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ChemicalBook >> journal list >> Cardiovascular and Hematological Agents in Medicinal Chemistry >>article

Andrographolide reorganise hyperglycaemia and distorted antioxidant profile in streptozotocin-induced diabetic rats.

Published:26 October 2017 DOI: 10.2174/1871525715666171026115248 PMID: 29076435
Ramavat Ravindhar Naik,?Praveen Kumar Munipally,?Turlapati Nagaraju

Abstract

Diabetes mellitus (DM) is a constant and illimitable metabolic disorder that can happen even at a young age due to the virtual absence of naturally acting insulin, which uptakes and accumulates glucose; thereby reduce the use of glucose. In the present study, we evaluated the neuroprotective efficacy of andrographolide on streptozotocin (STZ) induced diabetic Sprague dawley rats. Diabetes was induced by intraperitonial injection of STZ (45 mg/kg B.W) in Sprague dawley rats. Andrographolide (2.5 mg/kg B.W) was administered orally to diabetic rats and Glibenclamide (25mg/kg B.W) as control for 30 days to assess its effects on blood glucose, insulin, insulin resistance and antioxidant profiles such as superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and lipid peroxidation in various regions of brain namely hypothalamus, cerebellum, hippocampus and brain cerebral cortex. Oral supplementation of andrographolide extensively diminished the blood glucose levels than diabetic control. There was noteworthy reduction in the CAT, SOD and GPx activities in the hippocampus, hypothalamus and cerebral cortex cerebellum of the DM rat brain. However, andrographolide supplementation drastically reverses the CAT, GPx and SOD back to normal levels. In conclusion, the results revealed that andrographolide shown beneficial potentiality against neuropathy in STZ induced diabetic rats.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Glibenclamide 10238-21-8 C23H28ClN3O5S 683 suppliers $6.00-$625.00
Andrographolide 5508-58-7 C20H30O5 650 suppliers $10.00-$640.00
Streptozotocin 18883-66-4 C8H15N3O7 434 suppliers $25.00-$1610.00

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