Thioglycolic acid
Product identifier
- Product name: Thioglycolic acid
- CBnumber: CB6477604
- CAS: 68-11-1
- EINECS Number: 200-677-4
- Synonyms: Thioglycolic acid,Mercaptoacetic acid
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: Thioglycolic acid
- Synonyms: Thioglycolic acid,Mercaptoacetic acid
- CAS: 68-11-1
- EC number: 200-677-4
- MF: C2H4O2S
- MW: 92.12
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides Sulfur oxides Combustible.
Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Further information
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb?). Dispose of properly. Clean up affected area.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.
Storage stability
Recommended storage temperature 2 - 8 °C
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Personal protective equipmentUse equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Full contact
Material: Chloroprene
Minimum layer thickness: 0,65 mm Break through time: 480 min Material tested:KCL 720 Camapren?
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Splash contact Material: Latex gloves
Minimum layer thickness: 0,6 mm Break through time: 120 min
Material tested:Lapren? (KCL 706 / Aldrich Z677558, Size M)
Acid-resistant protective clothing
Recommended Filter type: Respirator.
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Do not let product enter drains.
Information on basic physicochemical properties
- Appearancecolorless liquid
- OdourStench.
- Odour ThresholdNo data available
- pH1,5 at 10 g/l at 20 °C
- Melting point/freezing pointMelting point/range: -16 °C
- Initial boiling point and boiling range 96 °C at 7 hPa
- Flash point130 °C - closed cup
- Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limits Lower explosion limit: 5,9 %(V)
- Vapour pressure 0,5 hPa at 25 °C
- Vapour density 3,18 - (Air = 1.0)
- Relative densityNo data available
- Water solubility1.000 g/l at 20 °C - OECD Test Guideline 105- completely soluble
- Partition coefficient: n-octanol/waterlog Pow: -2,99 at 22 °C - Bioaccumulation is not expected.
- Autoignition temperature315 °C at 1.020 hPa - ASTM E-659
- Decomposition temperature No data available
- ViscosityViscosity, kinematic: 4,69 mm2/s at 20 °C - OECD Test Guideline 114 Viscosity, dynamic: 6,55 mPa.s at 20 °C
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
Other safety information
Relative vapor density
3,18 - (Air = 1.0)
Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
Violent reactions possible with:
Organic Substances Strong oxidizing agents strong alkalis
Conditions to avoid
Strong heating.
Incompatible materials
various metals
Hazardous decomposition products
In the event of fire: see section 5
Information on toxicological effects
Acute toxicityAcute toxicity estimate Inhalation - 4 h - 3,1 mg/l (Expert judgment)
Acute toxicity estimate Inhalation - Expert judgment - 4 h - 3,1 mg/l (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
LD50 Dermal - Rabbit - male and female - 848 mg/kg (OECD Test Guideline 402)
Result: Causes serious eye damage. (Regulation (EC) No. 440/2008, Annex, B.5) Causes serious eye damage.
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471
Result: negative
Test Type: In vitro mammalian cell gene mutation test Test system: mouse lymphoma cells
Metabolic activation: with and without metabolic activation Method: Regulation (EC) No. 440/2008, Annex, B.17
Result: negative
Test Type: Chromosome aberration test in vitro Test system: Human lymphocytes
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473
Result: negative
Test Type: Micronucleus test Species: Mouse
Cell type: Bone marrow Application Route: Dermal Method: OECD Test Guideline 474 Result: negative
Toxicity
(OECD Test Guideline 203)
static test EC50 - Daphnia magna (Water flea) - 38 mg/l - 48 h (OECD Test Guideline 202)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: Ammonium thioglycolate
Persistence and degradability
No data available
Bioaccumulative potential
No data available
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
No data available
Waste treatment methods
Compounds of the carboxyl group react with all bases. Incompatible with arsenic compounds, diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides , thiosulfates and dithionites.
Product
See www.retrologistik.com for processes regarding the return of chemicals and
containers, or contact us there if you have further questions.
Waste DisposalDissolve in flammable solvent and burn in furnace equipped with afterburner and alkaline scrubber.
UN number
ADR/RID: 1940 IMDG: 1940 IATA: 1940
UN proper shipping name
| | ADR/RID: THIOGLYCOLIC ACID IMDG: THIOGLYCOLIC ACID | |
| IATA: Thioglycolic acid | ||
| 14.3 | Transport hazard class(es) ADR/RID: 8 IMDG: 8 | IATA: 8 |
| 14.4 | Packaging group ADR/RID: II IMDG: II | IATA: II |
| 14.5 | Environmental hazards ADR/RID: no IMDG Marine pollutant: no | IATA: no |
| 14.6 | Special precautions for user No data available | |
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
Other Information
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.