Pyridine
Product identifier
- Product name: Pyridine
- CBnumber: CB8852825
- CAS: 110-86-1
- EINECS Number: 203-809-9
- Synonyms: pyridine,Py
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: Pyridine
- Synonyms: pyridine,Py
- CAS: 110-86-1
- EC number: 203-809-9
- MF: C5H5N
- MW: 79.1
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Notes to physician
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx) Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.
Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 3 | Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.
Environmental precautions
Do not let product enter drains. Risk of explosion.
Methods and materials for containment and cleaning up
Large spills should be collected mechanically (remove by pumping) for disposal. Ventilate the area.Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g.
Chemizorb? ). Dispose of properly. Clean up affected area.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols. Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition.
Handle and store under inert gas.
control parameter
Hazard composition and occupational exposure limitsExposure controls
Appropriate engineering controlsImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Splash contact Material: butyl-rubber
Minimum layer thickness: 0.7 mm Break through time: 240 min Material tested:Butoject? (KCL 898)
Flame retardant antistatic protective clothing.
required when vapours/aerosols are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Do not let product enter drains. Risk of explosion.
Information on basic physicochemical properties
- Appearancecolorless liquid
- Odourpungent
- Odour Threshold0.0001 ppm
- pHca.8.81 at 20 °C
- Melting point/freezing pointMelting point/range: -42 °C - lit.
- Initial boiling point and boiling range 115 °C - lit.
- Flash point20 °C - closed cup - ISO 1523
- Evaporation rate12.7
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limits Upper explosion limit: 12.4 %(V) Lower explosion limit: 1.8 %(V)
- Vapour pressure ca.26.7 hPa at 25 °C
- Vapour density 2.73
- Relative density0.978 g/cm3 at 25 °C
- Water solubilityca.1,000 g/l at 20 °Csoluble
- Partition coefficient: n-octanol/waterlog Pow: ca.0.64 at 20 °C - (Lit.), Bioaccumulation is not expected.
- Autoignition temperature 900 °C at 1,013 hPa
- Decomposition temperature ca.490 °C -
- ViscosityNo data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
- Henry's Law Constant18.4 at 30 °C (headspace-GC, Chaintreau et al., 1995)
- λmaxλ: 305 nm Amax: 1.00
λ: 315 nm Amax: 0.15
λ: 335 nm Amax: 0.02
λ: 350-400 nm Amax: 0.01
Other safety information
Solubility in other solvents
Diethyl ether at 20 °C
-
miscible Ethanol at 20 °C
-
miscible
Surface tension 36.56 mN/m at 25 °C Dissociation constant 5.25 at 25 °C
Relative vapor density
2.73
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) . Stable under recommended storage conditions.
Possibility of hazardous reactions
No data available
Conditions to avoid
Warming.
Incompatible materials
Strong oxidizing agents, Strong acids
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx)
Other decomposition products - No data available In the event of fire: see section 5
Information on toxicological effects
Acute toxicityLC50 Inhalation - Rat - male - 4 h - 17.1 mg/l (US-EPA)
LD50 Dermal - Rabbit - > 1,000 - 2,000 mg/kg (OECD Test Guideline 402)
Result: Mild skin irritation - 24 h (Draize Test)
Result: Irritating to eyes. - 24 h Remarks: (ECHA)
Result: negative
(OECD Test Guideline 429)
Salmonella typhimurium Result: negative
In vitro mammalian cell gene mutation test Chinese hamster lung cells
Result: negative
OECD Test Guideline 475 Mouse - male - Bone marrow Result: negative
Acute inhalation toxicity - mucosal irritations, Cough, Shortness of breath
RTECS: UR8400000
burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea, Vomiting, Dizziness, tachycardia, nervousness, insomnia, Skin disorders, loss of appetite To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Systemic effects:
After uptake:
Headache
In high doses:
narcosis, cardiovascular disorders, Circulatory collapse Chronic uptake results in damage of:
Liver, Kidney
Good warning effect due to low odour threshold. Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Toxicity
(OECD Test Guideline 203)
Remarks: (in analogy to similar products)
EC50 - Daphnia magna (Water flea) - 320 mg/l - 48 h (OECD Test Guideline 202)
Remarks: (in analogy to similar products)
Remarks: (in analogy to similar products)
IC5 - Scenedesmus quadricauda (Green algae) - 120 mg/l - 7 d Remarks: (maximum permissible toxic concentration)(Lit.)
EC50 - SELENASTRUM - 100.00 - 180.00 mg/l - 72 h
Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 97 % - Readily biodegradable. (OECD Test Guideline 301B)
Bioaccumulative potential
Mobility in soil
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
No data available
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Violent reaction with strong oxidizers; strong acids; chlorosulfonic acid; maleic anhydride; oleum iodine.
Waste DisposalControlled incineration whereby nitrogen oxides are removed from the effluent gas by scrubber, catalytic or thermal devices .
UN number
ADR/RID: 1282 IMDG: 1282 IATA-DGR: 1282
UN proper shipping name
Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA-DGR: 3
Packaging group
ADR/RID: II IMDG: II IATA-DGR: II
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA-DGR: no
Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport. Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Incompatible materials
Strong oxidizing agents, Strong acids
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
Other Information
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.