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      ChemicalBook >> CAS DataBase List >> Disulfiram

      Disulfiram

      Disulfiram price.
      • $13.44 - $1504.5
      • Product name: Disulfiram
      • CAS: 97-77-8
      • MF: C10H20N2S4
      • MW: 296.54
      • EINECS:202-607-8
      • MDL Number:MFCD00009048
      • Synonyms:Tillram;TTS x;Tuads, ethyl;1,1’-dithiobis(n,n-diethylthio-formamid ;1,1’-dithiobis(n,n-diethylthioformamide) ;1,1'-Dithiobis(N,N-diethylthioformamide);Abstenisil ;Abstensil
      42 prices
      Selected condition:
      Brand
      • AK Scientific
      • Alfa Aesar
      • American Custom Chemicals Corporation
      • Aronis compounds
      • Biorbyt Ltd
      • Biosynth Carbosynth
      • Cayman Chemical
      • Chem-Impex
      • ChemScene
      • CSNpharm
      • DC Chemicals
      • Frontier Specialty Chemicals
      • Matrix Scientific
      • Medical Isotopes, Inc.
      • Sigma-Aldrich
      • TCI Chemical
      • Tocris
      • TRC
      • Usbiological
      Package
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      • d2950000
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      • 1GT
      • ManufacturerAK Scientific
      • Product numberJ53113
      • Product descriptionDisulfiram
      • Packaging25g
      • Price$20
      • Updated2021-12-16
      • Buy
      • ManufacturerAlfa Aesar
      • Product numberB20721
      • Product descriptionTetraethylthiuram disulfide, 97%
      • Packaging250g
      • Price$40.65
      • Updated2024-03-01
      • Buy
      • ManufacturerAlfa Aesar
      • Product numberB20721
      • Product descriptionTetraethylthiuram disulfide, 97%
      • Packaging1000g
      • Price$109.65
      • Updated2024-03-01
      • Buy
      • ManufacturerAlfa Aesar
      • Product numberB20721
      • Product descriptionTetraethylthiuram disulfide, 97%
      • Packaging5000g
      • Price$406.65
      • Updated2024-03-01
      • Buy
      • ManufacturerAmerican Custom Chemicals Corporation
      • Product numberAPI0002428
      • Product descriptionTETRAETHYLTHIURAM DISULFIDE 95.00%
      • Packaging5MG
      • Price$521
      • Updated2021-12-16
      • Buy
      • ManufacturerAmerican Custom Chemicals Corporation
      • Product numberAPI0002428
      • Product descriptionTETRAETHYLTHIURAM DISULFIDE 95.00%
      • Packaging1GT
      • Price$1290.15
      • Updated2021-12-16
      • Buy
      • ManufacturerAronis compounds
      • Product numberBBC/257
      • Product description1,1',1'',1'''-{disulfanediylbis[(thioxomethylene)nitrilo]}tetraethane
      • Packaging1g
      • Price$133
      • Updated2021-12-16
      • Buy
      • ManufacturerBiorbyt Ltd
      • Product numberorb134703
      • Product descriptionDisulfiram (Antabuse) >99%
      • Packaging100mg
      • Price$510
      • Updated2021-12-16
      • Buy
      • ManufacturerBiorbyt Ltd
      • Product numberorb134703
      • Product descriptionDisulfiram (Antabuse) >99%
      • Packaging250mg
      • Price$765
      • Updated2021-12-16
      • Buy
      • ManufacturerBiorbyt Ltd
      • Product numberorb134703
      • Product descriptionDisulfiram (Antabuse) >99%
      • Packaging1g
      • Price$1504.5
      • Updated2021-12-16
      • Buy
      • ManufacturerBiosynth Carbosynth
      • Product numberFD22545
      • Product descriptionDisulfiram
      • Packaging100g
      • Price$75
      • Updated2021-12-16
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      • ManufacturerBiosynth Carbosynth
      • Product numberFD22545
      • Product descriptionDisulfiram
      • Packaging250g
      • Price$125
      • Updated2021-12-16
      • Buy
      • ManufacturerBiosynth Carbosynth
      • Product numberFD22545
      • Product descriptionDisulfiram
      • Packaging500g
      • Price$160
      • Updated2021-12-16
      • Buy
      • ManufacturerBiosynth Carbosynth
      • Product numberFD22545
      • Product descriptionDisulfiram
      • Packaging1kg
      • Price$200
      • Updated2021-12-16
      • Buy
      • ManufacturerCayman Chemical
      • Product number15303
      • Product descriptionDisulfiram ≥95%
      • Packaging50g
      • Price$30
      • Updated2024-03-01
      • Buy
      • ManufacturerCayman Chemical
      • Product number15303
      • Product descriptionDisulfiram ≥95%
      • Packaging100g
      • Price$44
      • Updated2024-03-01
      • Buy
      Manufacturer Product number Product description Packaging Price Updated Buy
      AK Scientific J53113 Disulfiram 25g $20 2021-12-16 Buy
      Alfa Aesar B20721 Tetraethylthiuram disulfide, 97% 250g $40.65 2024-03-01 Buy
      Alfa Aesar B20721 Tetraethylthiuram disulfide, 97% 1000g $109.65 2024-03-01 Buy
      Alfa Aesar B20721 Tetraethylthiuram disulfide, 97% 5000g $406.65 2024-03-01 Buy
      American Custom Chemicals Corporation API0002428 TETRAETHYLTHIURAM DISULFIDE 95.00% 5MG $521 2021-12-16 Buy
      American Custom Chemicals Corporation API0002428 TETRAETHYLTHIURAM DISULFIDE 95.00% 1GT $1290.15 2021-12-16 Buy
      Aronis compounds BBC/257 1,1',1'',1'''-{disulfanediylbis[(thioxomethylene)nitrilo]}tetraethane 1g $133 2021-12-16 Buy
      Biorbyt Ltd orb134703 Disulfiram (Antabuse) >99% 100mg $510 2021-12-16 Buy
      Biorbyt Ltd orb134703 Disulfiram (Antabuse) >99% 250mg $765 2021-12-16 Buy
      Biorbyt Ltd orb134703 Disulfiram (Antabuse) >99% 1g $1504.5 2021-12-16 Buy
      Biosynth Carbosynth FD22545 Disulfiram 100g $75 2021-12-16 Buy
      Biosynth Carbosynth FD22545 Disulfiram 250g $125 2021-12-16 Buy
      Biosynth Carbosynth FD22545 Disulfiram 500g $160 2021-12-16 Buy
      Biosynth Carbosynth FD22545 Disulfiram 1kg $200 2021-12-16 Buy
      Cayman Chemical 15303 Disulfiram ≥95% 50g $30 2024-03-01 Buy
      Cayman Chemical 15303 Disulfiram ≥95% 100g $44 2024-03-01 Buy

