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Journal of Ginseng Research

Journal of Ginseng Research

IF: 6.79
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The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in?vitro and in?vivo.

Published:1 March 2023 DOI: 10.1016/j.jgr.2022.09.011
Qi-rui Hu , Yao Pan , Han-cheng Wu , Zhen-zhen Dai , Qing-xin Huang , Ting Luo , Jing Li , Ze-yuan Deng , Fang Chen

Abstract

Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternatives for therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2 (GRh2) is the main phytochemical extracted from Panax ginseng C.A. Meyer with anticancer activity. GRh2 could induce apoptosis and autophagy of cancer cells and inhibit proliferation, metastasis, invasion, and angiogenesis in?vitro and in?vivo. In addition, GRh2 could be used as an adjuvant to chemotherapeutics to enhance the anticancer effect and reverse the adverse effects. Here we summarized the understanding of the molecular mechanisms underlying the anticancer effects of GRh2 and proposed future directions to promote the development and application of GRh2.

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Procduct Name CAS Molecular Formula Supplier Price
Ginsenoside Rh2 78214-33-2 C36H62O8 273 suppliers $39.00-$5330.00
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