p-Toluidine
Product identifier
- Product name: p-Toluidine
- CBnumber: CB8381150
- CAS: 106-49-0
- EINECS Number: 203-403-1
- Synonyms: P-toluidine,4-methylaniline
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: p-Toluidine
- Synonyms: P-toluidine,4-methylaniline
- CAS: 106-49-0
- EC number: 203-403-1
- MF: C7H9N
- MW: 107.15
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides Nitrogen oxides (NOx) Combustible.
Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Further information
Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible
only to qualified or authorized persons.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Personal protective equipmentUse equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU). Safety glasses
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm Break through time: 480 min
Material tested:KCL 741 Dermatril? L
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm Break through time: 480 min
Material tested:KCL 741 Dermatril? L
Flame retardant antistatic protective clothing.
Recommended Filter type: Filter A-(P3)
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Do not let product enter drains.
Information on basic physicochemical properties
- Appearancewhite crystalline
- Odouralcohol-like
- Odour ThresholdNo data available
- pHat 20 °C alkaline
- Melting point/freezing pointMelting point/range: 41 - 46 °C - lit.
- Initial boiling point and boiling range 200 °C - lit.
- Flash point87 °C - closed cup - DIN 51758
- Evaporation rateNo data available
- Flammability (solid, gas)does not ignite - Flammability (solids)
- Upper/lower flammability or explosive limits6.6%
- Vapour pressure 1,3 hPa at 50 °C
- Vapour density 3,9
- Relative density0.962
- Water solubility7,5 g/l at 20 °C
- Partition coefficient: n-octanol/waterlog Pow: 1,39 - (Lit.), Bioaccumulation is not expected.
- Autoignition temperature 480 °C - DIN 51794
- Decomposition temperature No data available
- ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
Other safety information
Solubility in other solvents
Ether at 20 °C
-
soluble Alcohol at 20 °C
-
soluble
Dissociation constant 5,08 at 25 °C
Relative vapor density
3,9
Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
Risk of explosion with:
Nitric acid
Risk of ignition or formation of inflammable gases or vapours with: mineral acids
acids
Conditions to avoid
Strong heating.
Incompatible materials
various plastics
Hazardous decomposition products
In the event of fire: see section 5
Information on toxicological effects
Acute toxicityAcute toxicity estimate Inhalation - 4 h - 3,1 mg/l (Expert judgment)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rabbit - 890 mg/kg Remarks: (RTECS)
Result: No skin irritation - 4 h (OECD Test Guideline 404)
(OECD Test Guideline 405)
(ECHA)
Metabolic activation: Metabolic activation Method: OECD Test Guideline 473 Result: positive
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium Metabolic activation: Metabolic activation
Method: OECD Test Guideline 471 Result: positive
Species: Mouse Application Route: Oral Remarks: DNA inhibition
Species: Mouse
Application Route: Intraperitoneal Remarks: DNA damage
Toxicity
LC50 - Pimephales promelas (fathead minnow) - 13,5 - 16,3 mg/l - 96,0 h
Toxicity to daphnia and other aquatic
semi-static test EC50 - Daphnia magna (Water flea) - 0,12 mg/l - 48 h
invertebrates (OECD Test Guideline 202)
(OECD Test Guideline 201)
Growth inhibition NOEC - Pseudokirchneriella subcapitata (green algae) - 3,1 mg/l - 72 h
(OECD Test Guideline 201)
Remarks: (Lit.)
Persistence and degradability
Biodegradability aerobic - Exposure time 20 d
Result: > 68 % - Readily biodegradable. (OECD Test Guideline 301D)
Biochemical Oxygen Demand (BOD)
1.630 mg/g
Bioaccumulative potential
Mobility in soil
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
Additional ecological information
No data available
Waste treatment methods
para-Toluidine is incompatible with oxidizers; contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.
Product
See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.
Waste DisposalConsult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration (oxides of nitrogen are removed from the effluent gas by scrubbers and/or thermal devices).
UN number
UN proper shipping name
Transport hazard class(es)
Packaging group
ADR/RID: II IMDG: II IATA: II
Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA: no
Special precautions for user
No data available
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
Other Information
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.