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ChemicalBook >> CAS DataBase List >> Mubritinib

Mubritinib

Mubritinib price.
  • $28 - $2023
  • Product name: Mubritinib
  • CAS: 366017-09-6
  • MF: C25H23F3N4O2
  • MW: 468.47
  • EINECS:
  • MDL Number:MFCD09954135
  • Synonyms:MUBRITINIB;1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole;TAK 165;Mubritinib(TAK 165);(E)-1-(4-(4-((2-(4-(trifluoromethyl)styryl)oxazol-4-yl)methoxy)phenyl)butyl)-1H-1,2,3-triazole;1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole Mubritinib (TAK 165);Mubritinib 1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole;(E)-4-((4-(4-(1H-1,2,3-Triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole
37 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
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  • 20mg
  • 25mg
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  • 100mg
  • 50
  • 200mg
  • 250mg
  • 1000mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3755-M025
  • Product descriptionMubritinib ≥95%
  • Packaging25mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1112
  • Product descriptionMubritinib
  • Packaging5mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1112
  • Product descriptionMubritinib
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000892
  • Product descriptionMUBRITINIB 95.00%
  • Packaging1MG
  • Price$166.95
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000892
  • Product descriptionMUBRITINIB 95.00%
  • Packaging10MG
  • Price$726.44
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000892
  • Product descriptionMUBRITINIB 95.00%
  • Packaging50MG
  • Price$1352.22
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1543
  • Product descriptionMubritinib(TAK165)
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1543
  • Product descriptionMubritinib(TAK165)
  • Packaging10mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1543
  • Product descriptionMubritinib(TAK165)
  • Packaging25mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1543
  • Product descriptionMubritinib(TAK165)
  • Packaging200mg
  • Price$610
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60330
  • Product descriptionMubritinib(TAK165)
  • Packaging20mg
  • Price$238
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180989
  • Product descriptionMubritinib (TAK 165) >98%
  • Packaging100mg
  • Price$606.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180989
  • Product descriptionMubritinib (TAK 165) >98%
  • Packaging250mg
  • Price$912.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180989
  • Product descriptionMubritinib (TAK 165) >98%
  • Packaging1000mg
  • Price$2023
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFM32802
  • Product descriptionMubritinib
  • Packaging10mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFM32802
  • Product descriptionMubritinib
  • Packaging50mg
  • Price$262.5
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3755-M025 Mubritinib ≥95% 25mg $120 2021-12-16 Buy
AK Scientific SYN1112 Mubritinib 5mg $85 2021-12-16 Buy
AK Scientific SYN1112 Mubritinib 10mg $90 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000892 MUBRITINIB 95.00% 1MG $166.95 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000892 MUBRITINIB 95.00% 10MG $726.44 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000892 MUBRITINIB 95.00% 50MG $1352.22 2021-12-16 Buy
ApexBio Technology B1543 Mubritinib(TAK165) 1unit $28 2021-12-16 Buy
ApexBio Technology B1543 Mubritinib(TAK165) 10mg $50 2021-12-16 Buy
ApexBio Technology B1543 Mubritinib(TAK165) 25mg $105 2021-12-16 Buy
ApexBio Technology B1543 Mubritinib(TAK165) 200mg $610 2021-12-16 Buy
Arctom CFN60330 Mubritinib(TAK165) 20mg $238 2021-12-16 Buy
Biorbyt Ltd orb180989 Mubritinib (TAK 165) >98% 100mg $606.9 2021-12-16 Buy
Biorbyt Ltd orb180989 Mubritinib (TAK 165) >98% 250mg $912.9 2021-12-16 Buy
Biorbyt Ltd orb180989 Mubritinib (TAK 165) >98% 1000mg $2023 2021-12-16 Buy
Biosynth Carbosynth FM32802 Mubritinib 10mg $75 2021-12-16 Buy
Biosynth Carbosynth FM32802 Mubritinib 50mg $262.5 2021-12-16 Buy

Properties

Melting point :158.0 to 162.0 °C
Boiling point :620.9±65.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :DMSO : 50 mg/mL (106.73 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
pka :1.45±0.10(Predicted)
form :powder to crystal
color :White to Gray to Brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Mubritinib is a selective inhibitor of the human epidermal growth factor receptor 2 (HER2), inhibiting HER2 phosphorylation with an IC50 value of 6 nM. It is without effect on EGFR, FGFR, PDGFR, JAK1, Src, and Blk (IC50 > 25 μM). Mubritinib inhibits the proliferation of breast, bladder, kidney, and prostate cancer cells in vitro and in vivo.

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