RKI1447
|
- $55 - $2691.1
- Product name: RKI1447
- CAS: 1342278-01-6
- MF: C16H14N4O2S
- MW: 326.37
- EINECS:200-256-5
- MDL Number:MFCD26142658
- Synonyms:RKI1447;1-(3-HYDROXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA;Urea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-;1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea RKI 1447;RKI 1447 1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea;RKI-1447, >=98%;CS-855;RKI 1447; RKI1447
31 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1000mg
- 1g
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberY1875
- Product descriptionRKI-1447
- Packaging50mg
- Price$522
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging10mM(in 1mL DMSO)
- Price$99
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging10mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging25mg
- Price$240
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging50mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2229
- Product descriptionRKI1447 99%
- Packaging10mg
- Price$115.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181117
- Product descriptionRKI-1447 >98%
- Packaging100mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181117
- Product descriptionRKI-1447 >98%
- Packaging250mg
- Price$1356.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181117
- Product descriptionRKI-1447 >98%
- Packaging1000mg
- Price$2691.1
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBR172011
- Product descriptionRKI-1447 NEW
- Packaging100mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBR172011
- Product descriptionRKI-1447 NEW
- Packaging50mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBR172011
- Product descriptionRKI-1447 NEW
- Packaging25mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBR172011
- Product descriptionRKI-1447 NEW
- Packaging10mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBR172011
- Product descriptionRKI-1447 NEW
- Packaging5mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16278
- Product descriptionRKI-1447 ≥98%
- Packaging50mg
- Price$422
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | Y1875 | RKI-1447 | 50mg | $522 | 2021-12-16 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 5mg | $60 | 2021-12-16 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 10mM(in 1mL DMSO) | $99 | 2021-12-16 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 10mg | $110 | 2021-12-16 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 25mg | $240 | 2021-12-16 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 50mg | $400 | 2021-12-16 | Buy |
| Axon Medchem | Axon2229 | RKI1447 99% | 10mg | $115.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181117 | RKI-1447 >98% | 100mg | $690.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181117 | RKI-1447 >98% | 250mg | $1356.6 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181117 | RKI-1447 >98% | 1000mg | $2691.1 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BR172011 | RKI-1447 NEW | 100mg | $600 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BR172011 | RKI-1447 NEW | 50mg | $350 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BR172011 | RKI-1447 NEW | 25mg | $200 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BR172011 | RKI-1447 NEW | 10mg | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BR172011 | RKI-1447 NEW | 5mg | $55 | 2021-12-16 | Buy |
| Cayman Chemical | 16278 | RKI-1447 ≥98% | 50mg | $422 | 2024-03-01 | Buy |
Properties
Melting point :>205oC (dec.)
Density :1.408±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :6.36±0.70(Predicted)
form :Solid
color :Pale Yellow to Pale Beige
Density :1.408±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :6.36±0.70(Predicted)
form :Solid
color :Pale Yellow to Pale Beige
Safety Information
| Symbol(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
RKI-1447 is an inhibitor of the Rho-associated kinases ROCK-I and II (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 without effect on the phosphorylation of Akt, MEK, or S6 kinase. Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC50 = 709 nM).More related product prices
AZD-9291 864082-47-3 Fasudil hydrochloride 1,9-Pyrazoloanthrone Y27632 (hydrochloride) Thiazovivin RN486 946387-07-1 RN-1 (hydrochloride)Related product price
- AZD-9291
$32-988 - 864082-47-3
$34-5935 - Fasudil hydrochloride
$14-2245.7
