LDE-225 Diphosphate
|
- $32 - $1802
- Product name: LDE-225 Diphosphate
- CAS: 1218778-77-8
- MF: C26H32F3N3O11P2
- MW: 681.4885116
- EINECS:
- MDL Number:MFCD16627994
- Synonyms:LDE225 Diphosphate, >=98%;Erismodegib Diphosphate, NVP-LDE225 (diphosphate salt);ErisModegib Diphosphate;LDE 225 Diphosphate;LDE225 (Diphosphate);LDE-225 Diphosphate;NVP-LDE 225 Diphosphate;LDE 225 phosphate
23 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1MG
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1000mg
- ManufacturerAK Scientific
- Product numberSYN5720
- Product descriptionNVP-LDE225Diphosphatesalt
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001229
- Product descriptionNVP-LDE225 DIPHOSPHATE 95.00%
- Packaging1MG
- Price$699.76
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001229
- Product descriptionNVP-LDE225 DIPHOSPHATE 95.00%
- Packaging5MG
- Price$903.33
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001229
- Product descriptionNVP-LDE225 DIPHOSPHATE 95.00%
- Packaging10MG
- Price$1027.2
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3543
- Product descriptionLDE225Diphosphate
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181047
- Product descriptionLDE225 Diphosphate >98%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181047
- Product descriptionLDE225 Diphosphate >98%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181047
- Product descriptionLDE225 Diphosphate >98%
- Packaging1000mg
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16263
- Product descriptionLDE225 (phosphate) ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16263
- Product descriptionLDE225 (phosphate) ≥98%
- Packaging5mg
- Price$116
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16263
- Product descriptionLDE225 (phosphate) ≥98%
- Packaging10mg
- Price$199
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16263
- Product descriptionLDE225 (phosphate) ≥98%
- Packaging25mg
- Price$456
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-1175
- Product descriptionSonidegibdiphosphate 99.80%
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1175
- Product descriptionSonidegibdiphosphate 99.80%
- Packaging10mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1175
- Product descriptionSonidegibdiphosphate 99.80%
- Packaging50mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1175
- Product descriptionSonidegibdiphosphate 99.80%
- Packaging100mg
- Price$220
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5720 | NVP-LDE225Diphosphatesalt | 10mg | $160 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001229 | NVP-LDE225 DIPHOSPHATE 95.00% | 1MG | $699.76 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001229 | NVP-LDE225 DIPHOSPHATE 95.00% | 5MG | $903.33 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001229 | NVP-LDE225 DIPHOSPHATE 95.00% | 10MG | $1027.2 | 2021-12-16 | Buy |
| ApexBio Technology | A3543 | LDE225Diphosphate | 5mg | $50 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181047 | LDE225 Diphosphate >98% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181047 | LDE225 Diphosphate >98% | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181047 | LDE225 Diphosphate >98% | 1000mg | $1802 | 2021-12-16 | Buy |
| Cayman Chemical | 16263 | LDE225 (phosphate) ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16263 | LDE225 (phosphate) ≥98% | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 16263 | LDE225 (phosphate) ≥98% | 10mg | $199 | 2024-03-01 | Buy |
| Cayman Chemical | 16263 | LDE225 (phosphate) ≥98% | 25mg | $456 | 2024-03-01 | Buy |
| ChemScene | CS-1175 | Sonidegibdiphosphate 99.80% | 5mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-1175 | Sonidegibdiphosphate 99.80% | 10mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-1175 | Sonidegibdiphosphate 99.80% | 50mg | $130 | 2021-12-16 | Buy |
| ChemScene | CS-1175 | Sonidegibdiphosphate 99.80% | 100mg | $220 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :≥27.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :White solid.
color :White to off-white
solubility :≥27.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :White solid.
color :White to off-white
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of the GPCR-like receptor, Smoothened (SMO). In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers. LDE225 is an Hh signaling pathway inhibitor that acts by antagonizing SMO (IC50s = 1.3 and 2.5 nM for mouse and human, respectively). A dose of 20 mg/kg/day LDE225 has been shown to penetrate the blood brain barrier, inhibit Gli1 mRNA expression, and prevent tumor growth in a medulloblastoma allograft mouse model. This compound has been investigated in phase II clinical trials for potential treatment of several Hh pathway activated cancers.Related product price
- Purmorphamine
$28-2691.1 - 329196-48-7
$35-1253 - Smoothened Agonist, HCl
$117-1030
