Deutschland GmbH, Wei?wasser, 02943, Germany|Nycomed Deutschland GmbH, Werder, 14542, Germany|Nycomed Deutschland GmbH, Wetter, 35083, Germany|Nycomed Deutschland GmbH, Wiesbaden, 65183, Germany|Nycomed Deutschland GmbH, Wiesloch, 69168, Germany|Nycomed Deutschland GmbH, Wilhermsdorf, 91452, Germany|Nycomed Deutschland GmbH, Wilster, 25554, Germany|Nycomed Deutschland GmbH, Winh?ring, 84543, Germany|Nycomed Deutschland GmbH, Wissen, 57537, Germany|Nycomed Deutschland GmbH, Witten, 58452, Germany|Nycomed Deutschland GmbH, Wittislingen, 89426, Germany|Nycomed Deutschland GmbH, Wittstock, 16909, Germany|Nycomed Deutschland GmbH, Wolfsburg, 38440, Germany|Nycomed Deutschland GmbH, Wolfsburg, 38446, Germany|Nycomed Deutschland GmbH, Wolfschlugen, 72649, Germany|Nycomed Deutschland GmbH, Wolgast, 17438, Germany|Nycomed Deutschland GmbH, Wulfen, 06369, Germany|Nycomed Deutschland GmbH, Wyhl, 79369, Germany|Nycomed Deutschland GmbH, W?llstein, 55597, Germany|Nycomed Deutschland GmbH, W?rth, 76744, Germany|Nycomed Deutschland GmbH, Würzburg, 97070, Germany|Nycomed Deutschland GmbH, Xanten, 46509, Germany|Nycomed Deutschland GmbH, Zeitz, 06712, Germany|Nycomed Deutschland GmbH, Zellingen, 97225, Germany|Nycomed Deutschland GmbH, Zerbst, 39261, Germany|Nycomed Deutschland GmbH, Zossen, 15806, Germany|Nycomed Deutschland GmbH, Zwickau, 08066, Germany|Nycomed Deutschland GmbH, Zühlsdorf, 16515, Germany|Nycomed Deutschland GmbH, überlingen, 88662, Germany Less << | |
NCT00246922 | Bronchial Asthma | PHASE3 | COMPLETED | 2025-10-07 | Nycomed Japan and Mitsubishi T... More >>anabe Pharma Corporation, Osaka, Japan Less << |
NCT00062582 | Chronic Obstructive Pulmonary ... More >>Disease|COPD Less << | PHASE3 | COMPLETED | - | ALTANA Pharma, Cities in Alaba... More >>ma, Alabama, United States|ALTANA Pharma, Cities in Arizona, Arizona, United States|ALTANA Pharma, Cities in California, California, United States|ATLANA Pharma, Cities in Colorado, Colorado, United States|ALTANA Pharma, Cities in Conneticut, Connecticut, United States|ALTANA Pharma, Cities in Delaware, Delaware, United States|ALTANA Pharma, Cities in Florida, Florida, United States|ALTANA Pharma, Cities in Georgia, Georgia, United States|ALTANA Pharma, Cities in Idaho, Idaho, United States|ALTANA Pharma, Cities in Indiana, Indiana, United States|ALTANA Pharma, Cities in Iowa, Iowa, United States|ALTANA Pharma, Cities in Kansas, Kansas, United States|ALTANA Pharma, Cities in Kentucky, Kentucky, United States|ALTANA Pharma, Cities in Louisiana, Louisiana, United States|ALTANA Pharma, Cities in Maryland, Maryland, United States|ALTANA Pharma, Cities in Michigan, Michigan, United States|ALTANA Pharma, Cities in Missouri, Missouri, United States|ALTANA Pharma, Cities in Nebraska, Nebraska, United States|ALTANA Pharma, Cities in Nevada, Nevada, United States|ALTANA Pharma, Cities in New Jersey, New Jersey, United States|ALTANA Pharma, Cities in New York, New York, United States|ALTANA Pharma, Cities in North Carolina, North Carolina, United States|ALTANA Pharma, Cities in Ohio, Ohio, United States|ALTANA Pharma, Cities in Oregon, Oregon, United States|ALTANA Pharma, Cities in Pennsylvania, Pennsylvania, United States|ALTANA Pharma, Cities in Rhode Island, Rhode Island, United States|ALTANA Pharma, Cities in South Carolina, South Carolina, United States|ALTANA Pharma, Cities in Texas, Texas, United States|ALTANA Pharma, Cities in Utah, Utah, United States|ALTANA Pharma, Cities in Virginia, Virginia, United States|ALTANA Pharma, Cities in Washington, Washington, United States|ALTANA Pharma, Cities in West Virginia, West Virginia, United States|ALTANA Pharma, Cities in Argentina, Argentina|ALTANA Pharma, Cities in Canada, Canada|ALTANA Pharma, Cities in Colombia, Colombia|ALTANA Pharma, Cities in Mexico, Mexico|ALTANA Pharma, Cities in Peru, Peru Less << |
