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Chemical Structure| 162401-32-3 Chemical Structure| 162401-32-3

Structure of Roflumilast
CAS No.: 162401-32-3

Chemical Structure| 162401-32-3

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CAS No.: 162401-32-3

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Roflumilast is a selective and long-acting inhibitor of PDE-4 with IC50 of 0.8 nM.

Synonyms: APTA-2217; BYK 20869; Daliresp

4.5 *For Research Use Only !

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Sohn, Jeferson ;

Abstract: Fear memory retrieval is at the core of signs and symptoms of post-traumatic stress disorder (PTSD) a psychiatric disease induced by extreme life-threatening events. Short RET induces reconsolidation, which upholds the original fear memory, while long retrieval triggers extinction, inhibiting the original fear memory expression. These processes engage neural circuits involving the dorsal hippocampus (DH) and medial prefrontal cortex regions like the pre-limbic cortex (PL). Additionally, these processes activate intracellular signaling pathways, such as those involving cyclic adenosine monophosphate (cAMP). Phosphodiesterase 4 (PDE4) regulates this pathway by degrading . Inhibiting PDE4 has been suggested as a strategy to alter memory processing. However, the role of PDE4 after a short fear memory retrieval remains unknown. Advancing this knowledge may contribute to the development of novel treatments for PTSD aimed at modifying memory reconsolidation or extinction. This study aimed to evaluate whether PDE4 inhibition after a short retrieval alters the behavioral outcomes induced by retrieval. For this purpose, adult male Wistar rats were exposed to contextual fear conditioning. After a short retrieval session, the animals were treated with (ROF; a PDE4 inhibitor) i.p. at doses of 0.01, 0.03, 0.1, or 0.3 mg/kg 5, 30 min, or 3 h after memory retrieval. After 1 and 10 days, the animals were re-exposed (3 min) to the conditioned context for Tests A1 and A2, respectively. Whereas no changes were observed during Test A1, the treatment with ROF 0.1 i.p. 5 min after retrieval significantly reduced freezing behavior in Test A2 suggesting a specific long-term effect. The expression of cAMP-response element binding (CREB), Brain-derived neurotrophic factor (BDNF), Zinc finger 268 (Zif268), or protein kinase Mζ (PKMζ) in the DH and the PL after retrieval, Test A1, and A2 were evaluated to assess the role of these proteins in memory regulation. The treatment with ROF 0.1 5 min after retrieval increased the expression of proBDNF (16 kDa) in the DH after Test A1 and reduced Zif268 expression in the PL after Test A2. To understand the role of the DH and the PL in the observed effects, ROF (9 ng/0.5 or 0.2 μL) was administered 5 min after retrieval directly into these regions. Accordingly, PDE4 inhibition (both involving PDE4B and PDE4D subtypes) in the DH significantly reduced freezing behavior in Test A2. Omitting the retrieval session or Test A1 reversed the ROF effects, indicating the effects depend on exposure to the conditioned context. Moreover, both extending the interval between retrieval and Test A1, inhibiting protein kinase A (PKA; after retrieval), or inhibiting protein synthesis (after Test A1) abolished the effects induced by ROF in the DH. The treatment with ROF in the DH induced effects sensitive to reinstatement and facilitated extinction in the day after treatment, favoring the interpretation that the effects of ROF after a short retrieval session are related to extinction but not reconsolidation. However, ROF administered directly in the PL sustained fear expression in Test A1, whereas there were no significant differences in Test A2. Therefore, it was evaluated whether ROF treatment after conditioning favors fear memory. However, treatment with 0.1 ROF i.p. impaired fear memory consolidation in weak training. To evaluate whether the same pattern of results occurred in another type of memory, the effects of ROF treatment on object recognition memory were assessed. Treatment with 0.1 ROF i.p. improved reconsolidation when administered 5 min after the retrieval and improved consolidation when administered 3 h after training. The results suggest that inhibiting PDE4 after a short retrieval induces, upon re-exposure to the conditioned context, memory extinction at a time that typically leads to reconsolidation. This effect is PKA-dependent and related to increased proBDNF in the DH. The results of this study suggest that after a short fear memory retrieval, it is possible to modify the memory fate from reconsolidation to extinction, a mechanism that involves PDE4 inhibition.

Keywords: Extinction ; Hippocampus ; Pre-limbic ; ; Reconsolidation

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Alternative Products

Product Details of Roflumilast

CAS No. :162401-32-3
Formula : C17H14Cl2F2N2O3
M.W : 403.21
SMILES Code : O=C(NC1=C(Cl)C=NC=C1Cl)C2=CC=C(OC(F)F)C(OCC3CC3)=C2
Synonyms :
APTA-2217; BYK 20869; Daliresp
MDL No. :MFCD00938270
InChI Key :MNDBXUUTURYVHR-UHFFFAOYSA-N
Pubchem ID :449193

