CUCURBITACIN I
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- $65 - $1440
- Product name: CUCURBITACIN I
- CAS: 2222-07-3
- MF: C30H42O7
- MW: 514.65
- EINECS:218-736-8
- MDL Number:MFCD09971044
- Synonyms:ELATERICIN B;ELATERIN B;CUCURBITACIN I WITH HPLC;Cucurbitacin I hydrate;Elatericin B, JSI-124, NSC 521777, 2,16α,20,25-Tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione;(9β,10α,23E)-2,16α,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione;Ibamarin;2,16a,20,25-Tetrahydroxy-9b-methyl-10a-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
29 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 10mg
- 1
- 1mg
- 2mg
- 25mg
- 10mM(in 1mL DMSO)
- 20mg
- 100mg
- ManufacturerAK Scientific
- Product number8596CN
- Product descriptionCucurbitacinI
- Packaging5mg
- Price$363
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0028941
- Product descriptionCUCURBITACIN I 95.00%
- Packaging5MG
- Price$1103.54
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4512
- Product descriptionCucurbitacinI
- Packaging1mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4512
- Product descriptionCucurbitacinI
- Packaging5mg
- Price$285
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4512
- Product descriptionCucurbitacinI
- Packaging10mM(in 1mL DMSO)
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4512
- Product descriptionCucurbitacinI
- Packaging10mg
- Price$475
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN70316
- Product descriptionCucurbitacinI
- Packaging5mg
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb594564
- Product descriptionCucurbitacin I
- Packaging20mg
- Price$579.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb594564
- Product descriptionCucurbitacin I
- Packaging100mg
- Price$1356.6
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC64989
- Product descriptionCucurbitacin I
- Packaging1mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC64989
- Product descriptionCucurbitacin I
- Packaging2mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC64989
- Product descriptionCucurbitacin I
- Packaging5mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC64989
- Product descriptionCucurbitacin I
- Packaging10mg
- Price$620
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC64989
- Product descriptionCucurbitacin I
- Packaging25mg
- Price$1200
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14747
- Product descriptionCucurbitacin I ≥98%
- Packaging1mg
- Price$96
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14747
- Product descriptionCucurbitacin I ≥98%
- Packaging5mg
- Price$238
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 8596CN | CucurbitacinI | 5mg | $363 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0028941 | CUCURBITACIN I 95.00% | 5MG | $1103.54 | 2021-12-16 | Buy |
| ApexBio Technology | A4512 | CucurbitacinI | 1mg | $65 | 2021-12-16 | Buy |
| ApexBio Technology | A4512 | CucurbitacinI | 5mg | $285 | 2021-12-16 | Buy |
| ApexBio Technology | A4512 | CucurbitacinI | 10mM(in 1mL DMSO) | $470 | 2021-12-16 | Buy |
| ApexBio Technology | A4512 | CucurbitacinI | 10mg | $475 | 2021-12-16 | Buy |
| Arctom | CFN70316 | CucurbitacinI | 5mg | $288 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb594564 | Cucurbitacin I | 20mg | $579.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb594564 | Cucurbitacin I | 100mg | $1356.6 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC64989 | Cucurbitacin I | 1mg | $125 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC64989 | Cucurbitacin I | 2mg | $200 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC64989 | Cucurbitacin I | 5mg | $400 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC64989 | Cucurbitacin I | 10mg | $620 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC64989 | Cucurbitacin I | 25mg | $1200 | 2021-12-16 | Buy |
| Cayman Chemical | 14747 | Cucurbitacin I ≥98% | 1mg | $96 | 2024-03-01 | Buy |
| Cayman Chemical | 14747 | Cucurbitacin I ≥98% | 5mg | $238 | 2024-03-01 | Buy |
Properties
Melting point :148-150°C
Boiling point :698.3±55.0 °C(Predicted)
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥22.45 mg/mL in DMSO; insoluble in EtOH; ≥51.2 mg/mL in H2O with ultrasonic
pka :8.51±0.70(Predicted)
form :solid
color :white to off-white
LogP :2.330 (est)
Boiling point :698.3±55.0 °C(Predicted)
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥22.45 mg/mL in DMSO; insoluble in EtOH; ≥51.2 mg/mL in H2O with ultrasonic
pka :8.51±0.70(Predicted)
form :solid
color :white to off-white
LogP :2.330 (est)
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Cucurbitacin I is triterpenoid compound that acts as a potent inhibitor of the STAT3/JAK signaling pathway. It specifically suppresses levels of tyrosine phosphorylated STAT3 in v-Src-transformed NIH 3T3 cells and in A549 cells (IC50 = 500 nM) resulting in inhibition of STAT3 DNA binding and reduced STAT3-mediated gene transcription. It also suppresses JAK2 phosphorylation but does not affect Src, ERK, JNK or Akt. In nude mice, cucurbitacin I(1 mg/kg/day) suppressed growth of various tumors expressing constitutively active STAT3. It promotes the differentiation of dendritic cells and macrophages and enhances the effect of cancer immunotherapy. Cucubitacin I (1 μM for 2 hours) reduced clonogenicity of nasopharyngeal carcinoma cells in vitro and suppresses tumor growth in mice (1.3 mg/kg).
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