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ChemicalBook >> CAS DataBase List >> 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER price.
  • $45 - $1680
  • Product name: 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • CAS: 571188-82-4
  • MF: C27H34BrN7O3
  • MW: 584.51
  • EINECS:1592732-453-0
  • MDL Number:MFCD09834002
  • Synonyms:4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Piperazinecarboxylic acid, 4-[6-[(6-broMo-8-cyclopentyl-7,8-dihydro-5-Methyl-7-oxopyrido[2,3-d]pyriMidin-2-yl)aMino]-3-pyridinyl]-, 1,1-diMethylethyl ester;tert-butyl 4-{6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl}piperazine-1-carboxylat;tert-butyl 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazine-1-carboxylate;tert-Butyl 4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl);Palbociclib Intermediate 4;Palbociclib-016;tert-butyl 4-[6-({6-bromo-8-cyclopentyl-5-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl}amino)pyrid
11 prices
Selected condition：
Brand
  • AK Scientific
  • Alichem
  • American Custom Chemicals Corporation
  • Crysdot
  • TRC
Package
  • 5MG
  • 25mg
  • 50mg
  • 250mg
  • 1g
  • 5g
  • ManufacturerAK Scientific
  • Product number5116CS
  • Product descriptionCID11157536
  • Packaging1g
  • Price$89
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number571188824
  • Product descriptiontert-Butyl4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
  • Packaging250mg
  • Price$291.04
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number571188824
  • Product descriptiontert-Butyl4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
  • Packaging1g
  • Price$686.8
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number571188824
  • Product descriptiontert-Butyl4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
  • Packaging5g
  • Price$1680
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberHCH0356662
  • Product description1,1-DIMETHYL-4-[6-[(6-BROMO-8-CYCLOPENTYL-7,8-DIHYDRO-5-METHYL-7-OXOPYRIDO[2,3-D]PYRIMIDIN-2-YL)AMINO]-3-PYRIDINYL]-1-PIPERAZINECARBOXYLIC ACID ETHYL ESTER 95.00%
  • Packaging5MG
  • Price$501.07
  • Updated2021-12-16
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  • ManufacturerCrysdot
  • Product numberCD11102435
  • Product descriptiontert-Butyl4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 97%
  • Packaging250mg
  • Price$269
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11102435
  • Product descriptiontert-Butyl4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 97%
  • Packaging1g
  • Price$673
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11102435
  • Product descriptiontert-Butyl4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 97%
  • Packaging5g
  • Price$1664
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberD445873
  • Product description6-Desacetyl-6-bromo-N-BocPalbociclib
  • Packaging25mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberD445873
  • Product description6-Desacetyl-6-bromo-N-BocPalbociclib
  • Packaging50mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberD445873
  • Product description6-Desacetyl-6-bromo-N-BocPalbociclib
  • Packaging250mg
  • Price$405
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5116CS CID11157536 1g $89 2021-12-16 Buy
Alichem 571188824 tert-Butyl4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 250mg $291.04 2021-12-16 Buy
Alichem 571188824 tert-Butyl4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 1g $686.8 2021-12-16 Buy
Alichem 571188824 tert-Butyl4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 5g $1680 2021-12-16 Buy
American Custom Chemicals Corporation HCH0356662 1,1-DIMETHYL-4-[6-[(6-BROMO-8-CYCLOPENTYL-7,8-DIHYDRO-5-METHYL-7-OXOPYRIDO[2,3-D]PYRIMIDIN-2-YL)AMINO]-3-PYRIDINYL]-1-PIPERAZINECARBOXYLIC ACID ETHYL ESTER 95.00% 5MG $501.07 2021-12-16 Buy
Crysdot CD11102435 tert-Butyl4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 97% 250mg $269 2021-12-16 Buy
Crysdot CD11102435 tert-Butyl4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 97% 1g $673 2021-12-16 Buy
Crysdot CD11102435 tert-Butyl4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 97% 5g $1664 2021-12-16 Buy
TRC D445873 6-Desacetyl-6-bromo-N-BocPalbociclib 25mg $45 2021-12-16 Buy
TRC D445873 6-Desacetyl-6-bromo-N-BocPalbociclib 50mg $90 2021-12-16 Buy
TRC D445873 6-Desacetyl-6-bromo-N-BocPalbociclib 250mg $405 2021-12-16 Buy

Properties

Melting point :>250℃
Boiling point :720.0±70.0 °C(Predicted)
Density :1.439±0.06 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
pka :5.24±0.10(Predicted)
InChIKey :UTSOLZWQDXJQRH-UHFFFAOYSA-N
SMILES :N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(NC3=NC=C4C(C)=C(Br)C(=O)N(C5CCCC5)C4=N3)N=C2)CC1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

6-Desacetyl-6-bromo-N-Boc Palbociclib is an impurity of Palbociclib (P139900),(also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.Also, it is derived from 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one (B682195), which is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.