Cover Feature: Sequential Nucleophilic Substitution of Phosphorus Trichloride with Alcohols in a Continuous-Flow Reactor and Consideration of a Mechanism for Reduced Over-reaction through the Addition of Imidazole (Chem. Eur. J. 37/2022)
Published:13 June 2022
DOI: 10.1002/chem.202201646
Hiroshi Kitamura, Yuma Otake, Naoto Sugisawa, Dr. Hiroki Sugisawa, Prof.?Dr. Tomonori Ida, Prof.?Dr. Hiroyuki Nakamura, Prof.?Dr. Shinichiro Fuse
Abstract
Sequential nucleophilic substitution of phosphorus trichloride with alcohols has been achieved. Over-reaction was suppressed by rapid mixing through micro-flow technology, and asymmetric phosphotriesters containing acid- and/or base-labile functional groups were synthesized in good to high yields. Moreover, a mechanistic study by using DFT calculations suggested interesting reaction pathways. More information can be found in the Research Article by S. Fuse and co-workers (DOI: 10.1002/chem.202200932).