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ChemicalBook >> CAS DataBase List >> CH5138303

CH5138303

CH5138303 price.
  • $67 - $404
  • Product name: CH5138303
  • CAS: 959763-06-5
  • MF: C19H18ClN5O2S
  • MW: 415.9
  • EINECS:
  • MDL Number:MFCD28099815
  • Synonyms:CH5138303;Butanamide, 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]-;4-[(4-Amino-6-[7-chloro-3-oxatricyclo[7.3.1.0(5,13)] trideca-1(13),5,7,9,11-pentaen-8-yl]-1,3,5-triazin-2-yl)sulfanyl]butanamide;4-[[4-Amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]butanamide;4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamid;CH5138303_Hsp90;4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-ylsulfanyl]butanamide;CH5138303 USP/EP/BP
6 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
Package
  • 10mM(in 1mL DMSO)
  • 1mg
  • 5mg
  • ManufacturerAK Scientific
  • Product number2164AH
  • Product description4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[DE]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamide
  • Packaging1mg
  • Price$228
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4571
  • Product descriptionCH5138303
  • Packaging1mg
  • Price$67
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4571
  • Product descriptionCH5138303
  • Packaging5mg
  • Price$237
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4571
  • Product descriptionCH5138303
  • Packaging10mM(in 1mL DMSO)
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number22417
  • Product descriptionCH5138303 ≥99%
  • Packaging5mg
  • Price$404
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22417
  • Product descriptionCH5138303 ≥99%
  • Packaging1mg
  • Price$117
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2164AH 4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[DE]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamide 1mg $228 2021-12-16 Buy
ApexBio Technology B4571 CH5138303 1mg $67 2021-12-16 Buy
ApexBio Technology B4571 CH5138303 5mg $237 2021-12-16 Buy
ApexBio Technology B4571 CH5138303 10mM(in 1mL DMSO) $280 2021-12-16 Buy
Cayman Chemical 22417 CH5138303 ≥99% 5mg $404 2024-03-01 Buy
Cayman Chemical 22417 CH5138303 ≥99% 1mg $117 2024-03-01 Buy

Properties

Boiling point :813.1±75.0 °C(Predicted)
Density :1.51±0.1 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥19.95 mg/mL in DMSO
form :solid
pka :16.39±0.40(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

CH5138303 is a triazine Hsp90 inhibitor. CH5138303 binds to the N-terminus of Hsp90α (Kd = 0.52 nM) and inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro (IC50s = 89 and 66 nM, respectively). CH5138303 also inhibits growth of human NCI-N87 gastric cancer xenografts (ED50 = 3.9 mg/kg) and displays high oral bioavailability in mice.