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ChemicalBook >> CAS DataBase List >> Clotrimazole

Clotrimazole

Clotrimazole price.
  • $10 - $927
  • Product name: Clotrimazole
  • CAS: 23593-75-1
  • MF: C22H17ClN2
  • MW: 344.84
  • EINECS:245-764-8
  • MDL Number:MFCD00057220
  • Synonyms:component of Otomax;Empecid;FB 5097;fb5097 ;Gyne lotrimin;Imidazole, 1-(o-chloro-alpha,alpha-diphenylbenzyl)-;Methane, bis-phenyl-(2-chlorophenyl)-1-imidazolyl-;Mono-baycuten
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  • c2430000
  • ManufacturerAHH
  • Product numberMT-49455
  • Product descriptionClotrimazole 98%
  • Packaging250g
  • Price$440
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product numberN713
  • Product descriptionClotrimazole
  • Packaging5g
  • Price$34
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product numberJ99593
  • Product descriptionClotrimazole
  • Packaging1g
  • Price$10
  • Updated2021-12-16
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  • ManufacturerAlfa Aesar
  • Product numberJ63895
  • Product descriptionClotrimazole
  • Packaging5g
  • Price$66.65
  • Updated2024-03-01
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  • ManufacturerAlfa Aesar
  • Product numberJ63895
  • Product descriptionClotrimazole
  • Packaging25g
  • Price$232.65
  • Updated2024-03-01
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002086
  • Product descriptionCLOTRIMAZOLE 95.00%
  • Packaging1G
  • Price$123.9
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA8401
  • Product descriptionClotrimazole
  • Packaging1g
  • Price$70
  • Updated2021-12-16
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  • ManufacturerAxon Medchem
  • Product numberAxon3163
  • Product descriptionClotrimazole-BAYb5097 98%
  • Packaging50mg
  • Price$55
  • Updated2021-12-16
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  • ManufacturerCayman Chemical
  • Product number15278
  • Product descriptionClotrimazole ≥98%
  • Packaging50mg
  • Price$32
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number15278
  • Product descriptionClotrimazole ≥98%
  • Packaging100mg
  • Price$41
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number15278
  • Product descriptionClotrimazole ≥98%
  • Packaging1g
  • Price$57
  • Updated2024-03-01
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  • ManufacturerChem-Impex
  • Product number01311
  • Product descriptionClotrimazole,99%(Assay) 99%(Assay)
  • Packaging250G
  • Price$666.4
  • Updated2021-12-16
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  • ManufacturerChem-Impex
  • Product number01311
  • Product descriptionClotrimazole,≥99%(Assay)Antibiotic ≥99%(Assay)
  • Packaging100G
  • Price$343.62
  • Updated2021-12-16
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  • ManufacturerChem-Impex
  • Product number01311
  • Product descriptionClotrimazole,≥99%(Assay)Antibiotic ≥99%(Assay)
  • Packaging25G
  • Price$93.18
  • Updated2021-12-16
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  • ManufacturerChem-Impex
  • Product number01311
  • Product descriptionClotrimazole,≥99%(Assay)Antibiotic ≥99%(Assay)
  • Packaging5G
  • Price$29.12
  • Updated2021-12-16
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  • ManufacturerChem-Impex
  • Product number01311
  • Product descriptionClotrimazole,≥99%(Assay)Antibiotic ≥99%(Assay)
  • Packaging1G
  • Price$17.47
  • Updated2021-12-16
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Manufacturer Product number Product description Packaging Price Updated Buy
AHH MT-49455 Clotrimazole 98% 250g $440 2021-12-16 Buy
AK Scientific N713 Clotrimazole 5g $34 2021-12-16 Buy
AK Scientific J99593 Clotrimazole 1g $10 2021-12-16 Buy
Alfa Aesar J63895 Clotrimazole 5g $66.65 2024-03-01 Buy
Alfa Aesar J63895 Clotrimazole 25g $232.65 2024-03-01 Buy
American Custom Chemicals Corporation API0002086 CLOTRIMAZOLE 95.00% 1G $123.9 2021-12-16 Buy
ApexBio Technology A8401 Clotrimazole 1g $70 2021-12-16 Buy
Axon Medchem Axon3163 Clotrimazole-BAYb5097 98% 50mg $55 2021-12-16 Buy
Cayman Chemical 15278 Clotrimazole ≥98% 50mg $32 2024-03-01 Buy
Cayman Chemical 15278 Clotrimazole ≥98% 100mg $41 2024-03-01 Buy
Cayman Chemical 15278 Clotrimazole ≥98% 1g $57 2024-03-01 Buy
Chem-Impex 01311 Clotrimazole,99%(Assay) 99%(Assay) 250G $666.4 2021-12-16 Buy
Chem-Impex 01311 Clotrimazole,≥99%(Assay)Antibiotic ≥99%(Assay) 100G $343.62 2021-12-16 Buy
Chem-Impex 01311 Clotrimazole,≥99%(Assay)Antibiotic ≥99%(Assay) 25G $93.18 2021-12-16 Buy
Chem-Impex 01311 Clotrimazole,≥99%(Assay)Antibiotic ≥99%(Assay) 5G $29.12 2021-12-16 Buy
Chem-Impex 01311 Clotrimazole,≥99%(Assay)Antibiotic ≥99%(Assay) 1G $17.47 2021-12-16 Buy

Properties

Melting point :147-149°C
Boiling point :501.14°C (rough estimate)
Density :1.1095 (rough estimate)
refractive index :1.5940 (estimate)
storage temp. :2-8°C
solubility :Soluble in chloroform, DMSO, DMF and alcohols
pka :pKa 4.7(EtOH 50%aq ) (Uncertain)
form :Solid
color :White to Almost white
Water Solubility :<10mg/L(25 ºC)
λmax :556nm(Phosphate buffer sol.)(lit.)
Merck :14,2417
InChI :InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey :VNFPBHJOKIVQEB-UHFFFAOYSA-N
SMILES :C1N(C(C2=CC=CC=C2Cl)(C2=CC=CC=C2)C2=CC=CC=C2)C=CN=1
NIST Chemistry Reference :Clotrimazole(23593-75-1)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Clotrimazole is an imidazole antifungal that is active against a wide variety of fungal forms and is effective in many types of fungal infections. It tightly binds sterol 14-α demethylase isoform B from A. fumigatus (KD = 103 nM) and, like other imidazoles, disturbs the fungal cell membrane. In mammalian cells, clotrimazole potently inhibits the calcium-dependent potassium channels Kv1.3 and IK-1 (IC50 = 6.0 and 0.07 μM, respectively).

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