Encorafenib (LGX818)
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- $37 - $5210.5
- Product name: Encorafenib (LGX818)
- CAS: 1269440-17-6
- MF: C22H27ClFN7O4S
- MW: 540.01
- EINECS:
- MDL Number:MFCD25976758
- Synonyms:LGX 818;LGX-818;(S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate;Encorafenib (LGX818);Carbamic acid, N-[(1S)-2-[[4-[3-[5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-methylethyl]-, methyl ester;LGX 818 (S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate;LGX818, >=98%;LGX818, Encorafenib
27 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 500μg
- 0.5mg
- 500ug
- 1MG
- 2mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberY1910
- Product descriptionLGX-818
- Packaging2mg
- Price$225
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0018401
- Product descriptionLGX-818 95.00%
- Packaging5MG
- Price$495.87
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0018401
- Product descriptionLGX-818 95.00%
- Packaging1MG
- Price$305.55
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1174
- Product descriptionLGX818
- Packaging1mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1174
- Product descriptionLGX818
- Packaging5mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180851
- Product descriptionLGX-818(Encorafenib) >98%
- Packaging100mg
- Price$1431.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180851
- Product descriptionLGX-818(Encorafenib) >98%
- Packaging250mg
- Price$2618
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180851
- Product descriptionLGX-818(Encorafenib) >98%
- Packaging1g
- Price$5210.5
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC65061
- Product descriptionLGX 818
- Packaging1mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC65061
- Product descriptionLGX 818
- Packaging2mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC65061
- Product descriptionLGX 818
- Packaging5mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC65061
- Product descriptionLGX 818
- Packaging10mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC65061
- Product descriptionLGX 818
- Packaging25mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16994
- Product descriptionEncorafenib ≥98%
- Packaging500μg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16994
- Product descriptionEncorafenib ≥98%
- Packaging1mg
- Price$70
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16994
- Product descriptionEncorafenib ≥98%
- Packaging5mg
- Price$163
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | Y1910 | LGX-818 | 2mg | $225 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0018401 | LGX-818 95.00% | 5MG | $495.87 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0018401 | LGX-818 95.00% | 1MG | $305.55 | 2021-12-16 | Buy |
| ApexBio Technology | B1174 | LGX818 | 1mg | $90 | 2021-12-16 | Buy |
| ApexBio Technology | B1174 | LGX818 | 5mg | $185 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180851 | LGX-818(Encorafenib) >98% | 100mg | $1431.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180851 | LGX-818(Encorafenib) >98% | 250mg | $2618 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180851 | LGX-818(Encorafenib) >98% | 1g | $5210.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC65061 | LGX 818 | 1mg | $90 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC65061 | LGX 818 | 2mg | $130 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC65061 | LGX 818 | 5mg | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC65061 | LGX 818 | 10mg | $400 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC65061 | LGX 818 | 25mg | $650 | 2021-12-16 | Buy |
| Cayman Chemical | 16994 | Encorafenib ≥98% | 500μg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 16994 | Encorafenib ≥98% | 1mg | $70 | 2024-03-01 | Buy |
| Cayman Chemical | 16994 | Encorafenib ≥98% | 5mg | $163 | 2024-03-01 | Buy |
Properties
Melting point :184-185°C
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :5.94±0.10(Predicted)
form :Solid
color :White to Off-White
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :5.94±0.10(Predicted)
form :Solid
color :White to Off-White
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. A mutation of B-Raf in exon 15 at codon 600 where a valine is substituted by glutamic acid (V600E) has been linked to melanoma. Encorafenib is a selective inhibitor of B-RafV600E mutant melanoma cell proliferation (EC50 = 4 nM) with little activity against wild-type B-Raf or a panel of 100 other kinases (IC50s = 900 nM). At oral doses of 6 mg/kg in human melanoma xenograft models, encorafenib was shown to decrease phosphorylation of the B-Raf substrate MEK.Related product price
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