NCT00246935 | Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << | PHASE3 | COMPLETED | 2025-10-07 | Nycomed in Japan and Mitsubish... More >>i Tanabe Pharma Corporation, Osaka, Japan Less << |
NCT02187926 | - | Completed | - | - | |
NCT00242307 | Bronchial Asthma | PHASE2|PHASE3 | COMPLETED | 2025-06-07 | Nycomed Japan and Mitsubishi T... More >>anabe Pharma Corporation, Osaka, Japan Less << |
NCT00073177 | Asthma | PHASE3 | COMPLETED | - | ALTANA Pharma, Cities in Alaba... More >>ma, Alabama, United States|ALTANA Pharma, Cities in Arizona, Arizona, United States|ALTANA Pharma, Cities in Arkansas, Arkansas, United States|ALTANA Pharma, Cities in California, California, United States|ALTANA Pharma, Cities in Colorado, Colorado, United States|ALTANA Pharma, Cities in Florida, Florida, United States|ALTANA Pharma, Cities in Georgia, Georgia, United States|ALTANA Pharma, Cities in Idaho, Idaho, United States|ALTANA Pharma, Cities in Illinois, Illinois, United States|ALTANA Pharma, Cities in Indiana, Indiana, United States|ALTANA Pharma, Cities in Iowa, Iowa, United States|ALTANA Pharma, Cities in Kansas, Kansas, United States|ALTANA Pharma, Cities in Kentucky, Kentucky, United States|ALTANA Pharma, Cities in Louisiana, Louisiana, United States|ALTANA Pharma, Cities in Maryland, Maryland, United States|ALTANA Pharma, Massachusetts, Massachusetts, United States|ALTANA Pharma, Cities in Michigan, Michigan, United States|ALTANA Pharma, Cities in Minnesota, Minnesota, United States|ALTANA Pharma, Cities in Mississippi, Mississippi, United States|ALTANA Pharma, Cities in Missouri, Missouri, United States|ALTANA Pharma, Cities in Montana, Montana, United States|ALTANA Pharma, Cities in Nebraska, Nebraska, United States|ALTANA Pharma, Cities in Nevada, Nevada, United States|ALTANA Pharma, Cities in New Jersey, New Jersey, United States|ALTANA Pharma, Cities in New York, New York, United States|ALTANA Pharma, Cities in North Carolina, North Carolina, United States|ALTANA Pharma, Cities in North Dakota, North Dakota, United States|ALTANA Pharma, Cities in Oregon, Oregon, United States|ALTANA Pharma, Cities in Pennsylvania, Pennsylvania, United States|ALTANA Pharma, Cities in Rhode Island, Rhode Island, United States|ALTANA Pharma, Cities in South Carolina, South Carolina, United States|ALTANA Pharma, Cities in Tennessee, Tennessee, United States|ALTANA Pharma, Cities in Texas, Texas, United States|ALTANA Pharma, Cities in Utah, Utah, United States|ALTANA Pharma, Cities in Virginia, Virginia, United States|ALTANA Pharma, Cities in Washington, Washington, United States|ALTANA Pharma, Cities in Wisconsin, Wisconsin, United States|ALTANA Pharma, Cities in Argentina, Argentina|ALTANA Pharma, Cities in Colombia, Colombia|ALTANA Pharma, Cities in Mexico, Mexico|ALTANA Pharma, Cities in Peru, Peru Less << |
NCT00076076 | Asthma | PHASE3 | COMPLETED | 2025-06-05 | ALTANA Pharma, Cities in Alaba... More >>ma, Alabama, United States|ALTANA Pharma, Cities in Arizona, Arizona, United States|ALTANA Pharma, Cities in Arkansas, Arkansas, United States|ALTANA Pharma, Cities in California, California, United States|ALTANA Pharma, Cities in Colorado, Colorado, United States|ALTANA Pharma, Cities in Connecticut, Connecticut, United States|ALTANA Pharma, Cities in Delaware, Delaware, United States|ALTANA Pharma, Cities in Florida, Florida, United States|ALTANA Pharma, Cities in Georgia, Georgia, United States|ALTANA Pharma, Cities in Illinois, Illinois, United States|ALTANA Pharma, Cities in Indiana, Indiana, United States|ALTANA Pharma, Cities in Kansas, Kansas, United States|ALTANA Pharma, Cities in Kentucky, Kentucky, United States|ALTANA Pharma, Cities