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Journal of Herbal Medicine

Journal of Herbal Medicine

IF: 2.2
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Anticancer Properties of Some Selected Plant Phenolic Compounds: Future Leads for Therapeutic Development

Published:17 October 2023 DOI: 10.1016/j.hermed.2023.100801
N. Maheshwari , M.C. Sharma

Abstract

Introduction

A shift in interest in searching for newer anticancer molecules from synthetic to herbal sources has been clearly observed over the past few decades. Among herbal compounds, phenolic-rich extracts are studied extensively. This review examined the recent findings on the anticancer properties and therapeutic efficacy of different phenolic extracts (quercetin, carvacrol, curcumin, hydroxychavicol, crocin, palmatine, aloin, gingerol, allicin, epigallocatechin, thymol, pyrogallol, and carvone) obtained from different geographical locations.

Methods

The present study utilises international scientific databases including Scopus, Elsevier, Pubmed (NCBI database), leading natural product/phytochemical journals (articles; research, reviews, quick notes, mini reviews, editorials, etc.), relevant books, periodicals, student dissertations, and government resources. More?than 200 key articles were downloaded and reviewed. Medicinal Plant Names Services and Materia Medica validated plant taxonomy was used at relevant places. The investigations carried out between 2005 and 2022 were included.

Results

During the search, the majority of these phenolic extracts investigated were found to modulate one or more signalling pathways linked with cell survival, cell propagation/differentiation, cell migration, angiogenesis, cell cycle, apoptosis, detoxification enzymes, hormone activities, reactive oxygen species?up-and-downregulation, altered gene expression, and immune responses. Besides, they are also found to effectively scavenge the multitude of non-biological superoxide radical, free radical, nitrogen and chlorine species, hydrogen peroxide, and various reactive oxygen species. Interestingly, several phenolics studied to date possess different pharmacology and pathways to treat different cancers.

Conclusions

Various cellular and molecular pathways presented for these translatable (lab to clinic) phenolics as possible cancer treatment leads in the future.

Substances (13)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Curcumin 458-37-7 C21H20O6 1039 suppliers $5.00-$1280.00
Thymol 89-83-8 C10H14O 819 suppliers $5.00-$1960.00
Pyrogallol 87-66-1 C6H6O3 756 suppliers $6.00-$1211.00
Quercetin 117-39-5 C15H10O7 613 suppliers $5.00-$925.00
Carvacrol 499-75-2 C10H14O 546 suppliers $5.00-$4562.37
6-Gingerol 23513-14-6 C17H26O4 420 suppliers $18.00-$1963.50
(-)-Epigallocatechin 970-74-1 C15H14O7 404 suppliers $5.00-$1790.00
Allicin 539-86-6 C6H10OS2 367 suppliers $50.00-$2040.00
Palmatine 3486-67-7 C21H22NO4+ 336 suppliers Inquiry
Crocin 42553-65-1 C44H64O24 326 suppliers $16.80-$3980.00

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