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ChemicalBook >> CAS DataBase List >> Vonoprazan fumarate

Vonoprazan fumarate

Vonoprazan fumarate price.
  • $43 - $2348
  • Product name: Vonoprazan fumarate
  • CAS: 1260141-27-2
  • MF: C21H20FN3O6S
  • MW: 461.4634032
  • EINECS:250-635-4
  • MDL Number:MFCD18633280
  • Synonyms:1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine;AK-438;vonoprazan(tak-438);fuMarate vonoprazan;1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-, 2-butenedioate (1:1);5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate TAK 438;vonaprazan(TK-438);TAK-438 Vonoprazan fumarate
17 prices
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Brand
  • AK Scientific
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Usbiological
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • 5g
  • 10g
  • ManufacturerAK Scientific
  • Product numberJ97352
  • Product descriptionTAK-438
  • Packaging5g
  • Price$315
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA2308
  • Product descriptionTAK-438
  • Packaging5mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA2308
  • Product descriptionTAK-438
  • Packaging25mg
  • Price$600
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFT102406
  • Product descriptionTAK 438
  • Packaging10mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFT102406
  • Product descriptionTAK 438
  • Packaging50mg
  • Price$787.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number24200
  • Product descriptionVonoprazan (fumarate) ≥98%
  • Packaging500mg
  • Price$43
  • Updated2023-06-20
  • Buy
  • ManufacturerCayman Chemical
  • Product number24200
  • Product descriptionVonoprazan (fumarate) ≥98%
  • Packaging1g
  • Price$76
  • Updated2023-06-20
  • Buy
  • ManufacturerCayman Chemical
  • Product number24200
  • Product descriptionVonoprazan (fumarate) ≥98%
  • Packaging5g
  • Price$293
  • Updated2023-06-20
  • Buy
  • ManufacturerCayman Chemical
  • Product number24200
  • Product descriptionVonoprazan (fumarate) ≥98%
  • Packaging10g
  • Price$417
  • Updated2023-06-20
  • Buy
  • ManufacturerChemenu
  • Product numberCM176408
  • Product description1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanaminefumarate 97%
  • Packaging100mg
  • Price$1257
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004062
  • Product descriptionTAK-438 98+%
  • Packaging5mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004062
  • Product descriptionTAK-438 98+%
  • Packaging10mg
  • Price$278
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004062
  • Product descriptionTAK-438 98+%
  • Packaging25mg
  • Price$435
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7306
  • Product descriptionTAK-438 >98%
  • Packaging250mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerMatrix Scientific
  • Product number145190
  • Product description1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate 95%
  • Packaging100mg
  • Price$1305
  • Updated2021-12-16
  • Buy
  • ManufacturerMatrix Scientific
  • Product number145190
  • Product description1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate 95%
  • Packaging250mg
  • Price$2348
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J97352 TAK-438 5g $315 2021-12-16 Buy
ApexBio Technology A2308 TAK-438 5mg $200 2021-12-16 Buy
ApexBio Technology A2308 TAK-438 25mg $600 2021-12-16 Buy
Biosynth Carbosynth FT102406 TAK 438 10mg $225 2021-12-16 Buy
Biosynth Carbosynth FT102406 TAK 438 50mg $787.5 2021-12-16 Buy
Cayman Chemical 24200 Vonoprazan (fumarate) ≥98% 500mg $43 2023-06-20 Buy
Cayman Chemical 24200 Vonoprazan (fumarate) ≥98% 1g $76 2023-06-20 Buy
Cayman Chemical 24200 Vonoprazan (fumarate) ≥98% 5g $293 2023-06-20 Buy
Cayman Chemical 24200 Vonoprazan (fumarate) ≥98% 10g $417 2023-06-20 Buy
Chemenu CM176408 1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanaminefumarate 97% 100mg $1257 2021-12-16 Buy
Crysdot CD31004062 TAK-438 98+% 5mg $210 2021-12-16 Buy
Crysdot CD31004062 TAK-438 98+% 10mg $278 2021-12-16 Buy
Crysdot CD31004062 TAK-438 98+% 25mg $435 2021-12-16 Buy
DC Chemicals DC7306 TAK-438 >98% 250mg $500 2021-12-16 Buy
Matrix Scientific 145190 1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate 95% 100mg $1305 2021-12-16 Buy
Matrix Scientific 145190 1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate 95% 250mg $2348 2021-12-16 Buy

Properties

storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥18.9 mg/mL in DMSO
form :solid
InChIKey :ROGSHYHKHPCCJW-WLHGVMLRSA-N
SMILES :N1(S(C2=CC=CN=C2)(=O)=O)C(C2=CC=CC=C2F)=CC(CNC)=C1.C(O)(=O)/C=C/C(O)=O

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Vonoprazan fumarate (Takecab®), discovered and developed by Takeda and Otsuka, was approved by the PMDA of Japan in December 2014, and is indicated for the treatment of gastric ulcer, duodenal ulcer and reflux esophagitis. Vonoprazan fumarate has a novel mechanism of action called potassium-competitive acid blockers, which competitively inhibit the binding of potassium ions to H+, K+-ATPase (also known as the proton pump) in the final step of gastric acid secretion in gastric parietal cells. Vonoprazan does not inhibit Na+, K+-ATPase activity even at concentrations 500 times higher than that of their IC50 values against gastric H+, K+-ATPase activity. Furthermore, the drug is unaffected by the gastric secretory state, unlike PPIs.

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