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ChemicalBook >> CAS DataBase List >> Lapatinib

Lapatinib

Lapatinib price.
  • $20 - $1500
  • Product name: Lapatinib
  • CAS: 231277-92-2
  • MF: C29H26ClFN4O4S
  • MW: 581.06
  • EINECS:1806241-263-5
  • MDL Number:MFCD09264194
  • Synonyms:lapatinib;n-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine;4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-;Lapatinib(TINIBS);Lapatinib Base N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-Quinazolinamine;GW2016 LAPATINIB;N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine;N-{3-chloro-4-[(3-fluorobenzyl)oxyl]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine
50 prices
Selected condition：
Brand
  • AccelPharmtech
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Tocris
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10MG
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 10
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • 2g
  • 5G
  • 10G
  • 25g
  • 10mM(in 1mL DMSO)
  • ManufacturerAccelPharmtech
  • Product numberAT7855
  • Product descriptionLapatinib 99.00%
  • Packaging5G
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberAT7855
  • Product descriptionLapatinib 99.00%
  • Packaging10G
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1052-M050
  • Product descriptionLapatinib ≥95%
  • Packaging50mg
  • Price$205
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberQ570
  • Product descriptionLapatinib
  • Packaging5mg
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ90020
  • Product descriptionLapatinib
  • Packaging25mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ90020
  • Product descriptionLapatinib
  • Packaging1g
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA254504
  • Product descriptionN-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine 98%
  • Packaging50mg
  • Price$20
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA254504
  • Product descriptionN-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine 98%
  • Packaging100mg
  • Price$27
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA254504
  • Product descriptionN-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine 98%
  • Packaging250mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA254504
  • Product descriptionN-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine 98%
  • Packaging1g
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA254504
  • Product descriptionN-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine 98%
  • Packaging5g
  • Price$206
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA254504
  • Product descriptionN-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine 98%
  • Packaging25g
  • Price$623
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003126
  • Product descriptionLAPATINIB 95.00%
  • Packaging10MG
  • Price$755.48
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8218
  • Product descriptionLapatinib
  • Packaging50mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8218
  • Product descriptionLapatinib
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8218
  • Product descriptionLapatinib
  • Packaging100mg
  • Price$70
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AccelPharmtech AT7855 Lapatinib 99.00% 5G $170 2021-12-16 Buy
AccelPharmtech AT7855 Lapatinib 99.00% 10G $240 2021-12-16 Buy
Adipogen Life Sciences SYN-1052-M050 Lapatinib ≥95% 50mg $205 2021-12-16 Buy
AK Scientific Q570 Lapatinib 5mg $28 2021-12-16 Buy
AK Scientific J90020 Lapatinib 25mg $49 2021-12-16 Buy
AK Scientific J90020 Lapatinib 1g $160 2021-12-16 Buy
Ambeed A254504 N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine 98% 50mg $20 2021-12-16 Buy
Ambeed A254504 N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine 98% 100mg $27 2021-12-16 Buy
Ambeed A254504 N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine 98% 250mg $40 2021-12-16 Buy
Ambeed A254504 N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine 98% 1g $55 2021-12-16 Buy
Ambeed A254504 N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine 98% 5g $206 2021-12-16 Buy
Ambeed A254504 N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine 98% 25g $623 2021-12-16 Buy
American Custom Chemicals Corporation API0003126 LAPATINIB 95.00% 10MG $755.48 2021-12-16 Buy
ApexBio Technology A8218 Lapatinib 50mg $50 2021-12-16 Buy
ApexBio Technology A8218 Lapatinib 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology A8218 Lapatinib 100mg $70 2021-12-16 Buy

Properties

Melting point :144-146oC
Boiling point :750.7±60.0 °C(Predicted)
Density :1.381±0.06 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :Soluble in DMSO (up to 200 mg/ml)
form :solid
pka :6.34±0.19(Predicted)
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :BCFGMOOMADDAQU-UHFFFAOYSA-N
SMILES :N1=C2C(C=C(C3=CC=C(CNCCS(C)(=O)=O)O3)C=C2)=C(NC2=CC=C(OCC3=CC=CC(F)=C3)C(Cl)=C2)N=C1
CAS DataBase Reference :231277-92-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H362 May cause harm to breast-fed children Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P201 Obtain special instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy/while nursing.
P273 Avoid release to the environment.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

The epidermal growth factor (EGF) receptors EGFR (ErbB1) and human EGFR2 (HER2, ErbB2) are receptor tyrosine kinases that are often over-expressed in cancer. Lapatinib is a potent and selective dual inhibitor of EGFR and HER2 (IC50s = 19 and 3 nM, respectively). It is effective in vivo and is used in combination therapy to prevent or suppress cancers where these kinases are over-expressed, including breast cancer.

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