Clotrimazole is an orally applicable antifungal substance with broad-spectrum activity. Clotrimazole inhibits the microsomal cytochrome P450 (CYP450)-dependent event 14-α- lanosterol demethylation, which is a vital step in ergosterol biosynthesis by fungi. Moreover, Clotrimazole is a strong inhibitor of epidermal polycyclic aromatic hydrocarbon (PAH) carcinogen metabolism, of the enzyme-mediated binding of PAH to DNA, and of PAH-induced skin cancer. Also, Clotrimazole is a potent inhibitor of epoxide hydrolase activity in vitro with an IC50 value of 0.1 mM.

KEYWORDS: Clotrimazole | supplier | Antifungal agent | BAY b 5097 | BAYb 5097 | BAY-b 5097 | CAS [23593-75-1] | Steroid (Lanosterol 14-α) | Cytochrome P450 | Inhibitor | Enzymes | Polycyclic aromatic hydrocarbon cancer | PAH