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Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugates

Published:20 October 2023 DOI: 10.1016/j.isci.2023.107778 PMID: 37727735
Zhiwen Fu , Chen Gao , Tingting Wu , Lulu Wang , Shijun Li , Yu Zhang , Chen Shi

Abstract

Since the successful approval of gemtuzumab ozogamicin, antibody-drug conjugates (ADCs) have emerged as a pivotal category of targeted therapies for cancer. Among these ADCs, the use of monomethyl auristatin E (MMAE) as a payload is prevalent in the development of ADC drugs, which has significantly improved overall therapeutic efficacy against various malignancies. However, increasing clinical observations have raised concerns regarding the potential nervous system toxicity associated with MMAE-based ADCs. Specifically, a higher incidence of peripheral neuropathy has been reported in ADCs incorporating MMAE as payloads. Considering the increasing global use of MMAE-based ADCs, it is imperative to provide an inclusive overview of diagnostic and management strategies for this adverse event. In this review, we examine current information and what future research directions are required to better understand and manage this type of clinical challenge.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
MonoMethyl auristatin E 474645-27-7 C39H67N5O7 292 suppliers $49.00-$3260.00
Auristatin E 160800-57-7 C40H69N5O7 78 suppliers Inquiry

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