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ChemicalBook >> CAS DataBase List >> CPI-444

CPI-444

CPI-444 price.
  • $44 - $2500
  • Product name: CPI-444
  • CAS: 1202402-40-1
  • MF: C20H21N7O3
  • MW: 407.43
  • EINECS:-0
  • MDL Number:MFCD31540410
  • Synonyms:(S)-7-(5-Methyl-furan-2-yl)-3-[6-(tetrahydro-furan-3-yloxyMethyl)-pyridin-2-ylMethyl]-3H-[1,2,3]triazolo[4,5-d]pyriMidin-5-ylaMine;CPD1110;CPI-444;7-(5-Methyl-2-furanyl)-3-[[6-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine;Triazolo-pyramidine derivative;3H-1,2,3-Triazolo[4,5-d]pyrimidin-5-amine, 7-(5-methyl-2-furanyl)-3-[[6-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-;CPI-444 AND7648;(S)-5-Amino-7-(5-methyl-2-furyl)-3-[[6-[[(3-tetrahydrofuranyl)oxy]methyl]-2-pyridyl]methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidine
15 prices
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Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • ManufacturerAK Scientific
  • Product number3392DF
  • Product descriptionCiforadenant
  • Packaging1mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3392DF
  • Product descriptionCiforadenant
  • Packaging10mg
  • Price$407
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0005711
  • Product description(S)-7-(5-METHYLFURAN-2-YL)-3-((6-(((TETRAHYDROFURAN-3-YL)OXY)METHYL)PYRIDIN-2-YL)METHYL)-3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-5-AMINE 95.00%
  • Packaging5MG
  • Price$454.51
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number25024
  • Product descriptionCPI-444 ≥98%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25024
  • Product descriptionCPI-444 ≥98%
  • Packaging5mg
  • Price$151
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25024
  • Product descriptionCPI-444 ≥98%
  • Packaging10mg
  • Price$278
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25024
  • Product descriptionCPI-444 ≥98%
  • Packaging25mg
  • Price$638
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7627
  • Product descriptionCPI-444 99.94%
  • Packaging5mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7627
  • Product descriptionCPI-444 99.94%
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7627
  • Product descriptionCPI-444 99.94%
  • Packaging50mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7627
  • Product descriptionCPI-444 99.94%
  • Packaging100mg
  • Price$750
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10527
  • Product descriptionCPI-444 >98%
  • Packaging100mg
  • Price$700
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10527
  • Product descriptionCPI-444 >98%
  • Packaging1g
  • Price$2500
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberC781455
  • Product descriptionCPI-444
  • Packaging25mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberC781455
  • Product descriptionCPI-444
  • Packaging100mg
  • Price$1040
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3392DF Ciforadenant 1mg $147 2021-12-16 Buy
AK Scientific 3392DF Ciforadenant 10mg $407 2021-12-16 Buy
American Custom Chemicals Corporation INB0005711 (S)-7-(5-METHYLFURAN-2-YL)-3-((6-(((TETRAHYDROFURAN-3-YL)OXY)METHYL)PYRIDIN-2-YL)METHYL)-3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-5-AMINE 95.00% 5MG $454.51 2021-12-16 Buy
Cayman Chemical 25024 CPI-444 ≥98% 1mg $44 2024-03-01 Buy
Cayman Chemical 25024 CPI-444 ≥98% 5mg $151 2024-03-01 Buy
Cayman Chemical 25024 CPI-444 ≥98% 10mg $278 2024-03-01 Buy
Cayman Chemical 25024 CPI-444 ≥98% 25mg $638 2024-03-01 Buy
ChemScene CS-7627 CPI-444 99.94% 5mg $100 2021-12-16 Buy
ChemScene CS-7627 CPI-444 99.94% 10mg $150 2021-12-16 Buy
ChemScene CS-7627 CPI-444 99.94% 50mg $450 2021-12-16 Buy
ChemScene CS-7627 CPI-444 99.94% 100mg $750 2021-12-16 Buy
DC Chemicals DC10527 CPI-444 >98% 100mg $700 2021-12-16 Buy
DC Chemicals DC10527 CPI-444 >98% 1g $2500 2021-12-16 Buy
TRC C781455 CPI-444 25mg $450 2021-12-16 Buy
TRC C781455 CPI-444 100mg $1040 2021-12-16 Buy

Properties

Melting point :169-171°C
Boiling point :676.9±65.0 °C(Predicted)
Density :1.55±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :solid
pka :4.05±0.30(Predicted)
color :Beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

CPI-444 (1202402-40-1) is a potent (Ki = 3.54 nM) and selective adenosine A2A receptor antagonist. It blocked the induction of cAMP induced by NECA in HEK-293 cells with an IC50 = 17.03 nM. CPI-444 monotherapy or in combination with anti-PD-1, anti-PD-L1, and anti-CTLA-4 induced T-cell-mediated tumor responses, inhibited tumor growth, and enabled antitumor immune memory. Currently in clinical trials for multiple cancers.

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