in Louisiana, Louisiana, United States|ALTANA Pharma, Cities in Maine, Maine, United States|ALTANA Pharma, Cities in Maryland, Maryland, United States|ALTANA Pharma, Cities in Massachusetts, Massachusetts, United States|ALTANA Pharma, Cities in Michigan, Michigan, United States|ALTANA Pharma, Cities in Minnesota, Minnesota, United States|ALTANA Pharma, Cities in Missouri, Missouri, United States|ALTANA Pharma, Cities in Montana, Montana, United States|ALTANA Pharma, Cities in Nebraska, Nebraska, United States|ALTANA Pharma, Cities in Nevada, Nevada, United States|ALTANA Pharma, Cities in New Jersey, New Jersey, United States|ALTANA Pharma, Cities in New York, New York, United States|ALTANA Pharma, Cities in North Carolina, North Carolina, United States|ALTANA Pharma, Cities in Ohio, Ohio, United States|ALTANA Pharma, Cities in Oklahoma, Oklahoma, United States|ALTANA Pharma, Cities in Oregon, Oregon, United States|ALTANA Pharma, Cities in Pennsylvania, Pennsylvania, United States|ALTANA Pharma, Cities in Rhode Island, Rhode Island, United States|ALTANA Pharma, Cities in South Carolina, South Carolina, United States|ALTANA Pharma, Cities in Tennessee, Tennessee, United States|ALTANA Pharma, Cities in Texas, Texas, United States|ALTANA Pharma, Cities in Utah, Utah, United States|ALTANA Pharma, Cities in Vermont, Vermont, United States|ALTANA Pharma, Cities in Virginia, Virginia, United States|ALTANA Pharma, Cities in Washington, Washington, United States|ALTANA Pharma, Cities in West Virginia, West Virginia, United States|ALTANA Pharma, Cities in Russia, Russian Federation|ALTANA Pharma, Cities in the Ukraine, Ukraine Less << |
NCT00076089 | Chronic Obstructive Pulmonary ... More >>Disease|COPD Less << | PHASE3 | COMPLETED | 2025-12-05 | ALTANA Pharma, Cities in Alaba... More >>ma, Alabama, United States|ALTANA Pharma, Cities in Arizona, Arizona, United States|ALTANA Pharma, Cities in Arkansas, Arkansas, United States|ALTANA Pharma, Cities in California, California, United States|ALTANA Pharma, Cities in Colorado, Colorado, United States|ALTANA Pharma, Cities in Connecticut, Connecticut, United States|ALTANA Pharma, Cities in Florida, Florida, United States|ALTANA Pharma, Cities in Georgia, Georgia, United States|ALTANA Pharma, Cities in Illionois, Illinois, United States|ALTANA Pharma, Cities in Iowa, Iowa, United States|ALTANA Pharma, Cities in Kentucky, Kentucky, United States|ALTANA Pharma, Cities in Louisiana, Louisiana, United States|ALTANA Pharma, Cities in Massachusetts, Massachusetts, United States|ALTANA Pharma, Cities in Minnesota, Minnesota, United States|ALTANA Pharma, Cities in Missouri, Missouri, United States|ALTANA Pharma, Cities in Montana, Montana, United States|ALTANA Pharma, Cities in Nebraska, Nebraska, United States|ALTANA Pharma, Cities in Nevada, Nevada, United States|ALTANA Pharma, Cities in New Hampshire, New Hampshire, United States|ALTANA Pharma, Cities in New Jersey, New Jersey, United States|ALTANA Pharma, Cities in New York, New York, United States|ALTANA Pharma, Cities in North Carolina, North Carolina, United States|ALTANA Pharma, Cities in Ohio, Ohio, United States|ALTANA Pharma, Cities in Oklahoma, Oklahoma, United States|ALTANA Pharma, Cities in Oregon, Oregon, United States|ALTANA Pharma, Cities in Pennsylvania, Pennsylvania, United States|ALTANA Pharma, Cities in Rhode Island, Rhode Island, United States|ALTANA Pharma, Cities in South Carolina, South Carolina, United States|ALTANA Pharma, Cities in Tennessee, Tennessee, United States|ALTANA Pharma, Cities in Texas, Texas, United States|ALTANA Pharma, Cities in Utah, Utah, United States|ALTANA Pharma, Cities in Vermont, Vermont, United States|ALTANA Pharma, Cities in Virginia, Virginia, United States|ALTANA Pharma, Cities in West Virginia, West Virginia, United States|ALTANA Pharma, Cities in Wisconsin, Wisconsin, United States|ALTANA Pharma, Cities in Canada, Canada|ALTANA Pharma, Cities in France, France|ALTANA Pharma, Cities in Germany, Germany|ALTANA Pharma, Cities in Poland, Poland|ALTANA Pharma, Cities in South Africa, South Africa Less << |