Safety of Roflumilast

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • PDE4

    PDE4A4, IC50:4.3 nM

    PDE4A1, IC50:0.7 nM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03762330 Chronic Obstructive Pulmonary ... More >>Disease Less << Not Applicable Not yet recruiting January 2021 -
NCT02835716 - Recruiting September 2020 United States, Connecticut ... More >> Millennium Magnetic Technologies, LLC Recruiting Westport, Connecticut, United States, 06880 Contact: Steve Levy, MD ?? 203-423-9494 ?? SL@MilMag.net ?? Contact: Donald H Marks, MD PhD ?? 9733070364 ?? DHM@MilMag.net Less <<
NCT01730404 COPD Phase 2 Completed - Ireland ... More >> Celerion Belfast, Ireland United Kingdom Parexel, early phases Harrow, United Kingdom Medicines Evaluation Unit Ltd Manchester, United Kingdom Freeman Hospital Newcastle, United Kingdom Nottingham University Hospitals NHS Trust Nottingham, United Kingdom Less <<
NCT00613587 - Completed - United States, Nebraska ... More >> Creighton University Medical Center Omaha, Nebraska, United States, 68131 Less <<
NCT02363335 Healthy Volunteers Phase 1 Completed - United States, Maryland ... More >> National Institute of Aging, Clinical Research Unit Baltimore, Maryland, United States, 21224 Less <<
NCT01580748 Symptomatic Bronchiectasis PHASE2 UNKNOWN 2025-01-13 Seoul National University Bund... More >>ang Hospital, Seongnam, Gyeongi-do, 463-707, Korea, Republic of Less <<
NCT02340520 - Completed - -
NCT00242294 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << PHASE2|PHASE3 COMPLETED 2025-03-07 Nycomed Japan and Mitsubishi T... More >>anabe Oharma Corporation, Osaka, Japan Less <<
NCT02340520 COPD Phase 3 Completed - United States, Connecticut ... More >> UConnHealth Farmington, Connecticut, United States, 06032 Less <<
NCT00108823 Chronic Obstructive Pulmonary ... More >>Disease, COPD Less << PHASE3 COMPLETED - ALTANA Pharma, Cities in Calif... More >>ornia, California, United States|ALTANA Pharma, Cities in Colorado, Colorado, United States|ALTANA Pharma, Cities in Florida, Florida, United States|ALTANA Pharma, Cities in Missouri, Missouri, United States|ALTANA Pharma, Cities in New Mexico, New Mexico, United States|ALTANA Pharma, Cities in New York, New York, United States|ALTANA Pharma, Cities in Oregeon, Oregon, United States|ALTANA Pharma, Cities in South Carolina, South Carolina, United States|ALTANA Pharma, Cities in Texas, Texas, United States|ALTANA Pharma, Cities in Washington, Washington, United States|ALTANA Pharma, Cities in Canada, Canada|ALTANA Pharma, Cities in France, France|ALTANA Pharma, Cities in Poland, Poland|ALTANA Pharma, Cities in South Africa, South Africa|ALTANA Pharma, Cities in Spain, Spain|ALTANA Pharma, Cities in the United Kingdom, United Kingdom Less <<
NCT01285180 - Completed - -
NCT01285167 Chronic Obstructive Pulmonary ... More >>Disease Less << COMPLETED 2025-02-12 Nycomed Deutschland GmbH, Ahle... More >>n, 59227, Germany|Nycomed Deutschland GmbH, Ahlen, 59229, Germany|Nycomed Deutschland GmbH, Allendorf, 35108, Germany|Nycomed Deutschland GmbH, Allersberg, 90584, Germany|Nycomed Deutschland GmbH, Alpenrod, 57642, Germany|Nycomed Deutschland GmbH, Altena, 58762, Germany|Nycomed Deutschland GmbH, Altenburg, 04600, Germany|Nycomed Deutschland GmbH, Alzenau, 63755, Germany|Nycomed Deutschland GmbH, Alzey, 55232, Germany|Nycomed Deutschland GmbH, Amberg, 92224, Germany|Nycomed Deutschland GmbH, Anklam, 17389, Germany|Nycomed Deutschland GmbH, Annaberg-Buchholz, 09456, Germany|Nycomed Deutschland GmbH, Arnsberg, 59821, Germany|Nycomed Deutschland GmbH, Aschaffenburg, 63739, Germany|Nycomed Deutschland GmbH, Aschaffenburg, 63743, Germany|Nycomed Deutschland GmbH, Attendorn, 57439, Germany|Nycomed Deutschland GmbH, Attenkirchen, 85395, Germany|Nycomed Deutschland GmbH, Auerbach, 08209, Germany|Nycomed Deutschland GmbH, Augsburg, 86150, Germany|Nycomed Deutschland GmbH, Augsburg, 86156, Germany|Nycomed Deutschland GmbH, Backnang, 71522, Germany|Nycomed Deutschland GmbH, Bad Doberan, 18209, Germany|Nycomed Deutschland GmbH, Bad Endorf, 83093, Germany|Nycomed Deutschland GmbH, Bad Essen, 49152, Germany|Nycomed Deutschland GmbH, Bad Freienwalde, 16259, Germany|Nycomed Deutschland GmbH, Bad Füssing, 94072, Germany|Nycomed Deutschland GmbH, Bad Honnef, 53604, Germany|Nycomed Deutschland GmbH, Bad Langensalza, 99947, Germany|Nycomed Deutschland GmbH, Bad Lippspringe, 33175, Germany|Nycomed Deutschland GmbH, Bad Reichenhall, 83435, Germany|Nycomed Deutschland GmbH, Bad Salzuflen, 32105, Germany|Nycomed Deutschland GmbH, Bad Salzuflen, 32108, Germany|Nycomed Deutschland GmbH, Bad Salzungen, 36433, Germany|Nycomed Deutschland GmbH, Bad Soden-Salmünster, 63628, Germany|Nycomed Deutschland GmbH, Bad Soden, 65812, Germany|Nycomed Deutschland GmbH, Bad Tennstedt, 99955, Germany|Nycomed Deutschland GmbH, Bad W?rishofen, 86825, Germany|Nycomed Deutschland GmbH, Badel, 39624, Germany|Nycomed Deutschland GmbH, Baden-Baden, 76530, Germany|Nycomed Deutschland GmbH, Bamberg, 96047, Germany|Nycomed Deutschland GmbH, Bamberg, 96049, Germany|Nycomed Deutschland GmbH, Bargteheide, 22941, Germany|Nycomed Deutschland GmbH, Baunatal, 34225, Germany|Nycomed Deutschland GmbH, Bausendorf, 54538, Germany|Nycomed Deutschland GmbH, Bautzen, 02625, Germany|Nycomed Deutschland GmbH, Beelitz, 14547, Germany|Nycomed Deutschland GmbH, Bensheim, 64625, Germany|Nycomed Deutschland GmbH, Bergisch Gladbach, 51429, Germany|Nycomed Deutschland GmbH, Bergisch Gladbach, 51465, Germany|Nycomed Deutschland GmbH, Bergkamen, 59192, Germany|Nycomed Deutschland GmbH, Bergneustadt, 51702, Germany|Nycomed Deutschland GmbH, Berlin, 10117, Germany|Nycomed Deutschland GmbH, Berlin, 10247, Germany|Nycomed Deutschland GmbH, Berlin, 10318, Germany|Nycomed Deutschland GmbH, Berlin, 10365, Germany|Nycomed Deutschland GmbH, Berlin, 10367, Germany|Nycomed Deutschland GmbH, Berlin, 10559, Germany|Nycomed Deutschland GmbH, Berlin, 10625, Germany|Nycomed Deutschland GmbH, Berlin, 10627, Germany|Nycomed Deutschland GmbH, Berlin, 10711, Germany|Nycomed Deutschland GmbH, Berlin, 10717, Germany|Nycomed Deutschland GmbH, Berlin, 10789, Germany|Nycomed Deutschland GmbH, Berlin, 10961, Germany|Nycomed Deutschland GmbH, Berlin, 12043, Germany|Nycomed Deutschland GmbH, Berlin, 12099, Germany|Nycomed Deutschland GmbH, Berlin, 12157, Germany|Nycomed Deutschland GmbH, Berlin, 12165, Germany|Nycomed Deutschland GmbH, Berlin, 12203, Germany|Nycomed Deutschland GmbH, Berlin, 12279, Germany|Nycomed Deutschland GmbH, Berlin, 12555, Germany|Nycomed Deutschland GmbH, Berlin, 12627, Germany|Nycomed Deutschland GmbH, Berlin, 12679, Germany|Nycomed Deutschland GmbH, Berlin, 12687, Germany|Nycomed Deutschland GmbH, Berlin, 13055, Germany|Nycomed Deutschland GmbH, Berlin, 13057, Germany|Nycomed Deutschland GmbH, Berlin, 13156, Germany|Nycomed Deutschland GmbH, Berlin, 13187, Germany|Nycomed Deutschland GmbH, Berlin, 13353, Germany|Nycomed Deutschland GmbH, Berlin, 13405, Germany|Nycomed Deutschland GmbH, Berlin, 13465, Germany|Nycomed Deutschland GmbH, Berlin, 13507, Germany|Nycomed Deutschland GmbH, Berlin, 13581, Germany|Nycomed Deutschland GmbH, Berlin, 14052, Germany|Nycomed Deutschland GmbH, Berlin, 14059, Germany|Nycomed Deutschland GmbH, Bernau, 16321, Germany|Nycomed Deutschland GmbH, Biedenkopf, 35216, Germany|Nycomed Deutschland GmbH, Bielefeld, 33647, Germany|Nycomed Deutschland GmbH, Bietigheim-Bissingen, 74321, Germany|Nycomed Deutschland GmbH, Bitterfeld, 06749, Germany|Nycomed Deutschland GmbH, Blankenhain, 99444, Germany|Nycomed Deutschland GmbH, Bochum, 44866, Germany|Nycomed Deutschland GmbH, Bochum, 44879, Germany|Nycomed Deutschland GmbH, Bondorf, 71149, Germany|Nycomed Deutschland GmbH, Bonndorf, 79848, Germany|Nycomed Deutschland GmbH, Bonn, 53111, Germany|Nycomed Deutschland GmbH, Bonn, 53113, Germany|Nycomed Deutschland GmbH, Bonn, 53119, Germany|Nycomed Deutschland GmbH, Bonn, 53123, Germany|Nycomed Deutschland GmbH, Bonn, 53225, Germany|Nycomed Deutschland GmbH, Bottrop, 46236, Germany|Nycomed Deutschland GmbH, Bottrop, 46240, Germany|Nycomed Deutschland GmbH, Bovenden, 37120, Germany|Nycomed Deutschland GmbH, Braunfels, 35619, Germany|Nycomed Deutschland GmbH, Braunsbedra, 06242, Germany|Nycomed Deutschland GmbH, Braunschweig, 38100, Germany|Nycomed Deutschland GmbH, Braunschweig, 38106, Germany|Nycomed Deutschland GmbH, Bredstedt, 25821, Germany|Nycomed Deutschland GmbH, Breitengü?bach, 96149, Germany|Nycomed Deutschland GmbH, Bremerhaven, 27570, Germany|Nycomed Deutschland GmbH, Bremerhaven, 27578, Germany|Nycomed Deutschland GmbH, Bremerhaven, 27580, Germany|Nycomed Deutschland GmbH, Brilon, 59929, Germany|Nycomed Deutschland GmbH, Bruchsal, 76646, Germany|Nycomed Deutschland GmbH, Brunsbüttel, 25541, Germany|Nycomed Deutschland GmbH, Buckow, 15377, Germany|Nycomed Deutschland GmbH, Bunde, 26831, Germany|Nycomed Deutschland GmbH, Burgau, 89331, Germany|Nycomed Deutschland GmbH, Burgst?dt, 09217, Germany|Nycomed Deutschland GmbH, Burgwedel, 30938, Germany|Nycomed Deutschland GmbH, Büchen, 21514, Germany|Nycomed Deutschland GmbH, Büddenstedt, 38372, Germany|Nycomed Deutschland GmbH, Bünde, 32257, Germany|Nycomed Deutschland GmbH, Calau, 03205, Germany|Nycomed Deutschland GmbH, Callenberg, 09337, Germany|Nycomed Deutschland GmbH, Camburg, 07774, Germany|Nycomed Deutschland GmbH, Celle, 29221, Germany|Nycomed Deutschland GmbH, Chemnitz, 09126, Germany|Nycomed Deutschland GmbH, Coburg, 96450, Germany|Nycomed Deutschland GmbH, Cottbus, 03050, Germany|Nycomed Deutschland GmbH, Crimmitschau, 08451, Germany|Nycomed Deutschland GmbH, Darmstadt, 64287, Germany|Nycomed Deutschland GmbH, Deggendorf, 94469, Germany|Nycomed Deutschland GmbH, Deggingen, 73326, Germany|Nycomed Deutschland GmbH, Dessau, 06844, Germany|Nycomed Deutschland GmbH, Dessau, 06846, Germany|Nycomed Deutschland GmbH, Dillingen, 66763, Germany|Nycomed Deutschland GmbH, Dillingen, 89407, Germany|Nycomed Deutschland GmbH, Dinslaken, 46535, Germany|Nycomed Deutschland GmbH, Dommitzsch, 04880, Germany|Nycomed Deutschland GmbH, Dornstetten, 72280, Germany|Nycomed Deutschland GmbH, Dorsten, 46284, Germany|Nycomed Deutschland GmbH, Dortmund, 44135, Germany|Nycomed Deutschland GmbH, Dortmund, 44388, Germany|Nycomed Deutschland GmbH, Dresden, 