DL-Malic acid
Product identifier
- Product name: DL-Malic acid
- CBnumber: CB4220794
- CAS: 617-48-1
- EINECS Number: 210-514-9
- Synonyms: DL-Malic Acid,DL-Malate
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Eye irritation, Category 2
Label elements
Pictogram(s)
-
Signal word
Warning
H319 Causes serious eye irritation
P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
none
none
Other hazards
no data available
Substance
- Product name: DL-Malic acid
- Synonyms: DL-Malic Acid,DL-Malate
- CAS: 617-48-1
- EC number: 210-514-9
- MF: C4H6O5
- MW: 134.09
Description of first aid measures
If inhaledMove the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms and effects, both acute and delayed
no data available
Indication of any immediate medical attention and special treatment needed
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Organic acids and related compounds
Extinguishing media
Wear self-contained breathing apparatus for firefighting if necessary.
Specific Hazards Arising from the Chemical
no data available
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids.
Control parameters
Occupational Exposure limit valuesno data available
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
Information on basic physicochemical properties
- Physical stateSolid
- ColourWhite to Off-White
- Odour
Characteristic
- Melting point/freezing point
131 - 132 °C.
- Boiling point or initial boiling point and boiling range
150 °C. Atm. press.:Ca. 1 atm.
- Flammability
no data available
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
203°C
- Auto-ignition temperature
> 150 °C. Remarks:No evidence of self heating up to boiling point temperature.
- Decomposition temperature
no data available
- pH
pH of a 0.001% aqueous solution is 3.80, that of 0.1% solution is 2.80, and that of a 1.0% solution is 2.34
- Kinematic viscosity
6.5 mPa.s (= cP) 50% aqueous solution at 25 deg C
- Solubilitymethanol: 0.1 g/mL, clear, colorless
- Partition coefficient n-octanol/water
log Pow = -1.27. Temperature:24 °C. Remarks:PH buffer used.
- Vapour pressure<0.1 mm Hg ( 20 °C)
- Density and/or relative density
1.601 g/cm3. Temperature:25 °C.
- Relative vapour density
no data available
- Particle characteristics
no data available
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Bases, oxidizing agents, reducing agents, alkali metals.
Hazardous decomposition products
When heated to decomposition it emits acrid smoke and irritating fumes.
Acute toxicity
- Oral: LD50 - rat (male) - 10 700 mg/kg bw.
- Inhalation: LC50 - rat (male/female) - > 1.306 mg/L air (analytical).
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
Toxicity
- Toxicity to fish: LC50 - Danio rerio (previous name: Brachydanio rerio) - > 100 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: Daphnia magna.
- Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - > 100 mg/L - 72 h.
- Toxicity to microorganisms: EC50 - activated sludge of a predominantly domestic sewage - > 300 mg/L - 3 h. Remarks:Respiration rate.
Persistence and degradability
AEROBIC: In an aerobic closed bottle screening study using activated sludge and soil inoculum, malic acid had 5-, 15- and 30-day theoretical BODs of 68, 81 and 100% respectively(1). In a Warburg respirometer study using an activated sludge inoculum, theoretical BODs of 6.0-9.6% and 20.8-55.5% were observed over respective incubation periods of 4 and 24 hrs(2). In a Warburg respirometer study using a sewage sludge inoculum, a theoretical BOD of 47.2% was observed over an incubation period of 5 days(3). A theoretical BOD of 56.3% was observed in a standard BOD dilution test using a sewage inoculum(4). In a Warburg respirometer study using a phenol acclimated activated sludge inoculum, a theoretical BOD of 46% was observed over an incubation period of 12 hrs(5). Using C14-radio-labeled malic acid and a 1-hr incubation period, a 6.7% CO2 evolution was observed in a natural soil degradation study(6); when the soil was sterilized via autoclaving, the CO2 evolution was only 0.1%(6). DL-Malic acid, present at 100 mg/L, reached 73% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test which classified the compound as readily biodegradable(7).
Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for malic acid(SRC), using a log Kow of -1.26(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of malic acid can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that malic acid is expected to have very high mobility in soil. The pKa values of malic acid are 3.51 and 5.03(3), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Packing group, if applicable
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.