NCT02051335 | Memory Impairment ... More >> Alzheimer's Disease Less << | Phase 1 | Completed | - | United Kingdom ... More >> London, United Kingdom Less << |
NCT00163475 | Asthma | PHASE3 | COMPLETED | 2025-08-05 | ALTANA Pharma, Cities in Austr... More >>alia, Australia|ALTANA Pharma, Cities in Belgium, Belgium|ALTANA Pharma, Cities in France, France|ALTANA Pharma, Cities in South Africa, South Africa|ALTANA Pharma, Cities in Spain, Spain Less << |
NCT02671942 | Chronic Obstructive Pulmonary ... More >>Disease Less << | Phase 2 | Recruiting | December 2017 | China, Guangdong ... More >> First Affiliated Hospital of Guangzhou Medical University Recruiting Guangzhou, Guangdong, China, 510120 Contact: Zheng jinping ?? 18928868238 ?? 18928868238@163.com Less << |
NCT00163527 | Asthma | PHASE3 | COMPLETED | 2025-11-05 | ALTANA Pharma, Cities in Georg... More >>ia, Georgia, United States|ALTANA Pharma, Cities in Austria, Austria|ALTANA Pharma, Cities in Croatia, Croatia|ALTANA Pharma, Cities in the Czech Repulik, Czech Republic|ALTANA Pharma, Cities in Finland, Finland|ALTANA Pharma, Cities in France, France|ALTANA Pharma, Cities in Greece, Greece|ALTANA Pharma, Cities in Hungary, Hungary|ALTANA Pharma, Cities in India, India|ALTANA Pharma, Cities in Ireland, Ireland|ALTANA Pharma, Cities in Italy, Italy|ALTANA Pharma, Cities in New Zealand, New Zealand|ALTANA Pharma, Cities in Norway, Norway|ALTANA Pharma, Cities in Pakistan, Pakistan|ALTANA Pharma, Cities in the Philippines, Philippines|ALTANA Pharma, Cities in Poland, Poland|ALTANA Pharma, Cities in Portugal, Portugal|ALTANA Pharma, Cities in the Russian Federation, Russian Federation|ALTANA Pharma, Sites in Singapore, Singapore|ALTANA Pharma, Cities in South Africa, South Africa|ALTANA Pharma, Cities in Spain, Spain|ALTANA Pharma, Cities in Taiwan, Taiwan|ALTANA Pharma, Cities in Thailand, Thailand|ALTANA Pharma, Cities in the United Kindom, United Kingdom Less << |
NCT00297102 | Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << | Phase 3 | Completed | - | - |
NCT00297115 | - | Completed | - | - | |
NCT02015767 | - | Completed | - | - | |
NCT00940329 | Healthy | Phase 1 | Completed | - | Germany ... More >> Nycomed Konstanz, Germany, 78467 Less << |
NCT00297102 | - | Completed | - | - | |
NCT00297115 | Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << | Phase 3 | Completed | - | - |
NCT01509677 | COPD Chronic ... More >>Obstructive Pulmonary Disease Less << | Phase 3 | Completed | - | Denmark ... More >> Kobenhavn NV, Denmark K?benhavn NV, Denmark, DK-2400 Germany Freiburg, Germany Grosshansdorf, Germany Hannover, Germany Heidelberg, Germany Immenhausen, Germany Kiel, Germany Mainz, Germany Poland Bialystok, Poland Krakow, Poland Lodz, Poland, 90-153 Lodz, Poland Sweden Lund, Sweden United Kingdom Cottingham, United Kingdom Dafen, United Kingdom Leicester, United Kingdom London, United Kingdom Manchester, United Kingdom Norwich, United Kingdom, NR4 7UY Less << |
NCT01664624 | - | Completed | - | - | |