01099, Germany|Nycomed Deutschland GmbH, Dresden, 01187, Germany|Nycomed Deutschland GmbH, Dresden, 01307, Germany|Nycomed Deutschland GmbH, Duisburg, 47137, Germany|Nycomed Deutschland GmbH, Duisburg, 47198, Germany|Nycomed Deutschland GmbH, D?rentrup, 32694, Germany|Nycomed Deutschland GmbH, Düren, 52349, Germany|Nycomed Deutschland GmbH, Düsseldorf, 40211, Germany|Nycomed Deutschland GmbH, Düsseldorf, 40217, Germany|Nycomed Deutschland GmbH, Düsseldorf, 40231, Germany|Nycomed Deutschland GmbH, Düsseldorf, 40237, Germany|Nycomed Deutschland GmbH, Düsseldorf, 40489, Germany|Nycomed Deutschland GmbH, Eberswalde, 16225, Germany|Nycomed Deutschland GmbH, Eggenfelden, 84307, Germany|Nycomed Deutschland GmbH, Ehra-Lessien, 38468, Germany|Nycomed Deutschland GmbH, Ehrenkirchen, 79238, Germany|Nycomed Deutschland GmbH, Einbeck, 37574, Germany|Nycomed Deutschland GmbH, Eisenach, 99817, Germany|Nycomed Deutschland GmbH, Ellerstadt, 67158, Germany|Nycomed Deutschland GmbH, Ellrich, 99755, Germany|Nycomed Deutschland GmbH, Ellwangen (Jagst), 73479, Germany|Nycomed Deutschland GmbH, Emsdetten, 48282, Germany|Nycomed Deutschland GmbH, Emskirchen, 91448, Germany|Nycomed Deutschland GmbH, Ennepetal, 58256, Germany|Nycomed Deutschland GmbH, Erfde, 24803, Germany|Nycomed Deutschland GmbH, Erfurt, 99084, Germany|Nycomed Deutschland GmbH, Erfurt, 99086, Germany|Nycomed Deutschland GmbH, Erfurt, 99089, Germany|Nycomed Deutschland GmbH, Erfurt, 99099, Germany|Nycomed Deutschland GmbH, Erlangen, 91052, Germany|Nycomed Deutschland GmbH, Eschau, 63863, Germany|Nycomed Deutschland GmbH, Eschwege, 37269, Germany|Nycomed Deutschland GmbH, Eschweiler, 52249, Germany|Nycomed Deutschland GmbH, Essenheim, 55270, Germany|Nycomed Deutschland GmbH, Essen, 45127, Germany|Nycomed Deutschland GmbH, Essen, 45131, Germany|Nycomed Deutschland GmbH, Essen, 45279, Germany|Nycomed Deutschland GmbH, Essen, 45307, Germany|Nycomed Deutschland GmbH, Essen, 45329, Germany|Nycomed Deutschland GmbH, Essen, 45355, Germany|Nycomed Deutschland GmbH, Essen, 45357, Germany|Nycomed Deutschland GmbH, Esslingen, 73734, Germany|Nycomed Deutschland GmbH, Ettlingen, 76275, Germany|Nycomed Deutschland GmbH, Eutin, 23701, Germany|Nycomed Deutschland GmbH, Falkensee, 14612, Germany|Nycomed Deutschland GmbH, Feldberger Seenlandschaft, 17258, Germany|Nycomed Deutschland GmbH, Flensburg, 24937, Germany|Nycomed Deutschland GmbH, Fl?ha, 09557, Germany|Nycomed Deutschland GmbH, Frankenthal, 67227, Germany|Nycomed Deutschland GmbH, Frankfurt am Main, 60596, Germany|Nycomed Deutschland GmbH, Frankfurt, 15230, Germany|Nycomed Deutschland GmbH, Frankfurt, 15232, Germany|Nycomed Deutschland GmbH, Frankfurt, 60389, Germany|Nycomed Deutschland GmbH, Frankfurt, 60487, Germany|Nycomed Deutschland GmbH, Frankfurt, 60528, Germany|Nycomed Deutschland GmbH, Freising, 85354, Germany|Nycomed Deutschland GmbH, Friedrichshafen, 88046, Germany|Nycomed Deutschland GmbH, Friedrichshafen, 88048, Germany|Nycomed Deutschland GmbH, Fulda, 36039, Germany|Nycomed Deutschland GmbH, Fürstenfeldbruck, 82256, Germany|Nycomed Deutschland GmbH, Fürstenwalde, 15517, Germany|Nycomed Deutschland GmbH, Fürth, 90762, Germany|Nycomed Deutschland GmbH, Fürth, 90766, Germany|Nycomed Deutschland GmbH, Ganderkesee, 27777, Germany|Nycomed Deutschland GmbH, Gardelegen, 39638, Germany|Nycomed Deutschland GmbH, Garmisch-Partenkirchen, 82467, Germany|Nycomed Deutschland GmbH, Gauting, 82131, Germany|Nycomed Deutschland GmbH, Gelsenkirchen, 45879, Germany|Nycomed Deutschland GmbH, Gelsenkirchen, 45881, Germany|Nycomed Deutschland GmbH, Gelsenkirchen, 45891, Germany|Nycomed Deutschland GmbH, Gelsenkirchen, 45894, Germany|Nycomed Deutschland GmbH, Gelsenkirchen, 45897, Germany|Nycomed Deutschland GmbH, Gemünden, 97737, Germany|Nycomed Deutschland GmbH, Germering, 82110, Germany|Nycomed Deutschland GmbH, Gifhorn, 38518, Germany|Nycomed Deutschland GmbH, Gladbeck, 45966, Germany|Nycomed Deutschland GmbH, Gladbeck, 45968, Germany|Nycomed Deutschland GmbH, Glauchau, 08371, Germany|Nycomed Deutschland GmbH, Goch, 47574, Germany|Nycomed Deutschland GmbH, Gotha, 99867, Germany|Nycomed Deutschland GmbH, Grebenstein, 34393, Germany|Nycomed Deutschland GmbH, Grefrath, 47929, Germany|Nycomed Deutschland GmbH, Greiz, 07973, Germany|Nycomed Deutschland GmbH, Grimmen, 18507, Germany|Nycomed Deutschland GmbH, Gro? Kreutz, 14550, Germany|Nycomed Deutschland GmbH, Gro?aitingen, 86845, Germany|Nycomed Deutschland GmbH, Gro?efehn, 26629, Germany|Nycomed Deutschland GmbH, Gro?korbetha, 06688, Germany|Nycomed Deutschland GmbH, Gro?schirma, 09603, Germany|Nycomed Deutschland GmbH, Gr?fenhainichen, 06773, Germany|Nycomed Deutschland GmbH, Gr?mitz, 23743, Germany|Nycomed Deutschland GmbH, Gütersloh, 33330, Germany|Nycomed Deutschland GmbH, Hagen, 58089, Germany|Nycomed Deutschland GmbH, Hagen, 58095, Germany|Nycomed Deutschland GmbH, Hagen, 58135, Germany|Nycomed Deutschland GmbH, Haibach, 63808, Germany|Nycomed Deutschland GmbH, Halberstadt, 38820, Germany|Nycomed Deutschland GmbH, Halbe, 15757, Germany|Nycomed Deutschland GmbH, Halle (Saale), 06114, Germany|Nycomed Deutschland GmbH, Halle, 06108, Germany|Nycomed Deutschland GmbH, Halle, 06110, Germany|Nycomed Deutschland GmbH, Halle, 06132, Germany|Nycomed Deutschland GmbH, Halle, 33790, Germany|Nycomed Deutschland GmbH, Halstenbek, 25469, Germany|Nycomed Deutschland GmbH, Hamburg, 20255, Germany|Nycomed Deutschland GmbH, Hamburg, 20354, Germany|Nycomed Deutschland GmbH, Hamburg, 20359, Germany|Nycomed Deutschland GmbH, Hamburg, 20537, Germany|Nycomed Deutschland GmbH, Hamburg, 21029, Germany|Nycomed Deutschland GmbH, Hamburg, 22041, Germany|Nycomed Deutschland GmbH, Hamburg, 22299, Germany|Nycomed Deutschland GmbH, Hamburg, 22527, Germany|Nycomed Deutschland GmbH, Hamburg, 22767, Germany|Nycomed Deutschland GmbH, Hammelburg, 97762, Germany|Nycomed Deutschland GmbH, Hann. Münden, 34346, Germany|Nycomed Deutschland GmbH, Hannover, 30161, Germany|Nycomed Deutschland GmbH, Hannover, 30163, Germany|Nycomed Deutschland GmbH, Hannover, 30173, Germany|Nycomed Deutschland GmbH, Hannover, 30449, Germany|Nycomed Deutschland GmbH, Hannover, 30625, Germany|Nycomed Deutschland GmbH, Haren, 49733, Germany|Nycomed Deutschland GmbH, Hartha, 04746, Germany|Nycomed Deutschland GmbH, Haselünne, 49740, Germany|Nycomed Deutschland GmbH, Ha?loch, 67454, Germany|Nycomed Deutschland GmbH, Heidelberg, 69115, Germany|Nycomed Deutschland GmbH, Heilbronn, 74072, Germany|Nycomed Deutschland GmbH, Heilbronn, 74080, Germany|Nycomed Deutschland GmbH, Heiligenhafen, 23774, Germany|Nycomed Deutschland GmbH, Heiligenhaus, 42579, Germany|Nycomed Deutschland GmbH, Heimbuchenthal, 63872, Germany|Nycomed Deutschland GmbH, Hemmingen, 30966, Germany|Nycomed Deutschland GmbH, Herbsleben, 99955, Germany|Nycomed Deutschland GmbH, Herne, 44623, Germany|Nycomed Deutschland GmbH, Herne, 44629, Germany|Nycomed Deutschland GmbH, Herne, 44649, Germany|Nycomed Deutschland GmbH, Herne, 44651, Germany|Nycomed Deutschland GmbH, Herzlake, 49770, Germany|Nycomed Deutschland GmbH, Hettstedt, 06333, Germany|Nycomed Deutschland GmbH, Hille, 32429, Germany|Nycomed Deutschland GmbH, Hohenm?lsen, 06679, Germany|Nycomed Deutschland GmbH, Homberg, 34576, Germany|Nycomed Deutschland GmbH, Homburg, 66424, Germany|Nycomed Deutschland GmbH, Horb, 72160, Germany|Nycomed Deutschland GmbH, Hoyerswerda, 02977, Germany|Nycomed Deutschland GmbH, H?chstadt, 91315, Germany|Nycomed Deutschland GmbH, Ibbenbüren, 49477, Germany|Nycomed Deutschland GmbH, Idstein, 65510, Germany|Nycomed Deutschland GmbH, Illerrieden, 89186, Germany|Nycomed Deutschland GmbH, Iserlohn, 58636, Germany|Nycomed Deutschland GmbH, Issum, 47661, Germany|Nycomed Deutschland GmbH, Itzehoe, 25524, Germany|Nycomed Deutschland GmbH, Jessen, 06917, Germany|Nycomed Deutschland GmbH, Jettingen, 71131, Germany|Nycomed Deutschland GmbH, Johannesberg, 63867, Germany|Nycomed Deutschland GmbH, Jübek, 24855, Germany|Nycomed Deutschland GmbH, Kaiserslautern, 67655, Germany|Nycomed Deutschland GmbH, Kamenz, 01917, Germany|Nycomed Deutschland GmbH, Kamen, 59174, Germany|Nycomed Deutschland GmbH, Kandern, 79400, Germany|Nycomed Deutschland GmbH, Karlsruhe, 76227, Germany|Nycomed Deutschland GmbH, Kempten, 87435, Germany|Nycomed Deutschland GmbH, Kevelaer, 47623, Germany|Nycomed Deutschland GmbH, Kirchenlamitz, 95154, Germany|Nycomed Deutschland GmbH, Kirchheim, 73230, Germany|Nycomed Deutschland GmbH, Kleinostheim, 63801, Germany|Nycomed Deutschland GmbH, Klingenberg, 63911, Germany|Nycomed Deutschland GmbH, Koblenz, 56068, Germany|Nycomed Deutschland GmbH, Koblenz, 56070, Germany|Nycomed Deutschland GmbH, Konstanz, 78462, Germany|Nycomed Deutschland GmbH, Kornwestheim, 70806, Germany|Nycomed Deutschland GmbH, Krefeld, 47803, Germany|Nycomed Deutschland GmbH, Krefeld, 47805, Germany|Nycomed Deutschland GmbH, Krumbach, 86381, Germany|Nycomed Deutschland GmbH, Krummh?rn, 26736, Germany|Nycomed Deutschland GmbH, Kyritz, 16866, Germany|Nycomed Deutschland GmbH, K?ln, 50672, Germany|Nycomed Deutschland GmbH, K?ln, 50733, Germany|Nycomed Deutschland GmbH, K?ln, 50825, Germany|Nycomed Deutschland GmbH, K?ln, 50931, Germany|Nycomed Deutschland GmbH, K?ln, 50937, Germany|Nycomed Deutschland GmbH, K?ln, 50996, Germany|Nycomed Deutschland GmbH, K?ln, 51061, Germany|Nycomed Deutschland GmbH, K?ln, 51063, Germany|Nycomed Deutschland GmbH, K?nigs Wusterhausen, 15711, Germany|Nycomed Deutschland GmbH, K?then, 06366, Germany|Nycomed Deutschland GmbH, Laage, 18299, Germany|Nycomed Deutschland GmbH, Lahr, 77933, Germany|Nycomed Deutschland GmbH, Lambrecht, 67466, Germany|Nycomed Deutschland GmbH, Landshut, 84036, Germany|Nycomed Deutschland GmbH, Langenfeld, 40764, Germany|Nycomed Deutschland GmbH, Langenhagen, 30851, Germany|Nycomed Deutschland GmbH, Langwedel, 27299, Germany|Nycomed Deutschland GmbH, Lathen, 49762, Germany|Nycomed Deutschland GmbH, Laubach, 35321, Germany|Nycomed Deutschland GmbH, Lehre, 38165, Germany|Nycomed Deutschland GmbH, Leipzig, 04103, Germany|Nycomed Deutschland GmbH, Leipzig, 04107, Germany|Nycomed Deutschland GmbH, Leipzig, 04157, Germany|Nycomed Deutschland GmbH, Leipzig, 04205, Germany|Nycomed Deutschland GmbH, Leipzig, 04207, Germany|Nycomed Deutschland GmbH, Leipzig, 04275, Germany|Nycomed