Dimethyl dicarbonate
Product identifier
- Product name: Dimethyl dicarbonate
- CBnumber: CB9496174
- CAS: 4525-33-1
- EINECS Number: 224-859-8
- Synonyms: dimethyl dicarbonate,Velcorin
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Acute toxicity - Category 4, Dermal
Skin corrosion, Sub-category 1B
Acute toxicity - Category 2, Inhalation
Label elements
Pictogram(s)
- Signal wordDanger
H314 Causes severe skin burns and eye damage
H330 Fatal if inhaled
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P284 [In case of inadequate ventilation] wear respiratory protection.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P317 Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316 Get emergency medical help immediately.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P320 Specific treatment is urgent (see ... on this label).
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: Dimethyl dicarbonate
- Synonyms: dimethyl dicarbonate,Velcorin
- CAS: 4525-33-1
- EC number: 224-859-8
- MF: C4H6O5
- MW: 134.09
Description of first aid measures
If inhaledMove the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms and effects, both acute and delayed
no data available
Indication of any immediate medical attention and special treatment needed
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Esters and related compounds
Extinguishing media
Suitable Extinguishing Media: All extinguishing media are suitable. Special Fire Fighting Procedures: Firefighters should be equipped with self-contained breathing apparatus to protect against potentially toxic and irritating fumes. Use cold water spray to cool fire-exposed containers to minimize risk of rupture.
Specific Hazards Arising from the Chemical
no data available
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Spill and Leak Procedures: Cleanup personnel must use appropriate personal protective equipment. Do not allow spilled material or wash water to enter sewers, surface waters, or groundwater systems. Remove all sources of ignition, including flames, heat, and sparks. Ventilate area to remove vapors or dust. Evacuate and keep unnecessary people out of spill area. Cover spill with damp, fluid-binding material (for example, sand, sawdust, chemical binder based on calcium silicate hydrate). Transfer to an open waste container after approximately one hour, cover loosely and remove to an isolated area. Do not seal the container as carbon dioxide given off by the slow reaction between Velcorin and water may cause a tightly sealed container to burst. Flush the spill with cold water but avoid flushing into open drains. Hot water should never be used for this purpose since it would cause considerable vaporization of the spilled material. Use the paper Velcorin indicator strips to insure that there is no residual Dimethyl Dicarbonate in the air.
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Storage Temperature: minimum: 20 deg C (68 deg F); maximum: 30 deg C (86 deg F). Storage Period: 12 Months: Keep in a dry place. Expiration date on label is day/month/year. Handling/Storage Precautions: Do not breathe vapors or spray mist. Do not get on skin or clothing. Do not get in eyes. Do not taste or swallow. Use only with adequate ventilation/personal protection. Wash thoroughly after handling. Keep container closed when not in use. Store in a dry place away from excessive heat in original or similar containers. Protect from freezing. Further Info on Storage Conditions: Avoid extreme heat. Product can react with water. Avoid contact with moisture/water. Light sensitive. If the material does crystallize, it must be reliquified before being used. The recommended method to reliquify is to simply place the container in an appropriate storage area and allow it to gradually reach ambient temperatures. An alternative is to reliquify by gently heating it in a water bath. Do NOT apply heat/flame directly to container.
Control parameters
Occupational Exposure limit valuesno data available
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
Information on basic physicochemical properties
- Physical state
Colourless liquid, decomposes in aqueous solution. It is corrosive to skin and eyes and toxic by inhalation and ingestion
- Colour
Clear, colorless liquid
- Odour
no data available
- Melting point/freezing point
15-17°C
- Boiling point or initial boiling point and boiling range
45-46°C/5mmHg(lit.)
- Flammability
no data available
- Lower and upper explosion limit/flammability limit3-29.9%(V)
- Flash point
80°C
- Auto-ignition temperature
Approximately 465 deg C (869 deg F)
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
no data available
- Solubility35g/l (decomposition)
- Partition coefficient n-octanol/water
log Kow = -0.86 (est)
- Vapour pressure0.7 hPa (20 °C)
- Density and/or relative density
1.25g/mLat 25°C(lit.)
- Relative vapour density
no data available
- Particle characteristics
no data available
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
Combustible
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
Hazardous decomposition products: By Fire and Thermal Decomposition: Methanol; Carbon oxides, nitrogen oxides (NOx), other potentially toxic fumes.
Acute toxicity
- Oral: LD50 Mouse (female) oral 752.7 mg/kg
- Inhalation: LC50 Mouse (female) inhalation >1477 mg/cu m/ 4 hours
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: While biodegradation data for dimethyl dicabonate were not available(SRC, 2013), dimethyl carbonate, a structural analog, was >90% biodegraded in 28 days using an activated sludge inoculum in the OECD 301C test (Modified MITI)(1).
Bioaccumulative potential
An estimated BCF of 3.2 was calculated in fish for dimethyl dicarbonate(SRC), using an estimated log Kow of -0.86(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of dimethyl dicarbonate can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that dimethyl dicarbonate is expected to have very high mobility in soil.
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN2927 (For reference only, please check.)
IMDG: UN2927 (For reference only, please check.)
IATA: UN2927 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: TOXIC LIQUID, CORROSIVE, ORGANIC, N.O.S. (For reference only, please check.)
IMDG: TOXIC LIQUID, CORROSIVE, ORGANIC, N.O.S. (For reference only, please check.)
IATA: TOXIC LIQUID, CORROSIVE, ORGANIC, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.