NCT00242320 | COPD | Phase 3 | Completed | - | Hong Kong ... More >> Altana Pharma/Nycomed Hong Kong, Hong Kong, 852 Altana Pharma/Nycomed Shatin, NT, Hong Kong, Hong Kong Korea, Republic of Altana Pharma/Nycomed Anvang-Si, Gveonggi-Do, Korea, Republic of, 431-070 Altana Pharma/Nycomed Chungbuk, Korea, Republic of, 361-711 Altana Pharma/Nycomed Gangwon-do, Korea, Republic of, 220-701 Altana Pharma/Nycomed Gangwon-Do, Korea, Republic of, 220-711 Altana Pharma/Nycomed Gwangju, Korea, Republic of, 501-757 Altana Pharma/Nycomed Gyeonggi-do, Korea, Republic of, 420-767 Altana Pharma/Nycomed Jiniu-Si. Gveongsangnam-Do, Korea, Republic of, 660-702 Altana Pharma/Nycomed Seoul, Korea, Republic of, 135-720 Altana Pharma/Nycomed Seoul, Korea, Republic of, 136-705 Altana Pharma/Nycomed Seoul, Korea, Republic of, 137-701 Altana Pharma/Nycomed Seoul, Korea, Republic of, 138-736 Altana Pharma/Nycomed Seoul, Korea, Republic of, 140-757 Altana Pharma/Nycomed Seoul, Korea, Republic of, 158-710 Altana Pharma/Nycomed Uijongbu-city, Gveonggi-Do, Korea, Republic of, 480-130 Altana Pharma/Nycomed Ulsan, Korea, Republic of, 682-060 Malaysia Altana Pharma/Nycomed Jalan Rasah, Seremban, Malaysia, 70300 Altana Pharma/Nycomed Kota Bharu / Kelantan, Malaysia, 16150 Altana Pharma/Nycomed Kota Kinabalu, Sabah, Malaysia, 88586 Altana Pharma/Nycomed Kuala Lumpur, Malaysia, 50590 Altana Pharma/Nycomed Kuala Lumpur, Malaysia, 56000 Altana Pharma/Nycomed Kuala Lumpur, Malaysia, 59100 Philippines Altana Pharma/Nycomed Manila, Philippines, 1000 Altana Pharma/Nycomed Quezon City, Philippines, 1100 Altana Pharma/Nycomed Quezon City, Philippines, 1102 Altana Pharma/Nycomed Quezon City, Philippines, 850 Altana Pharma/Nycomed Quezon City, Philippines, 870 Taiwan Altana Pharma/Nycomed Kaohsiung, Taiwan, 886-807 Altana Pharma/Nycomed Taipei City 114, Taiwan, 886-114 Altana Pharma/Nycomed Taipei, Taiwan, 886-114 Altana Pharma/Nycomed Taipei, Taiwan Altana Pharma/Nycomed Tau-Yuan, Taiwan, 886-333 Less << |
NCT00313209 | Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << | Phase 3 | Completed | - | - |
NCT00430729 | Chronic Obstructive Pulmonary ... More >>Disease|COPD Less << | PHASE3 | COMPLETED | - | ALTANA Pharma, Cities in Austr... More >>alia, Australia|ALTANA Pharma, Cities in Austria, Austria|ALTANA Pharma, Cities in Canada, Canada|ALTANA Pharma, Cities in France, France|ALTANA Pharma, Cities in Hungary, Hungary|ALTANA Pharma, Cities in Italy, Italy|ALTANA Pharma, Cities in the Netherlands, Netherlands|ALTANA Pharma, Cities in Poland, Poland|ALTANA Pharma, Cities in Portugal, Portugal|ALTANA Pharma, Cities in the Russian Federation, Russian Federation|ALTANA Pharma, Cities in South Africa, South Africa|ALTANA Pharma, Cities in Spain, Spain|ALTANA Pharma, Cities in Switzerland, Switzerland|ALTANA Pharma, Cities in the United Kingdom, United Kingdom Less << |
NCT02051335 | - | Completed | - | - | |
NCT00746434 | Plaque Psoriasis | Phase 2 | Withdrawn(Study withdrawn due ... More >>to business decisions. No subjects were treated.) Less << | September 2009 | - |
NCT01473758 | Chronic Obstructive Pulmonary ... More >>Disease With (Acute) Exacerbation Less << | Phase 2 | Terminated(Company decision No... More >> Safety or Efficacy Concerns) Less << | - | United Kingdom ... More >> Academic Unit of Respiratory Medicine, Royal Free Hospital, Jadwiga A. Wedzicha London, United Kingdom, NW3 2PF London, United Kingdom Less << |
NCT00313209 | - | Completed | - | - | |
NCT01433666 | Dementia | Phase 2 | Completed | - | Netherlands ... More >> Maastricht University, Faculty of Psychology and Neuroscience Maastricht, Limburg, Netherlands, 6200 MD Less << |
NCT01313494 | COPD | Phase 3 | Completed | - | China ... More >> Beijing, China Changsha, China Chengdu, China Chongqing, China Fuzhou, China Guangzhou, China Hangzhou, China Nanjing, China Nanning, China Qingdao, China Shanghai, China Shenyang, China Shijiazhuang, China Hong Kong Hong Kong, Hong Kong Singapore Singapore, Singapore Less << |
NCT01140542 | Diabetes Mellitus Type 2 | PHASE2 | COMPLETED | 2025-03-08 | - |