Deutschland GmbH, Leipzig, 04357, Germany|Nycomed Deutschland GmbH, Lensahn, 23738, Germany|Nycomed Deutschland GmbH, Leonberg, 71229, Germany|Nycomed Deutschland GmbH, Leverkusen, 51371, Germany|Nycomed Deutschland GmbH, Leverkusen, 51373, Germany|Nycomed Deutschland GmbH, Lichtenfels, 96215, Germany|Nycomed Deutschland GmbH, Limbach-Oberfrohna, 09212, Germany|Nycomed Deutschland GmbH, Limburg, 65549, Germany|Nycomed Deutschland GmbH, Lindenfels, 64678, Germany|Nycomed Deutschland GmbH, Lippetal, 59510, Germany|Nycomed Deutschland GmbH, Lippstadt, 59555, Germany|Nycomed Deutschland GmbH, Ludwigshafen, 67063, Germany|Nycomed Deutschland GmbH, Ludwigslust, 19288, Germany|Nycomed Deutschland GmbH, Lutherstadt Wittenberg, 06886, Germany|Nycomed Deutschland GmbH, L?bau, 02708, Germany|Nycomed Deutschland GmbH, L?hne, 32584, Germany|Nycomed Deutschland GmbH, Lübeck, 23552, Germany|Nycomed Deutschland GmbH, Lübeck, 23558, Germany|Nycomed Deutschland GmbH, Lühmannsdorf, 17495, Germany|Nycomed Deutschland GmbH, Lüneburg, 21335, Germany|Nycomed Deutschland GmbH, Lützen, 06686, Germany|Nycomed Deutschland GmbH, Magdeburg, 39104, Germany|Nycomed Deutschland GmbH, Magdeburg, 39112, Germany|Nycomed Deutschland GmbH, Mainz, 55122, Germany|Nycomed Deutschland GmbH, Mannheim, 68161, Germany|Nycomed Deutschland GmbH, Mannheim, 68165, Germany|Nycomed Deutschland GmbH, Mannheim, 68309, Germany|Nycomed Deutschland GmbH, Marburg, 35037, Germany|Nycomed Deutschland GmbH, Marienhafe, 26529, Germany|Nycomed Deutschland GmbH, Marienheide, 51709, Germany|Nycomed Deutschland GmbH, Marl, 45770, Germany|Nycomed Deutschland GmbH, Meckenbeuren, 88074, Germany|Nycomed Deutschland GmbH, Meckenheim, 53340, Germany|Nycomed Deutschland GmbH, Meerbusch, 40668, Germany|Nycomed Deutschland GmbH, Meisenheim, 55590, Germany|Nycomed Deutschland GmbH, Menden, 58706, Germany|Nycomed Deutschland GmbH, Mendig, 56743, Germany|Nycomed Deutschland GmbH, Merchweiler, 66589, Germany|Nycomed Deutschland GmbH, Merseburg, 06217, Germany|Nycomed Deutschland GmbH, Mertendorf, 06618, Germany|Nycomed Deutschland GmbH, Meuselwitz, 04610, Germany|Nycomed Deutschland GmbH, Miesbach, 83714, Germany|Nycomed Deutschland GmbH, Minden, 32423, Germany|Nycomed Deutschland GmbH, Minden, 32425, Germany|Nycomed Deutschland GmbH, Moers, 47441, Germany|Nycomed Deutschland GmbH, Monheim, 40789, Germany|Nycomed Deutschland GmbH, Moormerland, 26802, Germany|Nycomed Deutschland GmbH, M?nchengladbach, 41061, Germany|Nycomed Deutschland GmbH, M?nchengladbach, 41199, Germany|Nycomed Deutschland GmbH, M?nchengladbach, 41236, Germany|Nycomed Deutschland GmbH, Mülheim, 45468, Germany|Nycomed Deutschland GmbH, München, 80336, Germany|Nycomed Deutschland GmbH, München, 80539, Germany|Nycomed Deutschland GmbH, München, 80686, Germany|Nycomed Deutschland GmbH, München, 80802, Germany|Nycomed Deutschland GmbH, München, 81241, Germany|Nycomed Deutschland GmbH, München, 81243, Germany|Nycomed Deutschland GmbH, München, 81377, Germany|Nycomed Deutschland GmbH, München, 81667, Germany|Nycomed Deutschland GmbH, München, 81677, Germany|Nycomed Deutschland GmbH, Münster, 48143, Germany|Nycomed Deutschland GmbH, Münster, 48145, Germany|Nycomed Deutschland GmbH, Münster, 48157, Germany|Nycomed Deutschland GmbH, Münzenberg, 35516, Germany|Nycomed Deutschland GmbH, Nauen, 14641, Germany|Nycomed Deutschland GmbH, Neckartailfingen, 72666, Germany|Nycomed Deutschland GmbH, Nettersheim, 53947, Germany|Nycomed Deutschland GmbH, Neuhausen, 78579, Germany|Nycomed Deutschland GmbH, Neumarkt, 92318, Germany|Nycomed Deutschland GmbH, Neunkirchen, 66538, Germany|Nycomed Deutschland GmbH, Neuss, 41460, Germany|Nycomed Deutschland GmbH, Neuss, 41466, Germany|Nycomed Deutschland GmbH, Neustadt, 07806, Germany|Nycomed Deutschland GmbH, Neustadt, 35279, Germany|Nycomed Deutschland GmbH, Neuwied, 56564, Germany|Nycomed Deutschland GmbH, Nienburg, 31582, Germany|Nycomed Deutschland GmbH, Nordstemmen, 31171, Germany|Nycomed Deutschland GmbH, Nossen, 01683, Germany|Nycomed Deutschland GmbH, Nürnberg, 90402, Germany|Nycomed Deutschland GmbH, Nürnberg, 90439, Germany|Nycomed Deutschland GmbH, Nürnberg, 90441, Germany|Nycomed Deutschland GmbH, Nürnberg, 90443, Germany|Nycomed Deutschland GmbH, Nürnberg, 90451, Germany|Nycomed Deutschland GmbH, Nürnberg, 90459, Germany|Nycomed Deutschland GmbH, Obernzenn, 91619, Germany|Nycomed Deutschland GmbH, Oberursel, 61440, Germany|Nycomed Deutschland GmbH, Oer-Erkenschwick, 45739, Germany|Nycomed Deutschland GmbH, Offenbach am Main, 63067, Germany|Nycomed Deutschland GmbH, Offenbach, 63065, Germany|Nycomed Deutschland GmbH, Offenburg, 77654, Germany|Nycomed Deutschland GmbH, Oranienburg, 16515, Germany|Nycomed Deutschland GmbH, Ornbau, 91737, Germany|Nycomed Deutschland GmbH, Oschatz, 04758, Germany|Nycomed Deutschland GmbH, Oschersleben, 39387, Germany|Nycomed Deutschland GmbH, Osnabrück, 49074, Germany|Nycomed Deutschland GmbH, Osnabrück, 49076, Germany|Nycomed Deutschland GmbH, Osterode, 37520, Germany|Nycomed Deutschland GmbH, Ostrhauderfehn, 26842, Germany|Nycomed Deutschland GmbH, Paderborn, 33100, Germany|Nycomed Deutschland GmbH, Papenburg, 26871, Germany|Nycomed Deutschland GmbH, Parchim, 19370, Germany|Nycomed Deutschland GmbH, Pforzheim, 75179, Germany|Nycomed Deutschland GmbH, Pinneberg, 25421, Germany|Nycomed Deutschland GmbH, Pirmasens, 66955, Germany|Nycomed Deutschland GmbH, Plauen, 08523, Germany|Nycomed Deutschland GmbH, Plauen, 08525, Germany|Nycomed Deutschland GmbH, Potsdam, 14467, Germany|Nycomed Deutschland GmbH, Potsdam, 14478, Germany|Nycomed Deutschland GmbH, Potsdam, 14480, Germany|Nycomed Deutschland GmbH, Pottenstein, 91278, Germany|Nycomed Deutschland GmbH, Radebeul, 01445, Germany|Nycomed Deutschland GmbH, Radevormwald, 42477, Germany|Nycomed Deutschland GmbH, Rain, 86641, Germany|Nycomed Deutschland GmbH, Rathenow, 14712, Germany|Nycomed Deutschland GmbH, Ratingen, 40878, Germany|Nycomed Deutschland GmbH, Raubach, 56316, Germany|Nycomed Deutschland GmbH, Recke, 49509, Germany|Nycomed Deutschland GmbH, Recklinghausen, 45657, Germany|Nycomed Deutschland GmbH, Regensburg, 93055, Germany|Nycomed Deutschland GmbH, Reichenbach, 08468, Germany|Nycomed Deutschland GmbH, Reichenschwand, 91244, Germany|Nycomed Deutschland GmbH, Remscheid, 42853, Germany|Nycomed Deutschland GmbH, Remse, 08373, Germany|Nycomed Deutschland GmbH, Rendsburg, 24768, Germany|Nycomed Deutschland GmbH, Rheine, 48431, Germany|Nycomed Deutschland GmbH, Rhinow, 14728, Germany|Nycomed Deutschland GmbH, Riesa, 01591, Germany|Nycomed Deutschland GmbH, Rieschweiler-Mühlbach, 66509, Germany|Nycomed Deutschland GmbH, Rodenbach, 63517, Germany|Nycomed Deutschland GmbH, Rodenbach, 67688, Germany|Nycomed Deutschland GmbH, Roetgen, 52159, Germany|Nycomed Deutschland GmbH, Roggenburg, 89297, Germany|Nycomed Deutschland GmbH, Rosenfeld, 72348, Germany|Nycomed Deutschland GmbH, Rosengarten, 21224, Germany|Nycomed Deutschland GmbH, Rostock, 18055, Germany|Nycomed Deutschland GmbH, Rostock, 18059, Germany|Nycomed Deutschland GmbH, Rostock, 18109, Germany|Nycomed Deutschland GmbH, Roth, 91154, Germany|Nycomed Deutschland GmbH, Rottach-Egern, 83700, Germany|Nycomed Deutschland GmbH, Rudolstadt, 07407, Germany|Nycomed Deutschland GmbH, R?dermark, 63322, Germany|Nycomed Deutschland GmbH, Rüsselsheim, 65428, Germany|Nycomed Deutschland GmbH, Saalfeld/Saale, 07318, Germany|Nycomed Deutschland GmbH, Saal, 18317, Germany|Nycomed Deutschland GmbH, Saarbrücken, 66111, Germany|Nycomed Deutschland GmbH, Saarlouis, 66740, Germany|Nycomed Deutschland GmbH, Sachsenheim, 74343, Germany|Nycomed Deutschland GmbH, Salzmünde, 06198, Germany|Nycomed Deutschland GmbH, Schieder-Schwalenberg, 32816, Germany|Nycomed Deutschland GmbH, Schlo? Holte-Stukenbrock, 33758, Germany|Nycomed Deutschland GmbH, Schlüchtern, 36381, Germany|Nycomed Deutschland GmbH, Schm?lln, 04626, Germany|Nycomed Deutschland GmbH, Schrobenhausen, 86529, Germany|Nycomed Deutschland GmbH, Schwalbach, 66773, Germany|Nycomed Deutschland GmbH, Schwalmstadt, 34613, Germany|Nycomed Deutschland GmbH, Schwanewede, 28790, Germany|Nycomed Deutschland GmbH, Schwedt, 16303, Germany|Nycomed Deutschland GmbH, Schweinfurt, 97421, Germany|Nycomed Deutschland GmbH, Schwerin, 19053, Germany|Nycomed Deutschland GmbH, Schwerin, 19057, Germany|Nycomed Deutschland GmbH, Schwetzingen, 68723, Germany|Nycomed Deutschland GmbH, Schw?bisch Gmünd, 73525, Germany|Nycomed Deutschland GmbH, Sch?nberg, 24217, Germany|Nycomed Deutschland GmbH, Sch?nebeck, 39218, Germany|Nycomed Deutschland GmbH, Sebnitz, 01855, Germany|Nycomed Deutschland GmbH, Seelow, 15306, Germany|Nycomed Deutschland GmbH, Seevetal, 21217, Germany|Nycomed Deutschland GmbH, Seewald, 72297, Germany|Nycomed Deutschland GmbH, Sendenhorst, 48324, Germany|Nycomed Deutschland GmbH, Sickte, 38173, Germany|Nycomed Deutschland GmbH, Siegen, 57072, Germany|Nycomed Deutschland GmbH, Simmern, 55469, Germany|Nycomed Deutschland GmbH, Simmertal, 55618, Germany|Nycomed Deutschland GmbH, Sinntal, 36391, Germany|Nycomed Deutschland GmbH, Sinsheim, 74889, Germany|Nycomed Deutschland GmbH, Solingen, 42651, Germany|Nycomed Deutschland GmbH, Solingen, 42655, Germany|Nycomed Deutschland GmbH, Solingen, 42657, Germany|Nycomed Deutschland GmbH, Solingen, 42697, Germany|Nycomed Deutschland GmbH, Solingen, 42699, Germany|Nycomed Deutschland GmbH, Soltau, 29614, Germany|Nycomed Deutschland GmbH, Sonneberg, 96515, Germany|Nycomed Deutschland GmbH, Speyer, 67346, Germany|Nycomed Deutschland GmbH, Sprockh?vel, 45549, Germany|Nycomed Deutschland GmbH, St. Blasien, 79837, Germany|Nycomed Deutschland GmbH, Stadtallendorf, 35260, Germany|Nycomed Deutschland GmbH, Stadthagen, 31655, Germany|Nycomed Deutschland GmbH, Staig, 89195, Germany|Nycomed Deutschland GmbH, Steimel, 57614, Germany|Nycomed Deutschland GmbH, Steinbach, 61449, Germany|Nycomed Deutschland GmbH, Steinfeld, 49439, Germany|Nycomed Deutschland GmbH, Steinhagen, 33803, Germany|Nycomed Deutschland GmbH, Stockach, 78333, Germany|Nycomed Deutschland GmbH, Straelen, 47638, Germany|Nycomed Deutschland GmbH, Stralsund, 18437, Germany|Nycomed Deutschland GmbH, Straupitz, 15913, Germany|Nycomed Deutschland GmbH, Strausberg, 15344, Germany|Nycomed Deutschland GmbH, Stuhr, 28816, Germany|Nycomed