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ChemicalBook >> CAS DataBase List >> cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid price.
  • $28 - $2700
  • Product name: cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid
  • CAS: 471905-41-6
  • MF: C21H21ClF2O4S
  • MW: 442.9
  • EINECS:
  • MDL Number:MFCD21608529
  • Synonyms:MK-0752, >=98%;Cyclohexanepropanoic acid, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, cis-;MK-0752/MK0752;3-(cis-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid;3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid;cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid MK-0752;cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid;CS-10
26 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Labseeker
  • Matrix Scientific
  • Medical Isotopes, Inc.
Package
  • 10mg
  • 50mg
  • 250mg
  • 1g
  • 10mM(in 1mL DMSO)
  • 1MG
  • 1unit
  • 5MG
  • 100mg
  • ManufacturerAK Scientific
  • Product numberX7591
  • Product description3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoicacid
  • Packaging100mg
  • Price$2431
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004452
  • Product descriptionMK-0752 95.00%
  • Packaging1MG
  • Price$173.25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004452
  • Product descriptionMK-0752 95.00%
  • Packaging5MG
  • Price$500.15
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4006
  • Product descriptionMK-0752
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4006
  • Product descriptionMK-0752
  • Packaging5mg
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4006
  • Product descriptionMK-0752
  • Packaging10mM(in 1mL DMSO)
  • Price$220
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4006
  • Product descriptionMK-0752
  • Packaging10mg
  • Price$230
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4006
  • Product descriptionMK-0752
  • Packaging50mg
  • Price$590
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4006
  • Product descriptionMK-0752
  • Packaging100mg
  • Price$1080
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60449
  • Product descriptionMK-0752 ≥98%
  • Packaging5mg
  • Price$358
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16706
  • Product descriptionMK-0752 ≥98%
  • Packaging1mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16706
  • Product descriptionMK-0752 ≥98%
  • Packaging5mg
  • Price$302
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16706
  • Product descriptionMK-0752 ≥98%
  • Packaging10mg
  • Price$435
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM202948
  • Product description3-(cis-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoicacid 98%
  • Packaging100mg
  • Price$715
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0253
  • Product descriptionMK-0752 98.00%
  • Packaging5mg
  • Price$238
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0253
  • Product descriptionMK-0752 98.00%
  • Packaging10mg
  • Price$311
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7591 3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoicacid 100mg $2431 2021-12-16 Buy
American Custom Chemicals Corporation INB0004452 MK-0752 95.00% 1MG $173.25 2021-12-16 Buy
American Custom Chemicals Corporation INB0004452 MK-0752 95.00% 5MG $500.15 2021-12-16 Buy
ApexBio Technology A4006 MK-0752 1unit $28 2021-12-16 Buy
ApexBio Technology A4006 MK-0752 5mg $170 2021-12-16 Buy
ApexBio Technology A4006 MK-0752 10mM(in 1mL DMSO) $220 2021-12-16 Buy
ApexBio Technology A4006 MK-0752 10mg $230 2021-12-16 Buy
ApexBio Technology A4006 MK-0752 50mg $590 2021-12-16 Buy
ApexBio Technology A4006 MK-0752 100mg $1080 2021-12-16 Buy
Arctom CFN60449 MK-0752 ≥98% 5mg $358 2021-12-16 Buy
Cayman Chemical 16706 MK-0752 ≥98% 1mg $68 2024-03-01 Buy
Cayman Chemical 16706 MK-0752 ≥98% 5mg $302 2024-03-01 Buy
Cayman Chemical 16706 MK-0752 ≥98% 10mg $435 2024-03-01 Buy
Chemenu CM202948 3-(cis-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoicacid 98% 100mg $715 2021-12-16 Buy
ChemScene CS-0253 MK-0752 98.00% 5mg $238 2021-12-16 Buy
ChemScene CS-0253 MK-0752 98.00% 10mg $311 2021-12-16 Buy

Properties

Melting point :166.6-167.5 °C(Solv: isopropyl acetate (108-21-4); heptane (142-82-5))
Boiling point :616.9±55.0 °C(Predicted)
Density :1.361
storage temp. :Store at -20°C
solubility :≥22.15 mg/mL in DMSO; insoluble in H2O; ≥48.8 mg/mL in EtOH with ultrasonic
form :Powder
pka :4.76±0.10(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P501 Dispose of contents/container to..…

Description

γ-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and β-amyloid precursor protein (APP), within the transmembrane domain. MK-0752 is a potent, reversible inhibitor of γ-secretase, reducing the cleavage of APP to Aβ40 in human neuroblastoma SH-SY5Y cells with an IC50 value of 5 nM. It is orally bioavailable and crosses the blood-brain barrier, as orally administered MK-0752 dose-dependently reduces the generation of new amyloid β protein in the brain of rhesus monkeys. Through its effects on the Notch pathway, MK-0752 reduces the number of breast cancer stem cells in tumorgrafts, enhancing the efficacy of the chemotherapy drug docetaxel in mice with breast cancer tumors.

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