NCT01480661 | Pulmonary Disease, Chronic Obs... More >>tructive Less << | Phase 4 | Completed | - | Belgium ... More >> Antwerp University Hospital Edegem, Antwerp, Belgium, 2650 ZNA Middelheim Antwerp, Belgium, 2020 Less << |
NCT00424268 | Chronic Obstructive Pulmonary ... More >>Disease Less << | Phase 3 | Completed | - | - |
NCT01473758 | - | Terminated(Company decision No... More >> Safety or Efficacy Concerns) Less << | - | - | |
NCT01329029 | Chronic Obstructive Pulmonary ... More >>Disease Less << | Phase 4 | Completed | - | - |
NCT01664624 | Type 2 Diabetes | Phase 1 | Completed | - | United States, California ... More >> Chula Vista, California, United States United States, Florida Orlando, Florida, United States Less << |
NCT00746382 | Dermatitis | Phase 2 | Withdrawn(Study withdrawn due ... More >>to business decisions. No subjects were treated.) Less << | September 2009 | - |
NCT01703260 | Nonalcoholic Steatohapatitis | Phase 2 | Terminated(Company decision; N... More >>o safety or efficacy concerns (see detailed description)) Less << | - | United States, California ... More >> Coronado, California, United States, 92118 Coronado, California, United States United States, Maryland Annapolis, Maryland, United States, 21401 Baltimore, Maryland, United States, 21202 Less << |
NCT01595750 | Chronic Obstructive Pulmonary ... More >>Disease Less << | Phase 4 | Unknown | August 2012 | Spain ... More >> Spanish Research Center for Respiratory Diseases Not yet recruiting Bunyola, Balearic Island, Spain, 07110 Contact: Paloma Vaquer ?? 0034971011772 ?? pvaquer@ciberes.org Less << |
NCT01329029 | - | Completed | - | - | |
NCT00424268 | - | Completed | - | - | |
NCT01856764 | - | Completed | - | - | |
NCT02187250 | PCOS Obesity | Phase 4 | Completed | - | Slovenia ... More >> University Medical Center Ljubljana Ljubljana, Slovenia, 1000 Less << |
NCT01313494 | - | Completed | - | - | |
NCT01856764 | Atopic Dermatitis | Phase 2 | Completed | - | Germany ... More >> Berlin, Germany Gera, Germany Hamburg, Germany Less << |
NCT01701934 | Chronic Obstructive Pulmonary ... More >>Disease Metabolic Syndrome Less << | Phase 2 | Terminated(The recruitment of ... More >>the study was prematurely stopped in July 2014 for the following reason; no more study medication.) Less << | December 2014 | Canada, British Columbia ... More >> St. Paul's Hospital Vancouver, British Columbia, Canada, V6Z 1Y6 Canada, Quebec Centre hospitalier de l'Université de Montréal Montréal, Quebec, Canada, H2W 1T8 Montreal Chest Institute Montréal, Quebec, Canada, H2X 2P4 Institut universitaire de cardiologie et de pneumologie de Québec Québec, Quebec, Canada, G1V 4G5 H?pital régional de Saint-Jér?me Saint-Jér?me, Quebec, Canada, J7Z 5T3 Less << |
NCT01572948 | COPD | Not Applicable | Completed | - | United States, Alabama ... More >> UAB Lung Health Center Birmingham, Alabama, United States, 35294 Less << |
NCT01703260 | - | Terminated(Company decision; N... More >>o safety or efficacy concerns (see detailed description)) Less << | - | - | |
NCT01888952 | Advanced B-cell Lymphoid Malig... More >>nancies Less << | Early Phase 1 | Completed | - | United States, Texas ... More >> Ctrc @ Uthscsa San Antonio, Texas, United States, 78229 Less << |
NCT01572948 | - | Completed | - | - | |
NCT01888952 | - | Completed | - | - | |
NCT01973998 | COPD | Phase 3 | Completed | - | United States, Pennsylvania ... More >> Temple University Hospital Philadelphia, Pennsylvania, United States, 19140 Less << |
NCT02097992 | - | Completed | - | - | |
NCT02079844 | Schizophrenia | Phase 1 | Completed | - | United Kingdom ... More >> Denmark Hill, London, United Kingdom Less << |
NCT02037672 | PCOS Obesity | Phase 4 | Completed | - | Slovenia ... More >> University Medical Center Ljubljana Ljubljana, Slovenia, 1000 Less << |
