成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook >> journal list >> Pharmacology & Therapeutics >>article
Pharmacology & Therapeutics

Pharmacology & Therapeutics

IF: 12
Download PDF

Natural and synthetic inhibitors of UDP-glucuronosyltransferase

Published:1 February 2001 DOI: 10.1016/S0163-7258(00)00109-1
Konstantin Grancharov, Zlatina Naydenova, Svetla Lozeva, Evgeny Golovinsky

Abstract

Glucuronidation is a major detoxification pathway in vertebrates. The reaction is catalyzed by a family of UDP-glucuronosyltransferases (UGTs) and involves conjugation of many endobiotic and xenobiotic substances with glucuronic acid, forming inactive water-soluble glucuronides. UGT prevents the accumulation of potentially toxic compounds and/or their subsequent bioactivation to more toxic intermediates, although biologically active glucuronides are also known. Impairment of UGTs may have important toxicological consequences. Substances found to inhibit or down-regulate UGT activity include endogenous compounds, a wide range of clinically used drugs, environmental contaminants, and natural toxic substances present in the diet. The development of selective, active-site-directed UGT inhibitors greatly enables the study of various UGT isoenzymes. A promising approach offers the design of transition-state analogs of the glucuronidation reaction.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
D-Glucuronic acid 6556-12-3 C6H10O7 316 suppliers $22.40-$980.00
Canagliflozin-2-Glucuronide C30H33FO11S 9 suppliers Inquiry
UDP-glucuronosyltransferase 1-1 ELISA Kit 1 suppliers Inquiry

Similar articles

IF:3.6

Virtual Screening and Biological Evaluation of Natural Products as Novel VPS34 Inhibitors that Modulate Autophagy

ChemMedChem Xiaowen Feng, Baoming Wu,etc Published: 22 November 2024
IF:3.7

Efficient production of chemicals from microorganism by metabolic engineering and synthetic biology

Chinese Journal of Chemical Engineering Yang Zhang, Jing Yu,etc Published: 1 February 2021
IF:0

Synthetic anabolic agents: steroids and nonsteroidal selective androgen receptor modulators.

Handbook of experimental pharmacology Mario Thevis, Wilhelm Sch?nzer,etc Published: 1 January 2010