Deutschland GmbH, Stuttgart, 70173, Germany|Nycomed Deutschland GmbH, Stuttgart, 70191, Germany|Nycomed Deutschland GmbH, Stuttgart, 70372, Germany|Nycomed Deutschland GmbH, Stuttgart, 70435, Germany|Nycomed Deutschland GmbH, Stuttgart, 70565, Germany|Nycomed Deutschland GmbH, Sulz, 72172, Germany|Nycomed Deutschland GmbH, Sundern, 59846, Germany|Nycomed Deutschland GmbH, S?mmerda, 99610, Germany|Nycomed Deutschland GmbH, Sü?en, 73079, Germany|Nycomed Deutschland GmbH, Tangermünde, 39590, Germany|Nycomed Deutschland GmbH, Teltow, 14513, Germany|Nycomed Deutschland GmbH, Teterow, 17166, Germany|Nycomed Deutschland GmbH, Teuchern, 06682, Germany|Nycomed Deutschland GmbH, Teutschenthal, 06179, Germany|Nycomed Deutschland GmbH, Thurnau, 95349, Germany|Nycomed Deutschland GmbH, Tirschenreuth, 95643, Germany|Nycomed Deutschland GmbH, Tuttlingen, 78532, Germany|Nycomed Deutschland GmbH, Uchte, 31600, Germany|Nycomed Deutschland GmbH, Ueckermünde, 17373, Germany|Nycomed Deutschland GmbH, Ulm, 89073, Germany|Nycomed Deutschland GmbH, Unna, 59423, Germany|Nycomed Deutschland GmbH, Urbach, 56317, Germany|Nycomed Deutschland GmbH, Uttenreuth, 91080, Germany|Nycomed Deutschland GmbH, Vaihingen, 71665, Germany|Nycomed Deutschland GmbH, Viersen, 41751, Germany|Nycomed Deutschland GmbH, Villingen-Schwenningen, 78050, Germany|Nycomed Deutschland GmbH, Vilshofen, 94474, Germany|Nycomed Deutschland GmbH, Voerde, 46562, Germany|Nycomed Deutschland GmbH, Waiblingen, 71332, Germany|Nycomed Deutschland GmbH, Wandlitz, 16348, Germany|Nycomed Deutschland GmbH, Waren (Müritz), 17192, Germany|Nycomed Deutschland GmbH, Weidenberg, 95446, Germany|Nycomed Deutschland GmbH, Weilheim, 82362, Germany|Nycomed Deutschland GmbH, Wei?enfels, 06667, Germany|Nycomed Deutschland GmbH, Wei?wasser, 02943, Germany|Nycomed Deutschland GmbH, Werder, 14542, Germany|Nycomed Deutschland GmbH, Wetter, 35083, Germany|Nycomed Deutschland GmbH, Wiesbaden, 65183, Germany|Nycomed Deutschland GmbH, Wiesloch, 69168, Germany|Nycomed Deutschland GmbH, Wilhermsdorf, 91452, Germany|Nycomed Deutschland GmbH, Wilster, 25554, Germany|Nycomed Deutschland GmbH, Winh?ring, 84543, Germany|Nycomed Deutschland GmbH, Wissen, 57537, Germany|Nycomed Deutschland GmbH, Witten, 58452, Germany|Nycomed Deutschland GmbH, Wittislingen, 89426, Germany|Nycomed Deutschland GmbH, Wittstock, 16909, Germany|Nycomed Deutschland GmbH, Wolfsburg, 38440, Germany|Nycomed Deutschland GmbH, Wolfsburg, 38446, Germany|Nycomed Deutschland GmbH, Wolfschlugen, 72649, Germany|Nycomed Deutschland GmbH, Wolgast, 17438, Germany|Nycomed Deutschland GmbH, Wulfen, 06369, Germany|Nycomed Deutschland GmbH, Wyhl, 79369, Germany|Nycomed Deutschland GmbH, W?llstein, 55597, Germany|Nycomed Deutschland GmbH, W?rth, 76744, Germany|Nycomed Deutschland GmbH, Würzburg, 97070, Germany|Nycomed Deutschland GmbH, Xanten, 46509, Germany|Nycomed Deutschland GmbH, Zeitz, 06712, Germany|Nycomed Deutschland GmbH, Zellingen, 97225, Germany|Nycomed Deutschland GmbH, Zerbst, 39261, Germany|Nycomed Deutschland GmbH, Zossen, 15806, Germany|Nycomed Deutschland GmbH, Zwickau, 08066, Germany|Nycomed Deutschland GmbH, Zühlsdorf, 16515, Germany|Nycomed Deutschland GmbH, überlingen, 88662, Germany Less <<
NCT00246922 Bronchial Asthma PHASE3 COMPLETED 2025-10-07 Nycomed Japan and Mitsubishi T... More >>anabe Pharma Corporation, Osaka, Japan Less <<
NCT00062582 Chronic Obstructive Pulmonary ... More >>Disease|COPD Less << PHASE3 COMPLETED - ALTANA Pharma, Cities in Alaba... More >>ma, Alabama, United States|ALTANA Pharma, Cities in Arizona, Arizona, United States|ALTANA Pharma, Cities in California, California, United States|ATLANA Pharma, Cities in Colorado, Colorado, United States|ALTANA Pharma, Cities in Conneticut, Connecticut, United States|ALTANA Pharma, Cities in Delaware, Delaware, United States|ALTANA Pharma, Cities in Florida, Florida, United States|ALTANA Pharma, Cities in Georgia, Georgia, United States|ALTANA Pharma, Cities in Idaho, Idaho, United States|ALTANA Pharma, Cities in Indiana, Indiana, United States|ALTANA Pharma, Cities in Iowa, Iowa, United States|ALTANA Pharma, Cities in Kansas, Kansas, United States|ALTANA Pharma, Cities in Kentucky, Kentucky, United States|ALTANA Pharma, Cities in Louisiana, Louisiana, United States|ALTANA Pharma, Cities in Maryland, Maryland, United States|ALTANA Pharma, Cities in Michigan, Michigan, United States|ALTANA Pharma, Cities in Missouri, Missouri, United States|ALTANA Pharma, Cities in Nebraska, Nebraska, United States|ALTANA Pharma, Cities in Nevada, Nevada, United States|ALTANA Pharma, Cities in New Jersey, New Jersey, United States|ALTANA Pharma, Cities in New York, New York, United States|ALTANA Pharma, Cities in North Carolina, North Carolina, United States|ALTANA Pharma, Cities in Ohio, Ohio, United States|ALTANA Pharma, Cities in Oregon, Oregon, United States|ALTANA Pharma, Cities in Pennsylvania, Pennsylvania, United States|ALTANA Pharma, Cities in Rhode Island, Rhode Island, United States|ALTANA Pharma, Cities in South Carolina, South Carolina, United States|ALTANA Pharma, Cities in Texas, Texas, United States|ALTANA Pharma, Cities in Utah, Utah, United States|ALTANA Pharma, Cities in Virginia, Virginia, United States|ALTANA Pharma, Cities in Washington, Washington, United States|ALTANA Pharma, Cities in West Virginia, West Virginia, United States|ALTANA Pharma, Cities in Argentina, Argentina|ALTANA Pharma, Cities in Canada, Canada|ALTANA Pharma, Cities in Colombia, Colombia|ALTANA Pharma, Cities in Mexico, Mexico|ALTANA Pharma, Cities in Peru, Peru Less <<
NCT00246935 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << PHASE3 COMPLETED 2025-10-07 Nycomed in Japan and Mitsubish... More >>i Tanabe Pharma Corporation, Osaka, Japan Less <<
NCT02187926 - Completed - -
NCT00242307 Bronchial Asthma PHASE2|PHASE3 COMPLETED 2025-06-07 Nycomed Japan and Mitsubishi T... More >>anabe Pharma Corporation, Osaka, Japan Less <<
NCT00073177 Asthma PHASE3 COMPLETED - ALTANA Pharma, Cities in Alaba... More >>ma, Alabama, United States|ALTANA Pharma, Cities in Arizona, Arizona, United States|ALTANA Pharma, Cities in Arkansas, Arkansas, United States|ALTANA Pharma, Cities in California, California, United States|ALTANA Pharma, Cities in Colorado, Colorado, United States|ALTANA Pharma, Cities in Florida, Florida, United States|ALTANA Pharma, Cities in Georgia, Georgia, United States|ALTANA Pharma, Cities in Idaho, Idaho, United States|ALTANA Pharma, Cities in Illinois, Illinois, United States|ALTANA Pharma, Cities in Indiana, Indiana, United States|ALTANA Pharma, Cities in Iowa, Iowa, United States|ALTANA Pharma, Cities in Kansas, Kansas, United States|ALTANA Pharma, Cities in Kentucky, Kentucky, United States|ALTANA Pharma, Cities in Louisiana, Louisiana, United States|ALTANA Pharma, Cities in Maryland, Maryland, United States|ALTANA Pharma, Massachusetts, Massachusetts, United States|ALTANA Pharma, Cities in Michigan, Michigan, United States|ALTANA Pharma, Cities in Minnesota, Minnesota, United States|ALTANA Pharma, Cities in Mississippi, Mississippi, United States|ALTANA Pharma, Cities in Missouri, Missouri, United States|ALTANA Pharma, Cities in Montana, Montana, United States|ALTANA Pharma, Cities in Nebraska, Nebraska, United States|ALTANA Pharma, Cities in Nevada, Nevada, United States|ALTANA Pharma, Cities in New Jersey, New Jersey, United States|ALTANA Pharma, Cities in New York, New York, United States|ALTANA Pharma, Cities in North Carolina, North Carolina, United States|ALTANA Pharma, Cities in North Dakota, North Dakota, United States|ALTANA Pharma, Cities in Oregon, Oregon, United States|ALTANA Pharma, Cities in Pennsylvania, Pennsylvania, United States|ALTANA Pharma, Cities in Rhode Island, Rhode Island, United States|ALTANA Pharma, Cities in South Carolina, South Carolina, United States|ALTANA Pharma, Cities in Tennessee, Tennessee, United States|ALTANA Pharma, Cities in Texas, Texas, United States|ALTANA Pharma, Cities in Utah, Utah, United States|ALTANA Pharma, Cities in Virginia, Virginia, United States|ALTANA Pharma, Cities in Washington, Washington, United States|ALTANA Pharma, Cities in Wisconsin, Wisconsin, United States|ALTANA Pharma, Cities in Argentina, Argentina|ALTANA Pharma, Cities in Colombia, Colombia|ALTANA Pharma, Cities in Mexico, Mexico|ALTANA Pharma, Cities in Peru, Peru Less <<
NCT00076076 Asthma PHASE3 COMPLETED 2025-06-05 ALTANA Pharma, Cities in Alaba... More >>ma, Alabama, United States|ALTANA Pharma, Cities in Arizona, Arizona, United States|ALTANA Pharma, Cities in Arkansas, Arkansas, United States|ALTANA Pharma, Cities in California, California, United States|ALTANA Pharma, Cities in Colorado, Colorado, United States|ALTANA Pharma, Cities in Connecticut, Connecticut, United States|ALTANA Pharma, Cities in Delaware, Delaware, United States|ALTANA Pharma, Cities in Florida, Florida, United States|ALTANA Pharma, Cities in Georgia, Georgia, United States|ALTANA Pharma, Cities in Illinois, Illinois, United States|ALTANA Pharma, Cities in Indiana, Indiana, United States|ALTANA Pharma, Cities in Kansas, Kansas, United States|ALTANA Pharma, Cities in Kentucky, Kentucky, United States|ALTANA Pharma, Cities in Louisiana, Louisiana, United States|ALTANA Pharma, Cities in Maine, Maine, United States|ALTANA Pharma, Cities in Maryland, Maryland, United States|ALTANA Pharma, Cities in Massachusetts, Massachusetts, United States|ALTANA Pharma, Cities in Michigan, Michigan, United States|ALTANA Pharma, Cities in Minnesota, Minnesota, United States|ALTANA Pharma, Cities in Missouri, Missouri, United States|ALTANA Pharma, Cities in Montana, Montana, United States|ALTANA Pharma, Cities in Nebraska, Nebraska, United States|ALTANA Pharma, Cities in Nevada, Nevada, United States|ALTANA Pharma, Cities in New Jersey, New Jersey, United States|ALTANA Pharma, Cities in New York, New York, United States|ALTANA Pharma, Cities in North Carolina, North Carolina, United States|ALTANA Pharma, Cities in Ohio, Ohio, United States|ALTANA Pharma, Cities in Oklahoma, Oklahoma, United States|ALTANA Pharma, Cities in Oregon, Oregon, United States|ALTANA Pharma, Cities in Pennsylvania, Pennsylvania, United States|ALTANA Pharma, Cities in Rhode Island, Rhode Island, United States|ALTANA Pharma, Cities in South Carolina, South Carolina, United States|ALTANA Pharma, Cities in Tennessee, Tennessee, United States|ALTANA Pharma, Cities in Texas, Texas, United States|ALTANA Pharma, Cities in Utah, Utah, United States|ALTANA Pharma, Cities in Vermont, Vermont, United States|ALTANA Pharma, Cities in Virginia, Virginia, United States|ALTANA Pharma, Cities in Washington, Washington, United States|ALTANA Pharma, Cities in West Virginia, West Virginia, United States|ALTANA Pharma, Cities in Russia, Russian Federation|ALTANA Pharma, Cities in the Ukraine, Ukraine Less <<
