Hexamethylene Diisocyanate
Product identifier
- Product name: Hexamethylene Diisocyanate
- CBnumber: CB4255051
- CAS: 822-06-0
- EINECS Number: 212-485-8
- Synonyms: HMDI,Hexamethylene diisocyanate
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: Hexamethylene Diisocyanate
- Synonyms: HMDI,Hexamethylene diisocyanate
- CAS: 822-06-0
- EC number: 212-485-8
- MF: C8H12N2O2
- MW: 168.19
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides Nitrogen oxides (NOx) Combustible.
Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Further information
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
| HEALTH | 4 | Very short exposure could cause death or major residual injury (e.g. hydrogen cyanide, phosgene, methyl isocyanate, hydrofluoric acid) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 1 | Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb?). Dispose of properly. Clean up affected area.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.
Store under inert gas. Moisture sensitive.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Personal protective equipmentUse equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0,7 mm Break through time: 480 min Material tested:Butoject? (KCL 898)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Splash contact Material: Nitrile rubber
Minimum layer thickness: 0,4 mm Break through time: 30 min
Material tested:Camatril? (KCL 730 / Aldrich Z677442, Size M)
protective clothing
Recommended Filter type: Filter B-(P2)
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Do not let product enter drains.
Information on basic physicochemical properties
- Appearanceclear, colorless clear, liquid
- Odourpungent
- Odour ThresholdNo data available
- pHNo data available
- Melting point/freezing pointMelting point/freezing point: ca.-67 °C - (ECHA)
- Initial boiling point and boiling range82 - 85 °C at 0,1 hPa
- Flash point130 °C - Pensky-Martens closed cup - DIN 51758
- Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limits Upper explosion limit: 9,5 %(V) Lower explosion limit: 0,9 %(V)
- Vapour pressure 0,007 hPa at 20 °C
- Vapour density No data available
- Relative density1.05
- Water solubilityHydrolysis
- Partition coefficient: n-octanol/waterlog Pow: 3,2 at 25 °C - Bioaccumulation is not expected.
- Autoignition temperature 454 °C at 1.013,25 hPa
- Decomposition temperature No data available
- ViscosityViscosity, kinematic: 1,68 mm2/s at 40 °C - OECD Test Guideline 1142,29 mm2/s at 20 °C - OECD Test Guideline 114 Viscosity, dynamic: 1,73 mPa.s at 40 °C - OECD Test Guideline 1142,4 mPa.s at 20 °C - OECD Test Guideline 114
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
Other safety information
No data available
Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
Release of:
Carbon dioxide (CO2) Risk of explosion with:
Alcohols with Bases
Exothermic reaction with:
Alcohols amides Amines
Oxidizing agents
Strong acids and strong bases mercaptans
phenols
Conditions to avoid
Incompatible materials
nonferrous metals, Copper, Copper alloys, Mild steel, Zinc
Hazardous decomposition products
In the event of fire: see section 5
Information on toxicological effects
Acute toxicityLC50 Inhalation - Rat - male and female - 4 h - 0,124 mg/l (OECD Test Guideline 403)
LD50 Dermal - Rat - male and female - > 7.000 mg/kg (OECD Test Guideline 402)
Result: Corrosive after 1 to 4 hours of exposure - 4 h (OECD Test Guideline 404)
Result: Causes serious eye damage. (OECD Test Guideline 405)
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation Result: negative
Remarks: (ECHA)
Test Type: In vitro mammalian cell gene mutation test Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Result: negative
Remarks: (ECHA)
Test Type: Micronucleus test Species: Mouse
Cell type: Bone marrow
Application Route: inhalation (vapor) Method: OECD Test Guideline 474 Result: negative
Toxicity
No data available
(OECD Test Guideline 201)
Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 42 % - Not readily biodegradable. (OECD Test Guideline 301F)
Bioaccumulative potential
No data available
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
Stability in water - 5 - 10 min at 20 °C
Remarks: Hydrolyzes on contact with water.
Waste treatment methods
Incompatible with oxi dizers; contact may cause fires or explosions. Incompatible with amines, aldehydes, alkali metals, ammonia, carboxylic acids, capro lactum, alkaline materials, glycols, ketones, mercaptans, hydrides, organotin catalysts, phenols, strong acids, strong bases, strong reducing agents such as hydrides, urethanes, ureas.
Product
See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.
Waste DisposalDisposal is by chemical incineration of HDIsolution in a combustible solvent.
UN number
ADR/RID: 2281 IMDG: 2281 IATA: 2281
| 14.2 | UN proper shipping name ADR/RID: HEXAMETHYLENE DIISOCYANATE IMDG: HEXAMETHYLENE DIISOCYANATE IATA: Hexamethylene diisocyanate | |
| 14.3 | Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 | IATA: 6.1 |
| 14.4 | Packaging group ADR/RID: II IMDG: II | IATA: II |
| 14.5 | Environmental hazards ADR/RID: no IMDG Marine pollutant: no | IATA: no |
| 14.6 | Special precautions for user No data available | |
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
Other Information
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.