      Properties

      Melting point :69-71 °C (lit.)
      Boiling point :117°C
      Density :1.27
      vapor pressure :0Pa at 25℃
      refractive index :1.5500 (estimate)
      Flash point :117°C/17mm
      storage temp. :2-8°C
      solubility :0.004g/l
      pka :0.86±0.50(Predicted)
      form :Crystals, Crystalline Powder or Granules
      color :Light yellow
      Odor :lt. gray powd., sl. odor
      Water Solubility :0.02 g/100 mL
      Merck :14,3364
      BRN :1712560
      Exposure limits :ACGIH: TWA 2 mg/m3
      NIOSH: TWA 2 mg/m3 Stability :Stable. Incompatible with strong oxidants.
      InChIKey :AUZONCFQVSMFAP-UHFFFAOYSA-N
      LogP :3.6 at 21℃
      CAS DataBase Reference :97-77-8(CAS DataBase Reference)
      NIST Chemistry Reference :Disulfiram(97-77-8)
      IARC :3 (Vol. 12, Sup 7) 1987
      EPA Substance Registry System :Disulfiram (97-77-8)

      Safety Information

      Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
      Signal word: Warning
      Hazard statements:
      Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
      H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
      H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
      H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
      H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
      Precautionary statements:
      P273 Avoid release to the environment.
      P280 Wear protective gloves/protective clothing/eye protection/face protection.
      P302+P352 IF ON SKIN: wash with plenty of soap and water.
      P314 Get medical advice/attention if you feel unwell.

      Description

      Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM) that has been indicated for the treatment of alcohol dependence. It also inhibits the copper-dependent enzyme dopamine β-hydroxylase, which prevents the breakdown of dopamine and has been considered as a treatment for cocaine dependence. When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 μM) and 26S proteasome (IC50 = 20 μM) from MDA-MB-0231 breast cancer cells. Because disulfiram targets the ubiquitin-proteasome pathway, it has been investigated as an anti-cancer agent. Furthermore, at 250 nM it has been shown to induce reactive oxygen species, to activate JNK and p38 pathways, and to inhibit NF-κB activity, which suppresses self-renewal in cancer stem cells.

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