NCT00076089 Chronic Obstructive Pulmonary ... More >>Disease|COPD Less << PHASE3 COMPLETED 2025-12-05 ALTANA Pharma, Cities in Alaba... More >>ma, Alabama, United States|ALTANA Pharma, Cities in Arizona, Arizona, United States|ALTANA Pharma, Cities in Arkansas, Arkansas, United States|ALTANA Pharma, Cities in California, California, United States|ALTANA Pharma, Cities in Colorado, Colorado, United States|ALTANA Pharma, Cities in Connecticut, Connecticut, United States|ALTANA Pharma, Cities in Florida, Florida, United States|ALTANA Pharma, Cities in Georgia, Georgia, United States|ALTANA Pharma, Cities in Illionois, Illinois, United States|ALTANA Pharma, Cities in Iowa, Iowa, United States|ALTANA Pharma, Cities in Kentucky, Kentucky, United States|ALTANA Pharma, Cities in Louisiana, Louisiana, United States|ALTANA Pharma, Cities in Massachusetts, Massachusetts, United States|ALTANA Pharma, Cities in Minnesota, Minnesota, United States|ALTANA Pharma, Cities in Missouri, Missouri, United States|ALTANA Pharma, Cities in Montana, Montana, United States|ALTANA Pharma, Cities in Nebraska, Nebraska, United States|ALTANA Pharma, Cities in Nevada, Nevada, United States|ALTANA Pharma, Cities in New Hampshire, New Hampshire, United States|ALTANA Pharma, Cities in New Jersey, New Jersey, United States|ALTANA Pharma, Cities in New York, New York, United States|ALTANA Pharma, Cities in North Carolina, North Carolina, United States|ALTANA Pharma, Cities in Ohio, Ohio, United States|ALTANA Pharma, Cities in Oklahoma, Oklahoma, United States|ALTANA Pharma, Cities in Oregon, Oregon, United States|ALTANA Pharma, Cities in Pennsylvania, Pennsylvania, United States|ALTANA Pharma, Cities in Rhode Island, Rhode Island, United States|ALTANA Pharma, Cities in South Carolina, South Carolina, United States|ALTANA Pharma, Cities in Tennessee, Tennessee, United States|ALTANA Pharma, Cities in Texas, Texas, United States|ALTANA Pharma, Cities in Utah, Utah, United States|ALTANA Pharma, Cities in Vermont, Vermont, United States|ALTANA Pharma, Cities in Virginia, Virginia, United States|ALTANA Pharma, Cities in West Virginia, West Virginia, United States|ALTANA Pharma, Cities in Wisconsin, Wisconsin, United States|ALTANA Pharma, Cities in Canada, Canada|ALTANA Pharma, Cities in France, France|ALTANA Pharma, Cities in Germany, Germany|ALTANA Pharma, Cities in Poland, Poland|ALTANA Pharma, Cities in South Africa, South Africa Less <<
NCT02051335 Memory Impairment ... More >> Alzheimer's Disease Less << Phase 1 Completed - United Kingdom ... More >> London, United Kingdom Less <<
NCT00163475 Asthma PHASE3 COMPLETED 2025-08-05 ALTANA Pharma, Cities in Austr... More >>alia, Australia|ALTANA Pharma, Cities in Belgium, Belgium|ALTANA Pharma, Cities in France, France|ALTANA Pharma, Cities in South Africa, South Africa|ALTANA Pharma, Cities in Spain, Spain Less <<
NCT02671942 Chronic Obstructive Pulmonary ... More >>Disease Less << Phase 2 Recruiting December 2017 China, Guangdong ... More >> First Affiliated Hospital of Guangzhou Medical University Recruiting Guangzhou, Guangdong, China, 510120 Contact: Zheng jinping ?? 18928868238 ?? 18928868238@163.com Less <<
NCT00163527 Asthma PHASE3 COMPLETED 2025-11-05 ALTANA Pharma, Cities in Georg... More >>ia, Georgia, United States|ALTANA Pharma, Cities in Austria, Austria|ALTANA Pharma, Cities in Croatia, Croatia|ALTANA Pharma, Cities in the Czech Repulik, Czech Republic|ALTANA Pharma, Cities in Finland, Finland|ALTANA Pharma, Cities in France, France|ALTANA Pharma, Cities in Greece, Greece|ALTANA Pharma, Cities in Hungary, Hungary|ALTANA Pharma, Cities in India, India|ALTANA Pharma, Cities in Ireland, Ireland|ALTANA Pharma, Cities in Italy, Italy|ALTANA Pharma, Cities in New Zealand, New Zealand|ALTANA Pharma, Cities in Norway, Norway|ALTANA Pharma, Cities in Pakistan, Pakistan|ALTANA Pharma, Cities in the Philippines, Philippines|ALTANA Pharma, Cities in Poland, Poland|ALTANA Pharma, Cities in Portugal, Portugal|ALTANA Pharma, Cities in the Russian Federation, Russian Federation|ALTANA Pharma, Sites in Singapore, Singapore|ALTANA Pharma, Cities in South Africa, South Africa|ALTANA Pharma, Cities in Spain, Spain|ALTANA Pharma, Cities in Taiwan, Taiwan|ALTANA Pharma, Cities in Thailand, Thailand|ALTANA Pharma, Cities in the United Kindom, United Kingdom Less <<
NCT00297102 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Phase 3 Completed - -
NCT00297115 - Completed - -
NCT02015767 - Completed - -
NCT00940329 Healthy Phase 1 Completed - Germany ... More >> Nycomed Konstanz, Germany, 78467 Less <<
NCT00297102 - Completed - -
NCT00297115 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Phase 3 Completed - -
NCT01509677 COPD Chronic ... More >>Obstructive Pulmonary Disease Less << Phase 3 Completed - Denmark ... More >> Kobenhavn NV, Denmark K?benhavn NV, Denmark, DK-2400 Germany Freiburg, Germany Grosshansdorf, Germany Hannover, Germany Heidelberg, Germany Immenhausen, Germany Kiel, Germany Mainz, Germany Poland Bialystok, Poland Krakow, Poland Lodz, Poland, 90-153 Lodz, Poland Sweden Lund, Sweden United Kingdom Cottingham, United Kingdom Dafen, United Kingdom Leicester, United Kingdom London, United Kingdom Manchester, United Kingdom Norwich, United Kingdom, NR4 7UY Less <<
NCT01664624 - Completed - -
NCT00242320 COPD Phase 3 Completed - Hong Kong ... More >> Altana Pharma/Nycomed Hong Kong, Hong Kong, 852 Altana Pharma/Nycomed Shatin, NT, Hong Kong, Hong Kong Korea, Republic of Altana Pharma/Nycomed Anvang-Si, Gveonggi-Do, Korea, Republic of, 431-070 Altana Pharma/Nycomed Chungbuk, Korea, Republic of, 361-711 Altana Pharma/Nycomed Gangwon-do, Korea, Republic of, 220-701 Altana Pharma/Nycomed Gangwon-Do, Korea, Republic of, 220-711 Altana Pharma/Nycomed Gwangju, Korea, Republic of, 501-757 Altana Pharma/Nycomed Gyeonggi-do, Korea, Republic of, 420-767 Altana Pharma/Nycomed Jiniu-Si. Gveongsangnam-Do, Korea, Republic of, 660-702 Altana Pharma/Nycomed Seoul, Korea, Republic of, 135-720 Altana Pharma/Nycomed Seoul, Korea, Republic of, 136-705 Altana Pharma/Nycomed Seoul, Korea, Republic of, 137-701 Altana Pharma/Nycomed Seoul, Korea, Republic of, 138-736 Altana Pharma/Nycomed Seoul, Korea, Republic of, 140-757 Altana Pharma/Nycomed Seoul, Korea, Republic of, 158-710 Altana Pharma/Nycomed Uijongbu-city, Gveonggi-Do, Korea, Republic of, 480-130 Altana Pharma/Nycomed Ulsan, Korea, Republic of, 682-060 Malaysia Altana Pharma/Nycomed Jalan Rasah, Seremban, Malaysia, 70300 Altana Pharma/Nycomed Kota Bharu / Kelantan, Malaysia, 16150 Altana Pharma/Nycomed Kota Kinabalu, Sabah, Malaysia, 88586 Altana Pharma/Nycomed Kuala Lumpur, Malaysia, 50590 Altana Pharma/Nycomed Kuala Lumpur, Malaysia, 56000 Altana Pharma/Nycomed Kuala Lumpur, Malaysia, 59100 Philippines Altana Pharma/Nycomed Manila, Philippines, 1000 Altana Pharma/Nycomed Quezon City, Philippines, 1100 Altana Pharma/Nycomed Quezon City, Philippines, 1102 Altana Pharma/Nycomed Quezon City, Philippines, 850 Altana Pharma/Nycomed Quezon City, Philippines, 870 Taiwan Altana Pharma/Nycomed Kaohsiung, Taiwan, 886-807 Altana Pharma/Nycomed Taipei City 114, Taiwan, 886-114 Altana Pharma/Nycomed Taipei, Taiwan, 886-114 Altana Pharma/Nycomed Taipei, Taiwan Altana Pharma/Nycomed Tau-Yuan, Taiwan, 886-333 Less <<
NCT00313209 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Phase 3 Completed - -
NCT00430729 Chronic Obstructive Pulmonary ... More >>Disease|COPD Less << PHASE3 COMPLETED - ALTANA Pharma, Cities in Austr... More >>alia, Australia|ALTANA Pharma, Cities in Austria, Austria|ALTANA Pharma, Cities in Canada, Canada|ALTANA Pharma, Cities in France, France|ALTANA Pharma, Cities in Hungary, Hungary|ALTANA Pharma, Cities in Italy, Italy|ALTANA Pharma, Cities in the Netherlands, Netherlands|ALTANA Pharma, Cities in Poland, Poland|ALTANA Pharma, Cities in Portugal, Portugal|ALTANA Pharma, Cities in the Russian Federation, Russian Federation|ALTANA Pharma, Cities in South Africa, South Africa|ALTANA Pharma, Cities in Spain, Spain|ALTANA Pharma, Cities in Switzerland, Switzerland|ALTANA Pharma, Cities in the United Kingdom, United Kingdom Less <<
NCT02051335 - Completed - -
NCT00746434 Plaque Psoriasis Phase 2 Withdrawn(Study withdrawn due ... More >>to business decisions. No subjects were treated.) Less << September 2009 -
NCT01473758 Chronic Obstructive Pulmonary ... More >>Disease With (Acute) Exacerbation Less << Phase 2 Terminated(Company decision No... More >> Safety or Efficacy Concerns) Less << - United Kingdom ... More >> Academic Unit of Respiratory Medicine, Royal Free Hospital, Jadwiga A. Wedzicha London, United Kingdom, NW3 2PF London, United Kingdom Less <<
NCT00313209 - Completed - -
NCT01433666 Dementia Phase 2 Completed - Netherlands ... More >> Maastricht University, Faculty of Psychology and Neuroscience Maastricht, Limburg, Netherlands, 6200 MD Less <<
NCT01313494 COPD Phase 3 Completed - China ... More >> Beijing, China Changsha, China Chengdu, China Chongqing, China Fuzhou, China Guangzhou, China Hangzhou, China Nanjing, China Nanning, China Qingdao, China Shanghai, China Shenyang, China Shijiazhuang, China Hong Kong Hong Kong, Hong Kong Singapore Singapore, Singapore Less <<
NCT01140542 Diabetes Mellitus Type 2 PHASE2 COMPLETED 2025-03-08 -
NCT01480661 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 4 Completed - Belgium ... More >> Antwerp University Hospital Edegem, Antwerp, Belgium, 2650 ZNA Middelheim Antwerp, Belgium, 2020 Less <<
NCT00424268 Chronic Obstructive Pulmonary ... More >>Disease Less << Phase 3 Completed - -
NCT01473758 - Terminated(Company decision No... More >> Safety or Efficacy Concerns) Less << - -
