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Neural Regeneration Research

Neural Regeneration Research

IF: 5.9
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Pentadecapeptide BPC 157 and the central nervous system.

Published:1 March 2022 DOI: 10.4103/1673-5374.320969 PMID: 34380875
Jak?a Vukojevic, Marija Milavi?, Darko Perovi?, Spomenko Ili?, Andrea Zemba ?ili?, Nata?a ?uran, Sanja ?trbe, Zoran Zori?i?, Igor Filip?i?, Petrana Bre?i?, Sven Seiverth, Predrag Sikiri?

Abstract

We reviewed the pleiotropic beneficial effects of the stable gastric pentadecapeptide BPC 157, three very recent demonstrations that may be essential in the gut-brain and brain-gut axis operation, and therapy application in the central nervous system disorders, in particular. Firstly, given in the reperfusion, BPC 157 counteracted bilateral clamping of the common carotid arteries-induced stroke, sustained brain neuronal damages were resolved in rats as well as disturbed memory, locomotion, and coordination. This therapy effect supports particular gene expression in hippocampal tissues that appeared in BPC 157-treated rats. Secondly, there are L-NG-nitro arginine methyl ester (L-NAME)- and haloperidol-induced catalepsy as well as the rat acute and chronic models of 'positive-like' schizophrenia symptoms, that BPC 157 counteracted, and resolved the complex relationship of the nitric oxide-system with amphetamine and apomorphine (dopamine agents application), MK-801 (non-competitive antagonist of the N-methyl-D-aspartate receptor) and chronic methamphetamine administration (to induce sensitivity). Thirdly, after rat spinal cord compression, there were advanced healing and functional recovery (counteracted tail paralysis). Likewise, in BPC 157 therapy, there is specific support for each of these topics: counteracted encephalopathies; alleviated vascular occlusion disturbances (stroke); counteracted dopamine disturbances (dopamine receptors blockade, receptors super sensitivity development, or receptor activation, over-release, nigrostriatal damage, vesicles depletion), and nitric oxide-system disturbances ("L-NAME non-responsive, L-arginine responsive," and "L-NAME responsive, L-arginine responsive") (schizophrenia therapy); inflammation reduction, nerve recovery in addition to alleviated hemostasis and vessels function after compression (spinal cord injury therapy). Thus, these disturbances may be all resolved within the same agent's beneficial activity, i.e., the stable gastric pentadecapeptide BPC 157.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
L(+)-Arginine 74-79-3 C6H14N4O2 1240 suppliers $5.00-$6815.00
Haloperidol 52-86-8 C21H23ClFNO2 412 suppliers $30.00-$1504.50
BPC 157 137525-51-0 C62H98N16O22 226 suppliers Inquiry
N-OMEGA-PROPYL-L-ARGININE 137361-05-8 C9H20N4O2 68 suppliers $41.40-$1871.10
L-NAME C7H15N5O4 4 suppliers Inquiry
MK-801, (+)-[3H] - Inquiry

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