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ChemicalBook >> CAS DataBase List >> DAPT

DAPT

DAPT price.
  • $28 - $2776
  • Product name: DAPT
  • CAS: 208255-80-5
  • MF: C23H26F2N2O4
  • MW: 432.46
  • EINECS:
  • MDL Number:MFCD04974585
  • Synonyms:LY-374973, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester;N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethylester;SC-201315;(2S)-N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester;DAPT (enzyme inhibitor);GSI-IX;γ-Secretase Inhibitor IX;tert-butyl (2R)-[((2S)-2-{[(3,5-difluorophenyl)acetyl]aMino}propanoyl)aMino](phenyl)ethanoate
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  • Activate Scientific
  • Adipogen Life Sciences
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  • Cayman Chemical
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Package
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  • 5mg
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  • 250mg
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  • 1g
  • 5g
  • 10mM(in 1mL DMSO)
  • ManufacturerActivate Scientific
  • Product numberAS116025
  • Product descriptionDAPT 98+%
  • Packaging5mg
  • Price$134
  • Updated2021-12-16
  • Buy
  • ManufacturerActivate Scientific
  • Product numberAS116025
  • Product descriptionDAPT 98+%
  • Packaging25mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-0016-M025
  • Product descriptionDAPT ≥98%(NMR)
  • Packaging25mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7572
  • Product descriptionDAPT
  • Packaging25mg
  • Price$458
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ96086
  • Product descriptionDAPT
  • Packaging10mg
  • Price$115
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ65864
  • Product descriptionDAPT
  • Packaging10mg
  • Price$227
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA150458
  • Product descriptionDAPT 98+%
  • Packaging5mg
  • Price$39
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150458
  • Product descriptionDAPT 98+%
  • Packaging10mg
  • Price$51
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150458
  • Product descriptionDAPT 98+%
  • Packaging25mg
  • Price$66
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150458
  • Product descriptionDAPT 98+%
  • Packaging50mg
  • Price$86
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150458
  • Product descriptionDAPT 98+%
  • Packaging100mg
  • Price$109
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150458
  • Product descriptionDAPT 98+%
  • Packaging250mg
  • Price$157
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA150458
  • Product descriptionDAPT 98+%
  • Packaging1g
  • Price$408
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8200
  • Product descriptionDAPT(GSI-IX)
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8200
  • Product descriptionDAPT(GSI-IX)
  • Packaging10mM(in 1mL DMSO)
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8200
  • Product descriptionDAPT(GSI-IX)
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Activate Scientific AS116025 DAPT 98+% 5mg $134 2021-12-16 Buy
Activate Scientific AS116025 DAPT 98+% 25mg $280 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-0016-M025 DAPT ≥98%(NMR) 25mg $200 2021-12-16 Buy
AK Scientific X7572 DAPT 25mg $458 2021-12-16 Buy
AK Scientific J96086 DAPT 10mg $115 2021-12-16 Buy
Alfa Aesar J65864 DAPT 10mg $227 2024-03-01 Buy
Ambeed A150458 DAPT 98+% 5mg $39 2021-12-16 Buy
Ambeed A150458 DAPT 98+% 10mg $51 2021-12-16 Buy
Ambeed A150458 DAPT 98+% 25mg $66 2021-12-16 Buy
Ambeed A150458 DAPT 98+% 50mg $86 2021-12-16 Buy
Ambeed A150458 DAPT 98+% 100mg $109 2021-12-16 Buy
Ambeed A150458 DAPT 98+% 250mg $157 2021-12-16 Buy
Ambeed A150458 DAPT 98+% 1g $408 2021-12-16 Buy
ApexBio Technology A8200 DAPT(GSI-IX) 1unit $28 2021-12-16 Buy
ApexBio Technology A8200 DAPT(GSI-IX) 10mM(in 1mL DMSO) $60 2021-12-16 Buy
ApexBio Technology A8200 DAPT(GSI-IX) 10mg $70 2021-12-16 Buy

Properties

alpha :+40.0~+47.0°(D/20℃)(c=0.5,DMSO)
Boiling point :612.2±55.0 °C(Predicted)
Density :1.213
storage temp. :2-8°C
solubility :DMSO: ~18 mg/mL
form :solid
pka :12.82±0.46(Predicted)
color :white
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :DWJXYEABWRJFSP-XOBRGWDASA-N
CAS DataBase Reference :208255-80-5

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P501 Dispose of contents/container to..…

Description

γ-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Aβ), a 39- to 42-amino acid peptide which forms the amyloid plaques that are characteristic of Alzheimer’s disease. DAPT is an inhibitor of γ-secretase, blocking the production of total Aβ in human primary neuronal cultures with an IC50 value of 115 nM and Aβ42 with an IC50 value of 200 nM. DAPT is also effective in vivo, reducing brain levels of Aβ when given orally to mice that are transgenic for human APPV717F or to rats. Through its effects on γ-secretase, DAPT indirectly inhibits Notch, affecting cell signaling and cell differentiation.

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