NCT01329029 Chronic Obstructive Pulmonary ... More >>Disease Less << Phase 4 Completed - -
NCT01664624 Type 2 Diabetes Phase 1 Completed - United States, California ... More >> Chula Vista, California, United States United States, Florida Orlando, Florida, United States Less <<
NCT00746382 Dermatitis Phase 2 Withdrawn(Study withdrawn due ... More >>to business decisions. No subjects were treated.) Less << September 2009 -
NCT01703260 Nonalcoholic Steatohapatitis Phase 2 Terminated(Company decision; N... More >>o safety or efficacy concerns (see detailed description)) Less << - United States, California ... More >> Coronado, California, United States, 92118 Coronado, California, United States United States, Maryland Annapolis, Maryland, United States, 21401 Baltimore, Maryland, United States, 21202 Less <<
NCT01595750 Chronic Obstructive Pulmonary ... More >>Disease Less << Phase 4 Unknown August 2012 Spain ... More >> Spanish Research Center for Respiratory Diseases Not yet recruiting Bunyola, Balearic Island, Spain, 07110 Contact: Paloma Vaquer ?? 0034971011772 ?? pvaquer@ciberes.org Less <<
NCT01329029 - Completed - -
NCT00424268 - Completed - -
NCT01856764 - Completed - -
NCT02187250 PCOS Obesity Phase 4 Completed - Slovenia ... More >> University Medical Center Ljubljana Ljubljana, Slovenia, 1000 Less <<
NCT01313494 - Completed - -
NCT01856764 Atopic Dermatitis Phase 2 Completed - Germany ... More >> Berlin, Germany Gera, Germany Hamburg, Germany Less <<
NCT01701934 Chronic Obstructive Pulmonary ... More >>Disease Metabolic Syndrome Less << Phase 2 Terminated(The recruitment of ... More >>the study was prematurely stopped in July 2014 for the following reason; no more study medication.) Less << December 2014 Canada, British Columbia ... More >> St. Paul's Hospital Vancouver, British Columbia, Canada, V6Z 1Y6 Canada, Quebec Centre hospitalier de l'Université de Montréal Montréal, Quebec, Canada, H2W 1T8 Montreal Chest Institute Montréal, Quebec, Canada, H2X 2P4 Institut universitaire de cardiologie et de pneumologie de Québec Québec, Quebec, Canada, G1V 4G5 H?pital régional de Saint-Jér?me Saint-Jér?me, Quebec, Canada, J7Z 5T3 Less <<
NCT01572948 COPD Not Applicable Completed - United States, Alabama ... More >> UAB Lung Health Center Birmingham, Alabama, United States, 35294 Less <<
NCT01703260 - Terminated(Company decision; N... More >>o safety or efficacy concerns (see detailed description)) Less << - -
NCT01888952 Advanced B-cell Lymphoid Malig... More >>nancies Less << Early Phase 1 Completed - United States, Texas ... More >> Ctrc @ Uthscsa San Antonio, Texas, United States, 78229 Less <<
NCT01572948 - Completed - -
NCT01888952 - Completed - -
NCT01973998 COPD Phase 3 Completed - United States, Pennsylvania ... More >> Temple University Hospital Philadelphia, Pennsylvania, United States, 19140 Less <<
NCT02097992 - Completed - -
NCT02079844 Schizophrenia Phase 1 Completed - United Kingdom ... More >> Denmark Hill, London, United Kingdom Less <<
NCT02037672 PCOS Obesity Phase 4 Completed - Slovenia ... More >> University Medical Center Ljubljana Ljubljana, Slovenia, 1000 Less <<
NCT01443845 COPD COPD Exa... More >>cerbation Lung Diseases Respiratory Disorders Pulmonary Disease Chronic Obstructive Lung Diseases Chronic Obstructive Airway Disease Less << Phase 4 Completed - -
NCT01765192 Asthma Phase 2 Completed - Germany ... More >> Berlin, Germany Grosshansdorf, Germany Hamburg, Germany Hannover, Germany Mainz, Germany Schwerin, Germany Hungary Budapest, Hungary Nyiregyhaza, Hungary Szarvas, Hungary Torokbalint, Hungary South Africa Bloemfontein, South Africa Cape Town, South Africa Pretoria, South Africa Less <<
NCT03073798 - Completed - -
NCT01765192 - Completed - -
NCT02079844 - Completed - -
NCT02451540 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 2 Terminated(No new investigatio... More >>nal product can be delivered to the site.) Less << - Belgium ... More >> University Hospital of Antwerp Edegem, Antwerp, Belgium, 2650 Less <<
NCT01630200 Chronic Obstructive Pulmonary ... More >>Disease and Allied Conditions Less << Phase 2 Unknown January 2016 Austria ... More >> Deparment for Respiratory and Critical Care Medicine, Otto Wangner Hospital Vienna, Austria, 1140 Less <<
NCT01443845 - Completed - -
NCT03073798 COPD Chronic ... More >>Bronchitis Emphysema Less << Phase 4 Completed - -
NCT03458546 Lymphoma, B-Cell PHASE1 COMPLETED 2024-01-16 Mays Cancer Center, UT Health ... More >>San Antonio, San Antonio, Texas, 78229, United States Less <<
NCT01365533 Allergic Asthma Phase 2 Completed - Canada ... More >> Nycomed investigational site Quebec, Canada Less <<
NCT02165826 - Completed - -
NCT01830959 Sarcoidosis Phase 4 Unknown October 2016 United States, Ohio ... More >> University of Cincinnati Cincinnati, Ohio, United States, 45267 Less <<
NCT02097992 COPD Phase 1 Phase 2 Completed - United States, Florida ... More >> University of Miami Divison of Pulmonary and Critical Care Medicine Miami, Florida, United States, 33136 Less <<
NCT01862029 Obesity PHASE1|PHASE2 COMPLETED 2017-07-25 National Institutes of Health ... More >>Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States Less <<
NCT02165826 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Phase 3 Completed - Slovakia ... More >> Bardejov, Slovakia Spisska Nova Ves, Slovakia Less <<
NCT01862029 Obesity PHASE1|PHASE2 COMPLETED 2017-07-25 National Institutes of Health ... More >>Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States Less <<
NCT02068456 Chronic Obstructive Pulmonary ... More >>Disease Less << COMPLETED 2017-04-26 Seoul, Korea, Republic of
NCT01354782 Chronic Obstructive Pulmonary ... More >>Disease Less << PHASE1 COMPLETED 2025-09-11 Nycomed Investigational Site, ... More >>Beijing, 100032, China Less <<
NCT01849341 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Phase 4 Completed - Spain ... More >> Hospital de Jerez Jerez de la Frontera, Cádiz, Spain Hospital Universitario Reina Sofía Córdoba, Spain H.U. Virgen de las Nieves Granada, Spain Hospital Universitario Virgen Macarena Sevilla, Spain Less <<
NCT01745848 Chronic Obstructive Pulmonary ... More >>Disease Less << PHASE4 COMPLETED 2016-06-30 Emphysema COPD Research Center... More >>, Pittsburgh, Pennsylvania, 15213, United States Less <<
NCT02018432 Chronic Obstructive Pulmonary ... More >>Disease Less << Phase 4 Unknown December 2015 Korea, Republic of ... More >> Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine Not yet recruiting Seoul, Korea, Republic of, 138-736 Contact: Sei Won Lee, MD ?? +82-3010-3990 ?? iseiwon@gmail.com Less <<
NCT01745848 Chronic Obstructive Pulmonary ... More >>Disease Less << PHASE4 COMPLETED 2016-06-30 Emphysema COPD Research Center... More >>, Pittsburgh, Pennsylvania, 15213, United States Less <<
NCT03428334 Non-cystic Fibrosis Bronchiect... More >>asis Less << Phase 2 Recruiting August 31, 2019 Hong Kong ... More >> Queen Mary Hospital Recruiting Hong Kong, Hong Kong Contact: James CM Ho, MD Less <<
NCT03381573 COPD COMPLETED 2022-09-16 Research Site, Cambridge, Mass... More >>achusetts, 02139, United States|Research Site, Bremen, Germany|Research Site, Oslo, 0483, Norway|Research Site, Solna, Sweden Less <<
NCT03532490 Asthma Obesit... More >>y Less << Phase 2 Recruiting April 2020 United States, Arizona ... More >> University of Arizona Active, not recruiting Tucson, Arizona, United States, 85724 United States, Illinois Northwestern University Feinberg School of Medicine Active, not recruiting Chicago, Illinois, United States, 60611 United States, New York Mount Sinai Icahn School of Medicine Active, not recruiting New York, New York, United States, 10029 United States, North Carolina Duke University Recruiting Durham, North Carolina, United States, 27705 Contact: Cathy Foss, BS ?? 919-479-0861 ?? catherine.foss@duke.edu ?? United States, Vermont University of Vermont Recruiting Colchester, Vermont, United States, 05446 Contact: Kathy Meehan ?? 802-847-8839 ?? kathy.meehan@uvmhealth.org Less <<
NCT04090294 Bronchiectasis EARLY_PHASE1 UNKNOWN 2025-11-20 -
NCT03764475 Plaque Psoriasis PHASE2 COMPLETED 2020-10-08 Arcutis Clinical Site 35, Beve... More >>rly Hills, California, 90212, United States|Arcutis Clinical Site 29, Northridge, California, 91324, United States|Arcutis Clinical Site 28, San Diego, California, 92123, United States|Arcutis Clinical Site 27, Santa Monica, California, 90403, United States|Arcutis Clinical Site 12, Miami, Florida, 33144, United States|Arcutis Clinical Site 16, Sanford, Florida, 32771, United States|Arcutis Clinical Site 21, Louisville, Kentucky, 40217, United States|Arcutis Clinical Site 34, Clinton Township, Michigan, 48038, United States|Arcutis Clinical Site 33, Detroit, Michigan, 48202, United States|Arcutis Clinical Site 20, Fridley, Minnesota, 55432, United States|Arcutis Clinical Site 22, New York, New York, 10029, United States|Arcutis Clinical Site 14, High Point, North Carolina, 27262, United States|Arcutis Clinical Site 39, Bexley, Ohio, 43209, United States|Arcutis Clinical Site 15, Pittsburgh, Pennsylvania, 15213, United States|Arcutis Clinical Site 19, College Station, Texas, 77845, United States|Arcutis Clinical Site 37, Houston, Texas, 77004, United States|Arcutis Clinical Site 13, Houston, Texas, 77056, United States|Arcutis Clinical Site 23, San Antonio, Texas, 78213, United States|Arcutis Clinical Site 24, Webster, Texas, 77598, United States|Arcutis Clinical Site 31, Norfolk, Virginia, 23502, United States|Arcutis Clinical Site 18, Surrey, British Columbia, V3R 6A7, Canada|Arcutis Clinical Site 11, Surrey, British Columbia, V3V 0C6, Canada|Arcutis Clinical Site 38, Winnipeg, Manitoba, R3M 3Z4, Canada|Arcutis Clinical Site 10, Ajax, Ontario, L1S 7K8, Canada|Arcutis Clinical Site 25, London, Ontario, N6H 5L5, Canada|Arcutis Clinical Site 26, Markham, Ontario, L3P 1X2, Canada|Arcutis Clinical Site 32, Oakville, Ontario, L6J 7W5, Canada|Arcutis Clinical Site 17, Peterborough, Ontario, K9J 5K2, Canada|Arcutis Clinical Site 30, Waterloo, Ontario, N2J 1C4, Canada|Arcutis Clinical Site 36, Windsor, Ontario, N8W 1E6, Canada Less <<
NCT04549870 Psoriasis PHASE2 COMPLETED 2022-12-12 Bispebjerg Hospital, Copenhage... More >>n, Denmark Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.48mL