NCT01443845 | COPD COPD Exa... More >>cerbation Lung Diseases Respiratory Disorders Pulmonary Disease Chronic Obstructive Lung Diseases Chronic Obstructive Airway Disease Less << | Phase 4 | Completed | - | - |
NCT01765192 | Asthma | Phase 2 | Completed | - | Germany ... More >> Berlin, Germany Grosshansdorf, Germany Hamburg, Germany Hannover, Germany Mainz, Germany Schwerin, Germany Hungary Budapest, Hungary Nyiregyhaza, Hungary Szarvas, Hungary Torokbalint, Hungary South Africa Bloemfontein, South Africa Cape Town, South Africa Pretoria, South Africa Less << |
NCT03073798 | - | Completed | - | - | |
NCT01765192 | - | Completed | - | - | |
NCT02079844 | - | Completed | - | - | |
NCT02451540 | Pulmonary Disease, Chronic Obs... More >>tructive Less << | Phase 2 | Terminated(No new investigatio... More >>nal product can be delivered to the site.) Less << | - | Belgium ... More >> University Hospital of Antwerp Edegem, Antwerp, Belgium, 2650 Less << |
NCT01630200 | Chronic Obstructive Pulmonary ... More >>Disease and Allied Conditions Less << | Phase 2 | Unknown | January 2016 | Austria ... More >> Deparment for Respiratory and Critical Care Medicine, Otto Wangner Hospital Vienna, Austria, 1140 Less << |
NCT01443845 | - | Completed | - | - | |
NCT03073798 | COPD Chronic ... More >>Bronchitis Emphysema Less << | Phase 4 | Completed | - | - |
NCT03458546 | Lymphoma, B-Cell | PHASE1 | COMPLETED | 2024-01-16 | Mays Cancer Center, UT Health ... More >>San Antonio, San Antonio, Texas, 78229, United States Less << |
NCT01365533 | Allergic Asthma | Phase 2 | Completed | - | Canada ... More >> Nycomed investigational site Quebec, Canada Less << |
NCT02165826 | - | Completed | - | - | |
NCT01830959 | Sarcoidosis | Phase 4 | Unknown | October 2016 | United States, Ohio ... More >> University of Cincinnati Cincinnati, Ohio, United States, 45267 Less << |
NCT02097992 | COPD | Phase 1 Phase 2 | Completed | - | United States, Florida ... More >> University of Miami Divison of Pulmonary and Critical Care Medicine Miami, Florida, United States, 33136 Less << |
NCT01862029 | Obesity | PHASE1|PHASE2 | COMPLETED | 2017-07-25 | National Institutes of Health ... More >>Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States Less << |
NCT02165826 | Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << | Phase 3 | Completed | - | Slovakia ... More >> Bardejov, Slovakia Spisska Nova Ves, Slovakia Less << |
NCT01862029 | Obesity | PHASE1|PHASE2 | COMPLETED | 2017-07-25 | National Institutes of Health ... More >>Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States Less << |
NCT02068456 | Chronic Obstructive Pulmonary ... More >>Disease Less << | COMPLETED | 2017-04-26 | Seoul, Korea, Republic of | |
NCT01354782 | Chronic Obstructive Pulmonary ... More >>Disease Less << | PHASE1 | COMPLETED | 2025-09-11 | Nycomed Investigational Site, ... More >>Beijing, 100032, China Less << |
NCT01849341 | Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << | Phase 4 | Completed | - | Spain ... More >> Hospital de Jerez Jerez de la Frontera, Cádiz, Spain Hospital Universitario Reina Sofía Córdoba, Spain H.U. Virgen de las Nieves Granada, Spain Hospital Universitario Virgen Macarena Sevilla, Spain Less << |
NCT01745848 | Chronic Obstructive Pulmonary ... More >>Disease Less << | PHASE4 | COMPLETED | 2016-06-30 | Emphysema COPD Research Center... More >>, Pittsburgh, Pennsylvania, 15213, United States Less << |
NCT02018432 | Chronic Obstructive Pulmonary ... More >>Disease Less << | Phase 4 | Unknown | December 2015 | Korea, Republic of ... More >> Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine Not yet recruiting Seoul, Korea, Republic of, 138-736 Contact: Sei Won Lee, MD ?? +82-3010-3990 ?? iseiwon@gmail.com Less << |
