4-Nitrobiphenyl
Product identifier
- Product name: 4-Nitrobiphenyl
- CBnumber: CB7482649
- CAS: 92-93-3
- EINECS Number: 202-204-7
- Synonyms: 4-Nitrobiphenyl,4-nitro-1,1'-biphenyl
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Carcinogenicity, Category 1B
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
Label elements
Pictogram(s)
-
Signal word
Danger
H350 May cause cancer
H411 Toxic to aquatic life with long lasting effects
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
P318 IF exposed or concerned, get medical advice.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: 4-Nitrobiphenyl
- Synonyms: 4-Nitrobiphenyl,4-nitro-1,1'-biphenyl
- CAS: 92-93-3
- EC number: 202-204-7
- MF: C12H9NO2
- MW: 199.21
Description of first aid measures
If inhaledFresh air, rest. Refer for medical attention.
Remove contaminated clothes. Rinse and then wash skin with water and soap.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Refer for medical attention .
Most important symptoms and effects, both acute and delayed
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Headache, drowsiness, dizziness; dyspnea (breathing difficulty); ataxia, lassitude (weakness, exhaustion); methemoglobinemia; urinary burning; acute hemorrhagic cystitis; [potential occupational carcinogen] Target Organs: Bladder, blood (NIOSH, 2016)
Indication of any immediate medical attention and special treatment needed
Absorption, Distribution and Excretion4-nitrodiphenyl ... known to readily penetrate intact skin.
Extinguishing media
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)
Specific Hazards Arising from the Chemical
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. (ERG, 2016)
Advice for firefighters
Use water spray.
NFPA 704
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Research program was conducted to determine the capability of biol treatment and activated carbon adsorption to remove chem carcinogens from water and wastewater. cmpd studied incl 4-nitrobiphenyl. all cmpd tested exhibited some deg of biol degradation. carbon adsorption was also effective in removing the cmpd from aq soln.
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong reducing agents. Well closed.
Control parameters
Occupational Exposure limit valuesTLV: (skin); A2 (suspected human carcinogen).MAK: skin absorption (H); carcinogen category: 2
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear safety spectacles or eye protection in combination with breathing protection if powder.
Protective gloves. Protective clothing.
Use local exhaust or breathing protection.
no data available
Information on basic physicochemical properties
- Physical stateSolid
- ColourWhite
- Odour
SWEETISH ODOR
- Melting point/freezing point
114°C
- Boiling point or initial boiling point and boiling range
340°C
- Flammability
Combustible Solid
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
43°C
- Auto-ignition temperature
no data available
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
no data available
- SolubilitySoluble in acetic acid, benzene, chloroform, and ether (Weast, 1986)
- Partition coefficient n-octanol/water
log Kow= 3.77 (est)
- Vapour pressure
no data available
- Density and/or relative density
1.328
- Relative vapour density
no data available
- Particle characteristics
no data available
Reactivity
NIOSH has recommended that 4-nitrobiphenyl be treated as a potential human carcinogen.
Decomposes on burning. This produces toxic gases. Reacts with strong reducing agents. This generates toxic hazard.
Chemical stability
no data available
Possibility of hazardous reactions
4-NITROBIPHENYL is incompatible with the following: Strong reducers (NIOSH, 2016).
Conditions to avoid
no data available
Incompatible materials
Strong reducers.
Hazardous decomposition products
When heated to decomp it emits toxic fumes of /nitrogen oxides/.
Acute toxicity
- Oral: LD50 Rabbit oral 1.97 g/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
Reproductive toxicity
No information is available on the reproductive or developmental effects of 4-nitrobiphenyl in humans or animals.
STOT-single exposure
The substance is irritating to the eyes.
STOT-repeated exposure
This substance is probably carcinogenic to humans.
Aspiration hazard
A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
p-Nitrobiphenyl exhibited fast biodegradation with rapid adaptation using a static-culture screening procedure with a settled domestic wastewater microbial inocula(1); degradation was determined to be 97.5% after 7 days of incubation(1).
Bioaccumulative potential
Based upon an estimated log Kow of 3.77(1), the BCF for p-nitrobiphenyl can be estimated to be 432 from a recommended regression equation(2,SRC). This estimated BCF value suggests that moderate bioconcentration may occur(SRC).
Mobility in soil
Based upon an estimated log Kow of 3.77(1), the Koc for p-nitrobiphenyl can be estimated to range from 2680 to 3360 using various regression-derived equations(2,SRC). These Koc estimates indicate very low soil mobility(3).
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN3077 (For reference only, please check.)
IMDG: UN3077 (For reference only, please check.)
IATA: UN3077 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 9 (For reference only, please check.)
IMDG: 9 (For reference only, please check.)
IATA: 9 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Similar substances have caused methemoglobinemia, but there are no data available for this substance.Depending on the degree of exposure, periodic medical examination is suggested.Do NOT take working clothes home.TLV Note: Exposure by all routes should be carefully controlled to levels as low as possible.
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.