0.50mL

0.25mL

12.40mL

2.48mL

1.24mL

24.80mL

4.96mL

2.48mL

References

[1]Martorana PA, Lunghi B, et al. Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice. BMC Pulm Med. 2008 Aug 28;8:17.

[2]Hatzelmann A, Schudt C. Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. J Pharmacol Exp Ther. 2001 Apr;297(1):267-79.

[3]Wollin L, Marx D, et al. Roflumilast inhibition of pulmonary leukotriene production and bronchoconstriction in ovalbumin-sensitized and -challenged Guinea pigs. J Asthma. 2005 Dec;42(10):873-8.

[4]Martorana PA, Beume R, et al. Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke. Am J Respir Crit Care Med. 2005 Oct 1;172(7):848-53. Epub 2005 Jun 16.

[5]Kasetty G, Papareddy P, et al. Roflumilast Increases Bacterial Load and Dissemination in a Model of Pseudomononas Aeruginosa Airway Infection. J Pharmacol Exp Ther. 2016 Apr;357(1):66-72.

[6]Roflumilast

[7]Card GL, England BP, Suzuki Y, Fong D, Powell B, Lee B, Luu C, Tabrizizad M, Gillette S, Ibrahim PN, Artis DR, Bollag G, Milburn MV, Kim SH, Schlessinger J, Zhang KY. Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure. 2004 Dec;12(12):2233-47.

[8]Mata M, Sarriá B, Buenestado A, Cortijo J, Cerdá M, Morcillo EJ. Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells. Thorax. 2005 Feb;60(2):144-52.

[9]Raju SV, Rasmussen L, Sloane PA, Tang LP, Libby EF, Rowe SM. Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice. Respir Res. 2017 Sep 18;18(1):173.

 

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