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ChemicalBook >> CAS DataBase List >> Cyclosporin A

Cyclosporin A

Cyclosporin A price.
  • $10 - $2269.5
  • Product name: Cyclosporin A
  • CAS: 59865-13-3
  • MF: C62H111N11O12
  • MW: 1202.61
  • EINECS:611-907-1
  • MDL Number:MFCD00274558
  • Synonyms:ol27-400 ;s7481f1 ;sandimmun ;Cyclospori;1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane, cyclic peptide deriv.;30-Ethyl-33-(1-hydroxy-2-methyl-hex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone;Cipol N;Neoplanta
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  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0079-M100
  • Product descriptionCyclosporin A ≥98%
  • Packaging100mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0079-5100
  • Product descriptionCyclosporin A ≥98%
  • Packaging5x100mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH890
  • Product descriptionCyclosporin A
  • Packaging5g
  • Price$417
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ63191
  • Product descriptionCyclosporin A, 99+%
  • Packaging1g
  • Price$227
  • Updated2024-03-01
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  • ManufacturerAlfa Aesar
  • Product numberJ63191
  • Product descriptionCyclosporin A, 99+%
  • Packaging5g
  • Price$487
  • Updated2024-03-01
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  • ManufacturerApolloscientific
  • Product numberBITP1533
  • Product descriptionCyclosporineAfromBeauverianlyea
  • Packaging1g
  • Price$85
  • Updated2021-12-16
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  • ManufacturerApolloscientific
  • Product numberBITP1533
  • Product descriptionCyclosporineAfromBeauverianlyea
  • Packaging4g
  • Price$203
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS569732
  • Product description(3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29, 97%
  • Packaging25mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS569732
  • Product description(3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29, 97%
  • Packaging100mg
  • Price$13
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS569732
  • Product description(3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29, 97%
  • Packaging250mg
  • Price$18
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberCFN60180
  • Product descriptionCyclosporin A ≥98%
  • Packaging20mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS569732
  • Product description(3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29, 97%
  • Packaging1g
  • Price$36
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberSY012000
  • Product descriptionCyclosporin A ≥98%
  • Packaging5g
  • Price$115
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS569732
  • Product description(3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29, 97%
  • Packaging5g
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS569732
  • Product description(3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29, 97%
  • Packaging25g
  • Price$346
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545830
  • Product descriptionCyclosporine >98%
  • Packaging100mg
  • Price$154.7
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CN2-0079-M100 Cyclosporin A ≥98% 100mg $45 2021-12-16 Buy
Adipogen Life Sciences AG-CN2-0079-5100 Cyclosporin A ≥98% 5x100mg $135 2021-12-16 Buy
AK Scientific H890 Cyclosporin A 5g $417 2021-12-16 Buy
Alfa Aesar J63191 Cyclosporin A, 99+% 1g $227 2024-03-01 Buy
Alfa Aesar J63191 Cyclosporin A, 99+% 5g $487 2024-03-01 Buy
Apolloscientific BITP1533 CyclosporineAfromBeauverianlyea 1g $85 2021-12-16 Buy
Apolloscientific BITP1533 CyclosporineAfromBeauverianlyea 4g $203 2021-12-16 Buy
Arctom AS569732 (3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29, 97% 25mg $10 2021-12-16 Buy
Arctom AS569732 (3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29, 97% 100mg $13 2021-12-16 Buy
Arctom AS569732 (3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29, 97% 250mg $18 2021-12-16 Buy
Arctom CFN60180 Cyclosporin A ≥98% 20mg $30 2021-12-16 Buy
Arctom AS569732 (3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29, 97% 1g $36 2021-12-16 Buy
Arctom SY012000 Cyclosporin A ≥98% 5g $115 2021-12-16 Buy
Arctom AS569732 (3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29, 97% 5g $140 2021-12-16 Buy
Arctom AS569732 (3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29, 97% 25g $346 2021-12-16 Buy
Biorbyt Ltd orb545830 Cyclosporine >98% 100mg $154.7 2021-12-16 Buy

Properties

Melting point :148-151°C
Boiling point :838.63°C (rough estimate)
alpha :D20 -244° (c = 0.6 in chloroform); D20 -189° (c = 0.5 in methanol)
Density :0.9913 (rough estimate)
refractive index :1.6500 (estimate)
Flash point :87℃
storage temp. :-20°C
solubility :ethanol: 30 mg/mL
form :solid
pka :13.32±0.70(Predicted)
color :white
optical activity :-18922 (methanol)
Water Solubility :Soluble in dimethyl sulfoxide and ethanol. Insoluble in water.
Merck :14,2752
BRN :3647785
Stability :Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :PMATZTZNYRCHOR-CGLBZJNRSA-N
CAS DataBase Reference :59865-13-3(CAS DataBase Reference)
IARC :1 (Vol. 50, 100A) 2012
EPA Substance Registry System :Cyclosporin A (59865-13-3)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Cyclosporin A is an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC50 = 5 nM). It blocks the transcription of genes involved in T cell activation by interfering with the calcineurin-driven nuclear import of the transcription factor NFAT. Because of its powerful immunosuppressant activity, cyclosporin A has long been used for the prevention of transplant rejection.

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