NCT01745848 | Chronic Obstructive Pulmonary ... More >>Disease Less << | PHASE4 | COMPLETED | 2016-06-30 | Emphysema COPD Research Center... More >>, Pittsburgh, Pennsylvania, 15213, United States Less << |
NCT03428334 | Non-cystic Fibrosis Bronchiect... More >>asis Less << | Phase 2 | Recruiting | August 31, 2019 | Hong Kong ... More >> Queen Mary Hospital Recruiting Hong Kong, Hong Kong Contact: James CM Ho, MD Less << |
NCT03381573 | COPD | COMPLETED | 2022-09-16 | Research Site, Cambridge, Mass... More >>achusetts, 02139, United States|Research Site, Bremen, Germany|Research Site, Oslo, 0483, Norway|Research Site, Solna, Sweden Less << | |
NCT03532490 | Asthma Obesit... More >>y Less << | Phase 2 | Recruiting | April 2020 | United States, Arizona ... More >> University of Arizona Active, not recruiting Tucson, Arizona, United States, 85724 United States, Illinois Northwestern University Feinberg School of Medicine Active, not recruiting Chicago, Illinois, United States, 60611 United States, New York Mount Sinai Icahn School of Medicine Active, not recruiting New York, New York, United States, 10029 United States, North Carolina Duke University Recruiting Durham, North Carolina, United States, 27705 Contact: Cathy Foss, BS ?? 919-479-0861 ?? catherine.foss@duke.edu ?? United States, Vermont University of Vermont Recruiting Colchester, Vermont, United States, 05446 Contact: Kathy Meehan ?? 802-847-8839 ?? kathy.meehan@uvmhealth.org Less << |
NCT04090294 | Bronchiectasis | EARLY_PHASE1 | UNKNOWN | 2025-11-20 | - |
NCT03764475 | Plaque Psoriasis | PHASE2 | COMPLETED | 2020-10-08 | Arcutis Clinical Site 35, Beve... More >>rly Hills, California, 90212, United States|Arcutis Clinical Site 29, Northridge, California, 91324, United States|Arcutis Clinical Site 28, San Diego, California, 92123, United States|Arcutis Clinical Site 27, Santa Monica, California, 90403, United States|Arcutis Clinical Site 12, Miami, Florida, 33144, United States|Arcutis Clinical Site 16, Sanford, Florida, 32771, United States|Arcutis Clinical Site 21, Louisville, Kentucky, 40217, United States|Arcutis Clinical Site 34, Clinton Township, Michigan, 48038, United States|Arcutis Clinical Site 33, Detroit, Michigan, 48202, United States|Arcutis Clinical Site 20, Fridley, Minnesota, 55432, United States|Arcutis Clinical Site 22, New York, New York, 10029, United States|Arcutis Clinical Site 14, High Point, North Carolina, 27262, United States|Arcutis Clinical Site 39, Bexley, Ohio, 43209, United States|Arcutis Clinical Site 15, Pittsburgh, Pennsylvania, 15213, United States|Arcutis Clinical Site 19, College Station, Texas, 77845, United States|Arcutis Clinical Site 37, Houston, Texas, 77004, United States|Arcutis Clinical Site 13, Houston, Texas, 77056, United States|Arcutis Clinical Site 23, San Antonio, Texas, 78213, United States|Arcutis Clinical Site 24, Webster, Texas, 77598, United States|Arcutis Clinical Site 31, Norfolk, Virginia, 23502, United States|Arcutis Clinical Site 18, Surrey, British Columbia, V3R 6A7, Canada|Arcutis Clinical Site 11, Surrey, British Columbia, V3V 0C6, Canada|Arcutis Clinical Site 38, Winnipeg, Manitoba, R3M 3Z4, Canada|Arcutis Clinical Site 10, Ajax, Ontario, L1S 7K8, Canada|Arcutis Clinical Site 25, London, Ontario, N6H 5L5, Canada|Arcutis Clinical Site 26, Markham, Ontario, L3P 1X2, Canada|Arcutis Clinical Site 32, Oakville, Ontario, L6J 7W5, Canada|Arcutis Clinical Site 17, Peterborough, Ontario, K9J 5K2, Canada|Arcutis Clinical Site 30, Waterloo, Ontario, N2J 1C4, Canada|Arcutis Clinical Site 36, Windsor, Ontario, N8W 1E6, Canada Less << |
NCT04549870 | Psoriasis | PHASE2 | COMPLETED | 2022-12-12 | Bispebjerg Hospital, Copenhage... More >>n, Denmark Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.48mL 0.50mL 0.25mL |
12.40mL 2.48mL 1.24mL |
24.80mL 4.96mL 2.48mL |