4',6'-DIMETHOXY-2'-HYDROXYCHALCONE
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- $34 - $903.95
- Product name: 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE
- CAS: 1775-97-9
- MF: C17H16O4
- MW: 284.31
- EINECS:
- MDL Number:MFCD00075877
- Synonyms:CARDAMONIN-4'-METHYL ETHER;FLAVOKAWAIN B;FLAVOKAWIN B;DIMETHOXY-2'-HYDROXYCHALCONE, 4',6'-;(E)-1-(2-HYDROXY-4,6-DIMETHOXY-PHENYL)-3-PHENYL-PROPENONE;4',6'-DIMETHOXY-2'-HYDROXYCHALCONE;1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one) ;(E)-1-(2-Hydroxy-4,6-dimethoxy-phenyl)-3-phenyl-
25 prices
Selected condition：
Brand
- AHH
- AK Scientific
- Alichem
- American Custom Chemicals Corporation
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Crysdot
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 500μg
- 1mg
- 2mg
- 5mg
- 10mg
- 20mg
- 25mg
- 0.1g
- 250mg
- 1g
- ManufacturerAHH
- Product numberMT-14983
- Product description(E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3phenylpropenone 98%
- Packaging0.1g
- Price$475
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY2024
- Product description2',4'-dimethoxy-6'-hydroxychalcone
- Packaging5mg
- Price$232
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number1775979
- Product description(E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
- Packaging10mg
- Price$245
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number1775979
- Product description(E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
- Packaging250mg
- Price$375.9
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number1775979
- Product description(E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
- Packaging1g
- Price$903.95
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002706
- Product description4',6'-DIMETHOXY-2'-HYDROXYCHALCONE 95.00%
- Packaging5MG
- Price$713.26
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002706
- Product description4',6'-DIMETHOXY-2'-HYDROXYCHALCONE 95.00%
- Packaging10MG
- Price$754.46
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN92661
- Product descriptionFlavokawainB ≥98%
- Packaging20mg
- Price$158
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3337
- Product descriptionFlavokavain B
- Packaging5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3337
- Product descriptionFlavokavain B
- Packaging10mg
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3337
- Product descriptionFlavokavain B
- Packaging25mg
- Price$369
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb259236
- Product descriptionFlavokawain B 98%
- Packaging20mg
- Price$375.7
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD66669
- Product description4',6'-Dimethoxy-2'-hydroxychalcone
- Packaging2mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD66669
- Product description4',6'-Dimethoxy-2'-hydroxychalcone
- Packaging5mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD66669
- Product description4',6'-Dimethoxy-2'-hydroxychalcone
- Packaging10mg
- Price$240
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD66669
- Product description4',6'-Dimethoxy-2'-hydroxychalcone
- Packaging25mg
- Price$537.5
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AHH | MT-14983 | (E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3phenylpropenone 98% | 0.1g | $475 | 2021-12-16 | Buy |
| AK Scientific | Y2024 | 2',4'-dimethoxy-6'-hydroxychalcone | 5mg | $232 | 2021-12-16 | Buy |
| Alichem | 1775979 | (E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one | 10mg | $245 | 2021-12-16 | Buy |
| Alichem | 1775979 | (E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one | 250mg | $375.9 | 2021-12-16 | Buy |
| Alichem | 1775979 | (E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one | 1g | $903.95 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002706 | 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE 95.00% | 5MG | $713.26 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002706 | 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE 95.00% | 10MG | $754.46 | 2021-12-16 | Buy |
| Arctom | CFN92661 | FlavokawainB ≥98% | 20mg | $158 | 2021-12-16 | Buy |
| AvaChem | 3337 | Flavokavain B | 5mg | $95 | 2021-12-16 | Buy |
| AvaChem | 3337 | Flavokavain B | 10mg | $189 | 2021-12-16 | Buy |
| AvaChem | 3337 | Flavokavain B | 25mg | $369 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb259236 | Flavokawain B 98% | 20mg | $375.7 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD66669 | 4',6'-Dimethoxy-2'-hydroxychalcone | 2mg | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD66669 | 4',6'-Dimethoxy-2'-hydroxychalcone | 5mg | $135 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD66669 | 4',6'-Dimethoxy-2'-hydroxychalcone | 10mg | $240 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD66669 | 4',6'-Dimethoxy-2'-hydroxychalcone | 25mg | $537.5 | 2021-12-16 | Buy |
Properties
Melting point :85-87°C
Boiling point :500.1±50.0 °C(Predicted)
Density :1.203±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :6.84±0.40(Predicted)
form :Solid
color :Yellow to Dark Yellow
LogP :4.206 (est)
CAS DataBase Reference :1775-97-9(CAS DataBase Reference)
Boiling point :500.1±50.0 °C(Predicted)
Density :1.203±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :6.84±0.40(Predicted)
form :Solid
color :Yellow to Dark Yellow
LogP :4.206 (est)
CAS DataBase Reference :1775-97-9(CAS DataBase Reference)
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Flavokawain B is a natural chalcone first isolated from extracts of kava roots. It induces apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50s = 32, 48, 6.2, and 3.9 μM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours), with increased expression of the proapoptotic protein Bim. Flavokawain B increases Bim expression and inhibits growth of DU145 xenografts in mice. It also increases Bim expression, promotes apoptosis, and induces cell cycle arrest in uterine leiomyosarcoma cells. However, flavokawain B is hepatotoxic, triggering oxidative stress, inhibiting NF-κB signaling, and activating MAPK pathways, culminating in HepG2 and L-02 cell death (LD50s = 15 and 32 μM, respectively).Related product price
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Suppliers and manufacturers
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sgtlifesciences pvt ltd
